Stevia residue extract ameliorates oxidative stress in d-galactose-induced aging mice via Akt/Nrf2/HO-1 pathway

Zhao, Lei; Yang, Haoxiong; Xu, Meili; Wang, Xin; Mehmood, Arshad; Lian, Yunhe; Mehmood, Arshad; Dai, Haochen

doi:10.1016/j.jff.2018.11.044

Cited by 42 publications

(39 citation statements)

References 41 publications

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“…Many researchers have studied the role of oxidative stress in D-galactose-induced animal models [23][24][25][26][27][28][29]. In our study, we proved that supplementation with dried bovine placenta can improve spermatozoa count in rats induced into aging by D-galactose.…”

Section: Discussionsupporting

confidence: 62%

Dried bovine placenta improves spermatozoa count in a rat model of male reproductive aging

et al. 2021

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Background and Aim: In the male reproductive system, the aging process can lead to infertility. Recently, placenta and its derivatives have been researched as regenerative agents. This study aimed to describe the basic components of dried bovine placenta powder and its potential effects as a regenerative agent in a rat model of male reproductive aging with D-galactose induction. Materials and Methods: We divided 15 male Wistar rats, 2 months of age, into three groups: A, the health control group; B, the D-galactose induction group, and C, the D-galactose induction and 10% dried bovine placenta supplementation group. We measured epididymal sperm concentration and testicular weight and volume and analyzed these using one-way analysis of variance. Results: Dried bovine placenta was rich in nutrients, with 61.98% protein, 21.25±2.07 carbohydrates, 8.58% water, 4.93% ash, and 3.27% fat. The mean epididymal spermatozoa concentration of the rats in Groups A, B, and C was 3026×106/mL, 1492.8×106/mL, and 2732.5×106/mL, respectively. The average total testicle weights were 2.44 g, 2.72 g, and 2.57 g, respectively. The average total testicle volumes were 2.29 cm3, 2.49 cm3, and 2.33cm3, respectively. Conclusion: Dried bovine placenta powder is rich in nutrients, especially protein. Supplementation with dried bovine placenta can improve epididymal spermatozoa concentration that is important in fertility.

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Section: Discussionsupporting

confidence: 62%

Dried bovine placenta improves spermatozoa count in a rat model of male reproductive aging

et al. 2021

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“…These antioxidant protein can regulate the redox balance in the body after being activated, and restore the body from oxidative stress back to normal physiological state (Xiong et al., 2020). Downstream antioxidant enzymes regulated by Nrf2 mainly include HO‐1, CAT, GPx, and SOD (Mahmoud et al., 2018; Zhao, Yang, et al., 2019). AYI treatments upregulated the activities, mRNA, and protein expressions of these enzymes.…”

Section: Resultsmentioning

confidence: 99%

Assessment of in vivo antioxidant activity of a tripeptide Ala‐Tyr‐Ile fromJiuzao(a by‐product of baijiu distillation) protein hydrolysates and its stability in baijiu

Jiang

Sun

Zhao

et al. 2020

J. Food Process. Preserv.

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Peptide Ala‐Tyr‐Ile (AYI) was isolated from Jiuzao protein hydrolysates and proved with antioxidant ability in vitro in the previous study. Considering the limitation in vitro, the antioxidant activity and potential mechanism in vivo of AYI were investigated by AAPH‐induced oxidative stress Sprague–Dawley (SD) rat model in this study. The results showed that AYI could activate Nrf2/Keap1‐p38/PI3K‐MafK signaling pathway both on gene and protein expressions. Meanwhile, AYI could markedly (p < .05) increase downstream antioxidant enzymes (i.e., CAT, GPx, SOD, and HO‐1) expressions and suppress the expressions of inflammatory factors (i.e., TNF‐α, IL‐1β, IL‐6, and NO). The results above indicated potential antioxidant and anti‐inflammatory activity in vivo of peptide AYI. In addition, AYI could also exist stably in baijiu after 14‐day storage. This study provides a better thought for the use of Jiuzao to isolate antioxidant peptides and enhance baijiu antioxidant function by adding these peptides in it. Practical applications Jiuzao is a by‐product of baijiu distillation, which is generally used as the forage of livestock. However, considering the raw material of baijiu distillation, nonvolatile components remain in Jiuzao, such as protein and peptides. Therefore, functional peptides can be extracted from Jiuzao. Peptide AYI was identified from Jiuzao protein hydrolysates and was proved with antioxidant ability in vitro. This study further explored its antioxidant capacity in vivo and proved it could be used as a natural ingredient for baijiu to enhance its antioxidant function. It can also contribute to pharmaceutical, cosmetic, and functional foods industry. In addition, other functional components in Jiuzao also deserve for exploring.

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“…In addition, recent research has identified Nrf2 and its downstream targets, HO-1 and NQO1, as key factors for combating hepatic oxidative stress by vegetables and the bioactive component [38,39], which were also shown to be upregulated by PG in this study. Increasing evidence indicates that PI3K/Akt are involved in the control of oxidative stress through the regulation of HO-1 and NQO1: previous research reported that stevia residue extract could increase antioxidative enzymes expression through the activation of the Akt/Nrf2/HO-1 pathway [40] in mice; bromocriptine was also reported to regulate Nrf2 activity and its downstream enzyme, NQO1, through the PI3K/Akt pathway [41] against oxidative stress. These findings confirmed oxidative stress as the second 'hit', following insulin resistance, which exacerbates NAFLD development.…”

Section: Discussionmentioning

confidence: 99%

Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease

Wang

Zhou

et al. 2020

Nutrients

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The root of Platycodon grandiflorus (PG), with hepatoprotective and anti-oxidation effects, has a long history of being used as food and herbal medicine in Asia. However, the mechanism of PG against non-alcoholic fatty liver disease (NAFLD) is still not clear. The aim of this study was to investigate the mechanism of PG suppressing the development of NAFLD induced by a high-fat diet (HFD) in mice. Male C57BL/6J mice were fed with either a standard chow diet or a HFD, either supplemented with or without PG, for 16 weeks. Serum lipids, liver steatosis, oxidative stress and insulin sensitivity were determined. Expressions or activities of hepatic enzymes in the related pathways were analyzed to investigate the mechanisms. PG significantly reduced HFD-induced hepatic injury and hyperlipidemia, as well as hepatic steatosis via regulating phosphorylation of acetyl-CoA carboxylase (p-ACC) and expression of fatty acid synthase (FAS). In addition, PG ameliorated oxidative stress by restoring glutathione (GSH) content and antioxidant activities, and improved insulin sensitivity by regulating the PI3K/Akt/GSK3β signaling pathway. Our data showed that dietary PG have profound effects on hepatic insulin sensitivity and oxidative stress, two key factors in the pathogenesis of NAFLD, demonstrating the potential of PG as a therapeutic strategy for NAFLD.

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Stevia residue extract ameliorates oxidative stress in d-galactose-induced aging mice via Akt/Nrf2/HO-1 pathway

Cited by 42 publications

References 41 publications

Dried bovine placenta improves spermatozoa count in a rat model of male reproductive aging

Dried bovine placenta improves spermatozoa count in a rat model of male reproductive aging

Assessment of in vivo antioxidant activity of a tripeptide Ala‐Tyr‐Ile fromJiuzao(a by‐product of baijiu distillation) protein hydrolysates and its stability in baijiu

Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease

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