Stevens–Johnson syndrome and toxic epidermal necrolysis: The Food and Drug Administration adverse event reporting system, 2004–2013

Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in vietnamese spontaneous adverse drug reaction database: A subgroup approach to disproportionality analysis

“…Many studies report female predominance, which is regarded as a risk factor . However, the reason why severe adverse reactions (especially SJS/TEN) are more common among women has not been elucidated to date .…”

“…Many studies report female predominance, which is regarded as a risk factor. 4,38,[45][46][47][48] However, the reason why severe adverse reactions (especially SJS/TEN) are more common among women has not been elucidated to date. 8 Our population-based study also shows that male patients were more likely to suffer SJS/TEN than their female counterparts-a marked difference compared to earlier studies of other population.…”

Stevens‐Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System

“…From January 2004 to March 2013, two AEDs were among the top medications listed in reports of SJS/TEN (lamotrigine and phenytoin). 40 The RORs were 20.4 (95% CI 19.2–21.8) and 12.0 (95% CI 11.3–12.7) for phenytoin and lamotrigine, respectively. As compared with our study, the risk associated with these AEDs were substantially lower than what we observed during a shorter and more recent time period (RORs, lamotrigine 53.0 versus 11.5 and 12.0, carbamazepine 24.5 versus 5.7, phenytoin 26.3 versus 20.4; time period, 2014–2017 versus 2004–2013/2015).…”

“…39, 40 Lamotrigine and carbamazepine were among the top five most common medications listed in reports for SJS/TEN in the Japanese Adverse Drug Event Report database over a 12-year period from April 2004 through April 2015. 39 Adjusted RORs were calculated for reporting year, gender, and age.…”

Drug induced exfoliative dermatitis: state of the art

“…Several authors reported also an increased incidence for aminopenicillins, cephalosporins, and quinolones [61, 62]. Drugs such as paracetamol, other non-oxicam NSAIDs and furosemide, bringing a relatively low risk of SJS/TEN a priori, are also highly prevalent as putative culprit agents in large SJS/TEN registries, due to their widespread use in the general population [63, 64] (Table 1). Rarely, Mycoplasma pneumoniae , dengue virus, cytomegalovirus, and contrast media may be the causative agent of SJS and TEN [22, 65–67].…”