Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in vietnamese spontaneous adverse drug reaction database: A subgroup approach to disproportionality analysis

Abstract

This first Vietnamese population-based study has highlighted original characteristics and signals of drug-induced SJS/TEN, which are relatively consistent with other worldwide data and typical for a developing country.

Severe Cutaneous Adverse Drug Reactions Associated with Allopurinol: An Analysis of Spontaneous Reporting System in Southern Italy

“…Except for few cases, SCARs usually occurred within the first 2 months from the beginning of the allopurinol therapy. In line with our findings, literature data showed that the TTE for drug-induced DRESS syndrome, SJS or TEN is extremely variable, ranging from 10 days to 2 months [38,39,62]. Therefore, the risk of developing these ADRs after drug exposure appears to be the greatest during the initial weeks of treatment.…”

“…This is not surprising because females seem to be more likely at risk to experience ADRs due to sex-specific differences in the pharmacokinetics and pharmacodynamics of drugs [34][35][36][37]. Furthermore, literature data confirm that both SJS and TEN could occur at any age, but appear to be more prevalent in adults, with a slight predominance in women [38,39]. In line with our findings, the results of two European studies based on the Portuguese Central Health System Administration and on the Spanish Pharmacovigilance database found that both SJS and TEN were more common in female patients [27,40].…”

Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9‐year experience in a tertiary care paediatric hospital setting

“…The total incidence of SCARs in hospitalized patients was 0.32% with median age at reaction of 6.5 years (range 1‐17) and SJS/TEN and AGEP mainly occurring in adolescents, consistently with the existing literature . There was no significant difference in the incidence between male and female children (M/F ratio 1.3:1); however, SJS was slightly prevalent in males (ratio 1.5:1), as well as in DRESS (M/F ratio 1.8:1), as reported elsewhere …”

“…In a recent review, Adler et al summarize three major algorithms to assess drug causality in SCARs: the Naranjo scale, the Algorithm of Drug Causality for Epidermal Necrolysis (ALDEN) for SJS/TEN, the European Registry of Severe Cutaneous Adverse Reactions to Drugs (RegiSCAR) criteria, the Japanese group of Severe Cutaneous Adverse Reactions to Drugs (SCAR‐J) criteria for DRESS, the European Study of Severe Cutaneous Adverse Reactions scoring system for AGEP . In literature, the rate of hospital admissions for SCARs is reported to be from 0.3 up to 3.6/1000 and many epidemiological studies focused on SCARs analysed incidence, demographic characteristics of patients, possible triggers and mortality rate in a hospital setting . In most of them, diagnosis was based on clinical features and history of drug administration, without allergy investigation, except for a few .…”

Acetaminophen‐induced atypical Stevens‐Johnson syndrome in a patient with acute oral bacterial infection: A case report and literature review

“…11 Similar to the findings reported in the current study, another study reported an acutely inflamed mandible due to a bacterial infection, resulting in pain and eating disorders, which resulted in conditions such as immunodeficiency. 13,18 However, there are few reports on the association between bacterial infections and SJS/TEN. 14 In the present study, although an oral infection was clinically diagnosed, the causative bacteria could not be identified because of negative results of the blood culture tests.…”