Stevens–Johnson syndrome and toxic epidermal necrolysis

Borchers, Andrea T.; Lee, Jennifer L.; Naguwa, Stanley M.; Cheema, Gurtej S.; Gershwin, M. Eric

doi:10.1016/j.autrev.2008.06.004

Cited by 173 publications

(172 citation statements)

References 37 publications

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“…Toxic epidermal necrolysis (Lyell's syndrome) is a severe toxicoallergic reaction with fever, formation of bubbles, epidermal rejection on more than 30% of body surface and visceral lesion [58]. The highest mortality is observed at Lyell's syndrome (40-80%, according to different authors) [54][55][56][57]. One of the key points of treating severe forms of drug allergy is as fast as possible withdrawal of the causative drug.…”

Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

“…The condition's severity and outcome depend on visceral lesion. Multiform exudative erythema-associated mortality is less than 1% [55][56][57]. Stevens-Johnson syndrome is characterized by involvement of mucous tunics (90%), conjunctiva (85%) and development of cavitary elements (vesicles, rarer -bubbles) in pathological process.…”

Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

“…Presence of all 7 criteria confirms diagnosis "typical drug-induced hypersensitivity syndrome"; presence of 5 criteria is considered to be a symptom of atypical drug-induced hypersensitivity syndrome. The most dangerous ADR are severe skin syndromes -multiform exudative erythema, StevensJohnson syndrome and toxic epidermal necrolysis (Lyell's syndrome) [30,[54][55][56][57]. It has been established that co-trimoxazole causes the mentioned reactions more often than any other modern ABD.…”

Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

“…Fever and flu-like symptoms often precede lesion of skin and mucous tunics by 1-3 days. Visceral involvement is prognostically unfavorable; mortality may reach 30% [54][55][56][57]. Toxic epidermal necrolysis (Lyell's syndrome) is a severe toxicoallergic reaction with fever, formation of bubbles, epidermal rejection on more than 30% of body surface and visceral lesion [58].…”

Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

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Allergy to Antibiotics in Children: Who Is to Blame and What to Do?

Andreeva¹,

Стецюк²

2013

Pediatr. farmakol.

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Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

Section: Clinical Manifestations Of the Allergy To Abdmentioning

confidence: 99%

See 2 more Smart Citations

Allergy to Antibiotics in Children: Who Is to Blame and What to Do?

Andreeva¹,

Стецюк²

2013

Pediatr. farmakol.

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“…The use of systemic corticosteroids is controversial because some cases are caused from severe infection and may this increase mortality. However, some case reports have shown the benefit of corticosteroids in reducing epidermal loss when given early in the course of the disease [3,4]. Other treatments have been used include intravenous immunoglobulin (IVIG), tumor necrosis factor-a inhibitors, cyclosporin, cyclophosphamide, plasmapheresis, and hemodialysis [3].…”

Section: Brief Communication (Original)mentioning

confidence: 99%

Stevens-Johnson Syndrome and toxic epidermal necrolysis in children: a retrospective study at Srinagarind Hospital, Khon Kaen, Thailand 1992–2012

Paipool

Sriboonnark

2015

Asian Biomedicine

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Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening skin conditions with an etiology of drug exposure or infections. Objectives: To determine the cause, treatments, complications, and outcomes of SJS/TEN in children admitted to Srinagrind Hospital during 1992−2012. Methods: Retrospective chart review. A diagnosis of SJS and TEN was confirmed by pediatric dermatologists. Results: A total of 38 patients was recorded. They consisted 31 (82%) SJS patients and 7 (18%) TEN patients. Mean age 6.6 years (range 1 to 14 years). Male to female was 1.1:1. Most cases (30 or 79%) were caused by drug exposure. Three cases (8%) by infection, and 5 cases (13%) were of unknown cause. The antiepileptic drug group was the most common cause. Systemic corticosteroids were used in 33 cases (87%). Intravenous immunoglobulin was used in one TEN patient (3%). There were 18 cases (47%) with acute complications. Ocular complications (7 cases, 39%), septicemia (4 cases, 22%), and secondary skin infections (3 cases, 17%) were the most common. Mean difference in length of hospital stay between those with and without acute complications was 12.3 days (P < 0.01, 95% CI 5.9-18.6). Ocular complications were the only long-term complications at 1-year follow up, and included symblepharon, corneal pannus, and dry eyes. Two patients (5%), both having cases of TEN, died. Conclusions: Antiepileptic drugs were the most common causes of SJS/TEN in our study. Good ophthalmologic care of the prevalent acute eye complications in these patients is needed to prevent long-term ophthalmic complications.

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High-Mobility Group Box 1 Protein (HMGB1) as a Novel Diagnostic Tool for Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

Nakajima¹,

Watanabe²,

Tohyama³

et al. 2011

Arch Dermatol

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and texture of scars in the setting of Mohs complex closures 2 to 3 months after surgery. To our knowledge, this is the first time that this has been demonstrated with a fractional ablative laser or in a prospective study. It is also the first time that this has been demonstrated on nonfacial sites, as shown in the Figure.Nine of the 10 subjects elected to have treatment of the control side with the laser at follow-up. It is a limitation that both sides of the scar were ultimately treated, which prevents longer-term evaluation.We have used this method to achieve minimal scarring on face-lift incision lines with excellent results. This work could potentially change the current approach in all surgical disciplines if these results can be validated with a long-term (6-12 months) multicenter study.

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Stevens–Johnson syndrome and toxic epidermal necrolysis

Cited by 173 publications

References 37 publications

Allergy to Antibiotics in Children: Who Is to Blame and What to Do?

Allergy to Antibiotics in Children: Who Is to Blame and What to Do?

Stevens-Johnson Syndrome and toxic epidermal necrolysis in children: a retrospective study at Srinagarind Hospital, Khon Kaen, Thailand 1992–2012

High-Mobility Group Box 1 Protein (HMGB1) as a Novel Diagnostic Tool for Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

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