Sterols from the fruit barks of Coelocaryon klainei Pierre ex Heckel (Myristicaceae)

Akoubet, Ouayogode Aminata; Marcelline, Adiko N’dri; Claude, Kablan Ahmont Landry; Sandrine, Aka Any-Grah; Coulibali, Siomenan; Léopold, Adjougoua Atoli; Guillaume, Kodjo Charles; Etienne, Effo Kouakou; Jacques, Konan Dibi; Jean-François, Kablan Richmond; Alette, Zialé Edwige; Barthélémy, Attioua Koffi; Diénéba, Koné Bamba

doi:10.3329/icpj.v6i9.34754

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…The genus Coelocaryon is used in traditional medicine to treat various diseases. The stem is traditionally taken as purgative [15] and its fruit is used as a spice by the people of the north-east of Côte d'Ivoire [16] and just like the fore mentioned plants it is traditionally used by the Nzema tribe of Ghana for the treatment of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Indigenous Knowledge Affords Antimicrobial Plants for the Management of Infections

Alake

Akwetey

Ahlidja

et al. 2021

IJTDH

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Aim: The research was carried out to ascertain the antimicrobial effect of the plants Omphalocarpum ahia, Homalium letestui, and Coelocaryon oxycarpum, which are used locally to treat some infectious diseases. Place and Duration of Study: Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana and Department of Herbal Medicine, KNUST, Ghana from June to August 2014. Method: The stem barks of the plants were extracted with 70 % methanol and successively partitioned with petroleum ether, ethyl acetate, methanol to obtain three different fractions. The antimicrobial activities of the extracts and fraction against MRSA, S. typhi, E. coli, S. pneumoniae, P. aeruginosa, E. faecalis, and S. aureus were determined using the disk diffusion method and the minimum inhibition concentration by the serial microplate dilution method with 0.2 mg/ml p-iodonitrotetrazolium as growth indicator whereas gentamycin was used as the positive control. Phytochemical tests on the plant materials were done according to standard methods. Result: All the fractions of each plant had activity against some of the bacteria. Ethyl acetate (EA) and hydro-methanolic (CE) extracts of Coelocaryon oxycarpum exhibited activity against all selected bacteria with MIC ranging from 0.625-5 mg/ml for CE and 0.3125-5 mg/ml for EA. Hydro-methanolic (CE) extracts of Omphalocarpum ahia also exhibited antibacterial activity against all the selected bacteria. Conclusion: The current research showed that Omphalocarpum ahia and Coelocaryon oxycarpum have considerable antimicrobial activity against all the strains used in the study. Local knowledge may afford lead materials for the development of novel antimicrobial agents.

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Section: Introductionmentioning

confidence: 99%

Indigenous Knowledge Affords Antimicrobial Plants for the Management of Infections

Alake

Akwetey

Ahlidja

et al. 2021

IJTDH

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Nutmegs and wild nutmegs: An update on ethnomedicines, phytochemicals, pharmacology, and toxicity of the Myristicaceae species

Barman

Bora

Saikia

et al. 2021

Phytotherapy Research

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Prized medicinal spice true nutmeg is obtained from Myristica fragrans Houtt. Rest species of the family Myristicaceae are known as wild nutmegs. Nutmegs and wild nutmegs are a rich reservoir of bioactive molecules and used in traditional medicines of Europe, Asia, Africa, America against madness, convulsion, cancer, skin infection, malaria, diarrhea, rheumatism, asthma, cough, cold, as stimulant, tonics, and psychotomimetic agents. Nutmegs are cultivated around the tropics for high‐value commercial spice, used in global cuisine. A thorough literature survey of peer‐reviewed publications, scientific online databases, authentic webpages, and regulatory guidelines found major phytochemicals namely, terpenes, fatty acids, phenylpropanoids, alkanes, lignans, flavonoids, coumarins, and indole alkaloids. Scientific names, synonyms were verified with http://www.theplantlist.org. Pharmacological evaluation of extracts and isolated biomarkers showed cholinesterase inhibitory, anxiolytic, neuroprotective, anti‐inflammatory, immunomodulatory, antinociceptive, anticancer, antimicrobial, antiprotozoal, antidiabetic, antidiarrhoeal activities, and toxicity through in‐vitro, in‐vivo studies. Human clinical trials were very few. Most of the pharmacological studies were not conducted as per current guidelines of natural products to ensure repeatability, safety, and translational use in human therapeutics. Rigorous pharmacological evaluation and randomized double‐blind clinical trials are recommended to analyze the efficacy and therapeutic potential of nutmeg and wild nutmegs in anxiety, Alzheimer's disease, autism, schizophrenia, stroke, cancer, and others.

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Sterols from the fruit barks of Coelocaryon klainei Pierre ex Heckel (Myristicaceae)

Cited by 2 publications

References 4 publications

Indigenous Knowledge Affords Antimicrobial Plants for the Management of Infections

Indigenous Knowledge Affords Antimicrobial Plants for the Management of Infections

Nutmegs and wild nutmegs: An update on ethnomedicines, phytochemicals, pharmacology, and toxicity of the Myristicaceae species

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