Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women

Abstract

Objectives Our aim was to investigate the prevalence and predictive variables of sarcopenia. Methods We recruited participants from the Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass was quantified using bioimpedance, and muscle function was quantified using grip strength and gait speed. Logistic regression revealed the relationships between sarcopenia and nutritional, lifestyle, disease, psychosocial and physical variables. Results The prevalence of sarcopenia and sarcopenic obesity was 9.2%‐16.2% and 0.26%‐9.1%, respectively. Old age, single status, undernourishment, higher income, smoking, low physical activity, poor appetite and low protein diets were significantly associated with sarcopenia. Multiple logistic regression analysis showed that age was a risk factor for all stages of sarcopenia, and participants above 80 years were greater than fivefold more susceptible to sarcopenia, while lower physical activity was an independent risk factor. The optimal cut‐off value for age was 71 years, which departs from the commonly accepted cut‐off of 60 years. Female participants were greater than twofold less susceptible to sarcopenia than male participants. The sterol derivative 25‐hydroxyvitamin D was associated with fourfold lower odds of sarcopenia in male participants. Several protein intake variables were also correlated with sarcopenia. Based on these parameters, we defined a highly predictive index for sarcopenia. Conclusions Our findings support a predictive index of sarcopenia, which agglomerates the complex influences that sterol metabolism and nutrition exert on male vs female participants.

Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study

“…Conversely, there was no difference in the serum vitamin D level between participants with or without sarcopenia among both men and women [ 32 , 33 ]. Li et al [ 34 ] reported that their sarcopenia group had significantly lower 25(OH)D than the non-sarcopenia group among men, but not women, which was similar to our results. Women in the present study had lower serum 25(OH)D than men; thus relationships might be estimated for different ranges of serum 25(OH)D for men and women [ 35 ].…”

Beneficial Effects of Walnut Oligopeptides on Muscle Loss in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Focusing on Mitochondrial Function

“…These findings are highly relevant for elderly and frail individuals or people who often experience inflammation and loss of muscle quality. Additionally, studies have confirmed that an increase in the intake of components with antioxidant and anti-inflammatory properties from diet or from supplementation could effectively prevent the negative impact of antioxidant deficiency, including oxidative status, lower muscle strength and muscle fatigue after an exercise challenge [ 14 , 21 , 45 , 46 , 47 ]. As typical bioactive peptides, WOPs have been shown to have great anti-inflammatory and antioxidative biological activities [ 24 , 25 , 26 , 27 , 28 ].…”

The Metabaging Cycle

“…18 Myocyte inflammation could lead to myocyte apoptosis, muscle proteolysis and fibrosis, all of which will accelerate sarcopenia. 19 At the physiological level, obesity and sarcopenia often coincide during aging, 20,21 and at the cellular level, lipotoxicity often coincides with myocyte and adipose inflammation. 22,23 In this process, adipose tissue and skeletal muscle could mutually influence each other by secreting pro-inflammatory factors, leading to a vicious cycle of metabolic impairment and further inflammation, which further spreads and progresses to systemic inflammation and IR.…”