Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study

Abstract

Purpose Regarding epidemiological studies, the role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly people is still controversial. The purpose of the present study was to investigate the associations between 25-hydroxyvitamin D [25(OH)D] and physical performance among community-dwelling middle-aged and old Japanese men and women. Methods The subjects were community-dwelling 297 men and 415 women aged 50 years and over. Data on height (m) and weight (kg) were collected. Serum 25(OH)D, parathyroid hormone, calcium, and albumin levels were measured. Serum 25(OH)D was classified into deficiency group: < 20 ng/mL, insufficiency group: 20–30 ng/mL, and sufficiency group: ≧ 30 ng/mL. Physical performance was assessed by grip strength, chair stand time, and functional reach. Information on current smoking, alcohol drinking, regular exercise, any comorbidities (hypertension, heart disease, diabetes mellitus, lung disease, and stroke), and pain (lumbar and knee) was collected. Results Vitamin D deficiency and insufficiency based on serum 25(OH)D levels were observed in 15.2% and 56.9% of men and 52.0% and 43.6% of women, respectively. In men, higher serum 25(OH)D levels were associated with better grip strength (p for trend = 0.003), chair stand time (p for trend = 0.042), and functional reach (p for trend <0.001). On the other hand, these parameters were not associated with serum 25(OH)D levels in women. Conclusion A higher level of serum 25(OH)D was associated with better physical performance in men but not in women.

Serological markers of sarcopenia in ages 65 and over

“…Вместе с тем в работе M. Uchiyama и соавт. связь с мышечной массой была установлена только у мужчин [8]. СП ассоциируется со слабым хроническим воспалением, одним из маркеров которого является СРБ.…”

Vitamin D Inadequacy Affects Skeletal Muscle Index and Physical Performance in Lumbar Disc Degeneration

“…Moreover, Uchiyama and coworkers have shown better physical performances, such as chair stand time, functional reach, and grip strength, among community-dwelling men with vitamin D sufficiency. It was postulated that an increase in serum 25(OH)D was associated with better physical performance [ 24 ]. A possible explanation for these discrepancies may include the low levels of serum 25(OH)D and VDR expression.…”

“…Iolascon et al reported that serum vitamin D status was negatively correlated with the SPPB walking speed test and the chair stand test in postmenopausal women [ 27 ]. Moreover, a previous study revealed a negative association between circulating 25(OH)D status and chair stand time in old Japanese men [ 24 ]. A possible explanation for the correlation between serum 25(OH)D and physical performance might be attributed to the imperative role of 1,25(OH)D or calcitriol, which promotes mitochondrial biogenesis in skeletal muscle cells [ 28 ] and controls calcium levels via regulating the function of calcium pumps and modulating muscle contraction and relaxation [ 25 ].…”

Association between fat mass by bioelectrical impedance analysis and bone mass by quantitative ultrasound in relation to grip strength and serum 25-hydroxyvitamin D in postmenopausal Japanese women: the Unzen study

“…Multiple linear regression analysis was used to explore the effects of fat mass and muscle mass on SI, with adjustment for age, height, comorbidity, current smoking, alcohol consumption, and exercise (Model 1) [11,28,29]. We added log (25(OH)D), log (TRACP-5b), log (PTH), and grip strength to model 1 (model 2) [30][31][32]. Statistical significance was set at p < 0 .05.…”