Steroids from an Australian Sponge Psammoclema sp.

Abstract

Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1-4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1-4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI(50) 5-27 microM). The additional insight that these new compounds give to previous SAR studies is discussed briefly.

Marine natural products

“…Andaman Sea, Thailand); 645 was weakly cytotoxic. 584 Petrosterol-3,6dione 660 and 5,6a-epoxy-petrosterol 661, isolated from Ianthella sp. 573 Heteronemin acetate, 574 12-O-deacetyl-19-deoxyscalarin 575 and sesterstatin-5 576 (Hyrtios erecta), were synthesised from heteronemin isolated from Hyrtios sp.…”

Cytotoxic compounds from Laurencia pacifica

“…In this area, we have identified a small family of cytotoxic steroids from an Australian sponge Psammoclema sp. [ 7 ], and antimalarial, antialgal, antitubercular, antibacterial, antiphotosynthetic, and antifouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi [ 8 ]. In this present study, we examined the cytotoxicity of extracts obtained from Laurencia pacifica algae collected in the pacific coast of the Baja California Peninsula, Mexico.…”

Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo

“…Holland et al isolated four new trihydroxysterols from the Australian sponge Psammoclema sp. and reported their cytotoxic activity in A2780 cells with IC 50 values ranging from 5.3 μM to 19 μM [17]. Leiodelide A, isolated from the deep-water marine sponge Leiodermatium , also showed cytotoxic activity (IC 50 = 0.25 μM) in OVCAR-3 cells.…”