Cytotoxic compounds from Laurencia pacifica

Zaleta-Pinet, Diana A.; Holland, Ian P.; Muñoz‐Ochoa, Mauricio; Murillo-Ãlvarez, J.I.; Sakoff, Jennette A.; Altena, Ian A. van; McCluskey, Adam

doi:10.1186/s13588-014-0008-8

Cited by 19 publications

(8 citation statements)

References 30 publications

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“…Isoaplysin 24 and debromoaplysinol 23 are two sesquiterpenes that differ in the presence of the C3a-hydroxymethyl instead of the C3a-bromomethyl moiety ( Figure 1 ). Compound 23 displays enhanced selectivity and broad spectrum cytotoxicity relative to 24 which, according to the authors, suggests that the hydroxyl group could play a significant role in the cytotoxicity of this class of compounds [ 45 ]. However, these compounds also have different configuration around the C3 and C8b chiral centers and that could explain the activity displayed.…”

Section: Secondary Metabolites From Seaweeds With In Vitro Cytotoxmentioning

confidence: 99%

“…Laurinterol 35 ( Figure 2 ), is a marine sesquiterpene isolated from a red alga Laurencia (Laurencia okamurae Yamada) [ 55 ], L. pacifica [ 45 ] , Laurencia nidifica J. Agardh [ 67 ] that structurally is very similar to a part of laurebiphenyl 20 ( Figure 1 ). Laurinterol 35 was reported for the first time as potential anticancer metabolite against melanoma cells (B16F1) with IC 50 value of 33.9 µM.…”

Section: Secondary Metabolites From Seaweeds With In Vitro Cytotoxmentioning

confidence: 99%

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Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

2018

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Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have carried out in vitro and in vivo studies in various cell lines and have disclosed the active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can be found in seaweeds. In this review the type of metabolites and their cytotoxic or antiproliferative effects will be discussed additionally their mode of action, structure-activity relationship and selectivity will also be revealed. The diterpene dictyolactone, the sterol cholest-5-en-3β,7α-diol and the halogenated monoterpene halomon are among the reported compounds, the ones that present sub-micromolar cytotoxicity. Additionally, one dimeric sesquiterpene of the cyclolaurane-type, three bromophenols and one halogenated monoterpene should be emphasized because they exhibit half maximal inhibitory concentration (IC50) values between 1–5 µM against several cell lines.

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Section: Secondary Metabolites From Seaweeds With In Vitro Cytotoxmentioning

confidence: 99%

Section: Secondary Metabolites From Seaweeds With In Vitro Cytotoxmentioning

confidence: 99%

Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

2018

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“…Taking into consideration the cytotoxic activity of Laurencia- derived metabolites [4,8,12,19,20,21,22], the rapid breast cancer increment, and the need for more effective drugs, we analyzed the antineoplastic effect of L1, the major compound isolated from L. johnstonii , using ex vivo organotypic cultures of human breast cancer explants.…”

Section: Introductionmentioning

confidence: 99%

Antitumoral Effect of Laurinterol on 3D Culture of Breast Cancer Explants

et al. 2019

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Macroalgae represent an important source of bioactive compounds with a wide range of biotechnological applications. Overall, the discovery of effective cytotoxic compounds with pharmaceutical potential is a significant challenge, mostly because they are scarce in nature or their total synthesis is not efficient, while the bioprospecting models currently used do not predict clinical responses. Given this context, we used three-dimensional (3D) cultures of human breast cancer explants to evaluate the antitumoral effect of laurinterol, the major compound of an ethanolic extract of Laurencia johnstonii. To this end, we evaluated the metabolic and histopathological effects of the crude extract of L. johnstonii and laurinterol on Vero and MCF-7 cells, in addition to breast cancer explants. We observed a dose-dependent inhibition of the metabolic activity, as well as morphologic and nuclear changes characteristic of apoptosis. On the other hand, a reduced metabolic viability and marked necrosis areas were observed in breast cancer explants incubated with the crude extract, while explants treated with laurinterol exhibited a heterogeneous response which was associated with the individual response of each human tumor sample. This study supports the cytotoxic and antitumoral effects of laurinterol in in vitro cell cultures and in ex vivo organotypic cultures of human breast cancer explants.

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“…Isoaplysin ( Figure. [33].The activation of the extrinsic apoptotic caspase-8 of polysaccharide-treated MDA-MB-231 induces apoptosis and causes cell death. The apoptotic signaling pathway was regulated via caspase-3, caspase-9, p53, Bax and Bcl-2 genes [34].…”

Section: Laurenciamentioning

confidence: 99%

Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.

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Cytotoxic compounds from Laurencia pacifica

Cited by 19 publications

References 30 publications

Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

Antitumoral Effect of Laurinterol on 3D Culture of Breast Cancer Explants

Algae as potential repository of anti cancerous natural compounds

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