Steroids and “steroid-like” substances in fish diets

Pelissero, C.; Sumpter, John P.

doi:10.1016/0044-8486(92)90078-y

Cited by 61 publications

(37 citation statements)

References 56 publications

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“…Phytoestrogens are also found in fish diet, both of commercial and natural origin, and could thus exert estrogenic effects on fish (Pelissero and Sumpter, 1992). We found that zearalenone and genistein bound to the ER with a higher affinity than the alkyphenols and the phthalates, displaying an apparent affinity of approximately 10 3 -fold less than that of estradiol.…”

Section: Discussionmentioning

confidence: 82%

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Knudsen

Pottinger

1998

Aquatic Toxicology

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Contact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trademarks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. AbstractThe ability of chemicals with known endocrine disrupting activity to interact with three major teleost steroid-binding sites was evaluated. Representative alkylphenols and phthalates, the pesticides dieldrin and toxaphene, the mycoestrogen zearalenone and the phytoestrogen genistein were tested for their ability to displace native ligand from putative estradiol receptor (ER), testosterone receptor (TR) and cortisol receptor (CR) from rainbow trout liver and brain. The ER displayed a higher affinity for alkylphenols than for phthalates, but both groups of compounds were 10 4 -2.10 5 times less potent than estradiol in displacing specifically bound

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Section: Discussionmentioning

confidence: 82%

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Knudsen

Pottinger

1998

Aquatic Toxicology

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“…14,15) In this study, we analyzed contents of isoflavones and their metabolites, genistein, daidzein, equol, and coumestrol in two commercial fish diets, TD and CD using LC-MS/ MS, and these contents were compared with that of FD. The contents of genistein, daidzein and coumestrol in CD were 390800 ng/g, 416800 ng/g and 1324.8 ng/g, respectively, and were highest and were lowest in FD.…”

Section: Discussionmentioning

confidence: 99%

Induction of Plasma Vitellogenin Synthesis by the Commercial Fish Diets in Male Goldfish(Carassius auratus) and Dietary Phytoestrogens.

Ishibashi

Kobayashi

Koshiishi

et al. 2002

JOURNAL OF HEALTH SCIENCE

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In this study, we analyzed contents of phytoestrogens (genistein, daidzein, equol, and coumestrol) in two commercial fish diets [a diet for trout (TD) and a diet for ornamental carp (CD)] using Liquid Chromatography-Mass Spectroscopy/Mass Spectroscopy (LC-MS/MS), and these contents were compared with that of a casein-based formulated fish diet (FD) which does not contain soya bean or fish meal. We also analyzed phytoestrogen contents in commercial infant casein-and soya bean-based diets. The contents of phytoestorogens were generally high in CD, TD, and soya milk, and low or non-detectable in FD and casein-based milks. Among these samples, CD showed the highest phytoestrogen contents: genistein, 390800 ng/g; daidzein, 416800 ng/g; coumestrol, 1325 ng/g; equol, 6.4 ng/ g. We also determined the estrogenic activity of the fish diets using male goldfish by measuring plasma vitellogenin (VTG) levels as a biomarker of estrogen exposure. When male goldfish were fed one of these diets for 31 days, plasma VTG was detected in CD-fed fish (78.01 ± 48.18 µg/ml) and TD-fed fish (3.51 ± 3.83 µg/ml), whereas plasma VTG was not detected in FD-fed fish (less than 0.040 µg/ml). These results indicate that the commercial fish diets examined contain a large amount of phytoestrogens and showed estrogenic activity that were strong enough to induce VTG production in male goldfish. It is necessary to eliminate estrogenic substances other than test chemicals in the screening test system for estrogenic endocrine-disrupting chemicals (EDCs). Since the formulated diet developed in the present study contain less phytoestrogens than the commercial fish diets and has low estrogenic activity, it is suggested that VTG production using male goldfish in combination with the low estrogen fish diet is a good in vivo system for evaluation of estrogenic effects of EDCs.

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“…Contamination of the water could occur via exposure to xenoestrogens (e.g., from plastic pipe work and tubing [20]) or via exposure to natural oestrogens released by female fish also present in the same water as the males [21]. This may be more apparent when fish are kept at high density with a recirculating water supply (e.g., in stock tanks) or in experiments with slow flow rates and thus long water replacement times [22].…”

Section: Introductionmentioning

confidence: 99%

“…Commercial fish diets contain high levels of protein, in the form of fish meal and soybean. Fish meal, which usually represents 15 to 40% of the diet [21], is prepared from several sources, including whole fish and fish viscera. Depending on the fish species and the sexual stage of the fish available, fish meal can contain high levels of sex steroid hormones, and Feist and Schreck [25] found that sex steroid levels in fish diets were correlated with the amount of fish by-products incorporated into them.…”

Section: Introductionmentioning

confidence: 99%

Estrogenic activity of tropical fish food can alter baseline vitellogenin concentrations in male fathead minnow (Pimephales promelas)

Beresford

Brian

Runnalls

et al. 2011

Enviro Toxic and Chemistry

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Abstract-Vitellogenin (VTG) is a precursor of egg-yolk protein and is therefore present at high concentrations in the plasma of female fish. In male fish, VTG concentrations are usually undetectable or low, but can be induced upon exposure to oestrogenic substances either via the water or the diet. This work was carried out to determine the reason for apparently elevated VTG concentrations in unexposed stock male fathead minnow maintained in our laboratory. The results showed clearly that some of the food given to the fish was oestrogenic and that replacement of this with non-oestrogenic food led to a significant reduction in the basal VTG levels measured in male fish after a 6 month period. This reduction in male VTG concentrations drastically increased the sensitivity of the VTG test in further studies carried out with these fish. Moreover, a review of published concentrations of VTG in unexposed male fathead minnow suggests that this problem may exist in other laboratories. The fathead minnow is a standard ecotoxicological fish test species and so these findings will be of interest to any laboratory carrying out fish tests on endocrine disrupting chemicals.

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Steroids and “steroid-like” substances in fish diets

Cited by 61 publications

References 56 publications

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Interaction of endocrine disrupting chemicals, singly and in combination, with estrogen-, androgen-, and corticosteroid-binding sites in rainbow trout (Oncorhynchus mykiss)

Induction of Plasma Vitellogenin Synthesis by the Commercial Fish Diets in Male Goldfish(Carassius auratus) and Dietary Phytoestrogens.

Estrogenic activity of tropical fish food can alter baseline vitellogenin concentrations in male fathead minnow (Pimephales promelas)

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