Steroids and related natural products—xxvii. Salvia apiana

Pettit, George R.; Klinger, Helmut; Jorgensen, Nels Otto N.; Occolowitz, John L.

doi:10.1016/s0031-9422(00)82144-5

Cited by 27 publications

(18 citation statements)

References 18 publications

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“…The isolated compounds were identified by their NMR and MS spectral analysis as four diterpenes: rosmadial ( I ) (Nakatani & Inatani 1983), carnosol ( II ) (Abreu et al 2008), 16-hydroxycarnosol ( III ) (Luis, Lahlou, Andrés, Sood, et al 1996), sageone ( IV ) (Tada et al 1994); two flavonoids: cirsimaritin ( V ) (Wang et al 2004), salvigenin ( VI ) (Ayatollahii et al 2009); and three triterpenes: oleanolic acid ( VII ) (Pettit et al 1966; Martins et al 2013), uvaol (3β,28-dihydroxy-urs-12-ene) ( VIII ) (Lee et al 2013), ursolic acid ( IX ) (Pettit et al 1966; Silva et al 2008). …”

Section: Resultsmentioning

confidence: 99%

“…The plant is used for diaphoretic and diuretic effects (Dentali & Hoffmann 1990). Previous to our research, several compounds including flavonoids, mono-, sesqui-, di- and tri terpenes, have been already identified and/or isolated from S. apiana (Pettit et al 1966; González et al 1992; Luis, Lahlou, & Andrés 1996; Luis, Lahlou, Andrés, Sood, et al 1996; Dentali & Hoffmann 1990; Borek et al 2006; Abreu et al 2008; Takeoka et al 2010). However, this plant has not been studied for cannabinoid or opioid receptors activity.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical and biological evaluation of Salvia apiana

Radhakrishnan

Hayes

Ross

2016

Natural Product Research

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Salvia apiana (white sage, Lamiaceae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections and poison oak rashes. The aqueous ethanolic extract of S. apiana showed moderate CB1 activity (58.3% displacement). Chromatographic purification of the ethanolic extract on silica gel column led to isolation of nine compounds: rosmadial (I), carnosol (II), 16-hydroxycarnosol (III), sageone (IV), cirsimaritin (V), salvigenin (VI), oleanolic acid (VII), 3β,28-dihydroxy-urs-12-ene (VIII), and ursolic acid (IX). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical and biological evaluation of Salvia apiana

Radhakrishnan

Hayes

Ross

2016

Natural Product Research

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“…Activity-guided fractionation of the petroleum ether and ethyl acetate extracts from the entire plant of A. unedo using the JB6 cell transformation assay provided one new compound (1) and nine known compounds, namely, -amyrin acetate (2) [12], betulin [13], betulinic acid (5) [14], (À)-catechin (6) [15], 6-hydroxystigmast-4-en-3-one [16], lupeol (3) [17], platanic acid [18], pomolic acid 3-acetate (4) [19], and -sitosterol [20] (figure 1). Of these compounds, only betulinic acid (5) and betulin have been isolated previously from A. unedo [5].…”

Section: Resultsmentioning

confidence: 99%

Potential cancer chemopreventive agents fromArbutus unedo

Carcache‐Blanco

Cuendet

Park

et al. 2006

Natural Product Research

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A phytochemical study of the petroleum ether and ethyl acetate extracts of the entire plant of Arbutus unedo led to the isolation of a new sterol, 7beta-hydroxystigmast-4-en-3-one (1), and nine known compounds of the flavan, steroid, and terpenoid types. The structure of 1 was determined by spectroscopic data interpretation in combination with molecular modeling calculations. The absolute stereochemistry of C-7 was assigned as S for compound 1 based on the obtained CD spectral data. Activity in the JB6 cell transformation assay was found for pomolic acid 3-acetate (4). All isolates obtained were evaluated in a cyclooxygenase-2 (COX-2) inhibition assay.

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“…The existing literature for S. apiana discusses the extraction and identification of triterpenes and related constituents found in the roots of this plant. [9][10][11] We respectfully submit this information as the first report of the assay of the essential oil of S. apiana.…”

Section: Gas Chromatography-fidmentioning

confidence: 99%

Composition of the essential oil of white sage, Salvia apiana

Borek

Hochrien

Irwin

2006

Flavour & Fragrance J

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KEY WORDS: Salvia apiana; white sage; essential oil composition; 1,8-cineole Gas Chromatography-Mass SpectrometryThe dilutions used for GC-FID were also used for GC-MS. The GC-MS analysis was performed on an Agilent 6890/5973N instrument, using a DB-5MS column (30 m × 0.25 mm i.d., 1 µm film thickness); carrier gas, helium at a constant flow of 1.2 ml/min; injection, 0.2 µl; sample split, 50:1; injector temperature, 280°C; GC oven temperature programme, 35°C for 2 min, rising at 5°C/min to 280°C, then held at 280°C for 2 min. The mass spectrometer conditions were: source temperature, 230°C, quadrupole, 150°C; solvent delay, 2.20 min; scan, 33-280 amu for the first 12.2 min, then 33-388 amu for the duration of the analysis. A preliminary analysis was performed using a Finnigan Mat SSQ710 instrument with an A200S autosampler, using a DB-5MS column (60 m × 0.25 mm i.d., 1 µm film thickness); carrier gas, helium at a constant pressure of 37 p.s.i.; injector temperature, 250°C; GC oven temperature programme, 50°C for 5 min, rising to 300°C at a rate of 25°C/ min, then held at 300°C for 10 min. The MS conditions were: source temperature, 150°C; manifold temperature, 70°C; mass range, 33-350; scan time, 0.5 s.

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Steroids and related natural products—xxvii. Salvia apiana

Cited by 27 publications

References 18 publications

Phytochemical and biological evaluation of Salvia apiana

Phytochemical and biological evaluation of Salvia apiana

Potential cancer chemopreventive agents fromArbutus unedo

Composition of the essential oil of white sage, Salvia apiana

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