Steroidal saponins from Smilax excelsa rhizomes

Abstract

From the n-butanol soluble fraction of the methanol extract of the rhizomes of Smilax excelsa, three new furostanol saponins 3-O-[4-O-acetyl-alpha-L-rhamnopyranosyl-(1 --> 2)-{alpha-L-rhamnopyranosyl-(1 --> 4)}-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22alpha-hydroxy-(25R)-furost-5-ene-3beta,26-diol (1), 3-O-[2-O-acetyl-alpha-L-rhamnopyranosyl-(1 --> 2)-{alpha-L-rhamnopyranosyl-(1 --> 4)}-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22alpha-hydroxy-(25R)-furost-5-ene-3beta,26-diol (2), 3-O-[3-O-acetyl-alpha-L-rhamnopyranosyl-(1 --> 2)-{alpha-L-rhamnopyranosyl-(1 --> 4)}-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22alpha-hydroxy-(25R)-furost-5-ene-3beta,26-diol (3), and three known saponins: protodioscin (4), pseudoprotodioscin (5) and dioscin (6) were isolated.

Intraspecific Variability of Main Phytochemical Compounds inTribulus TerrestrisL. from North Bulgaria

“…the data for the biological activity of this compound are limited. it has been reported that the methyl-prototribestin is the most effective resistance modifier against human mdr1 gene-transfected mouse lymphoma cell line (2). the content of dioscin in the studied samples was from 2.33 mg/g (Bulgarevo Village) to 0.64 mg/g (cherkovitza Village).…”

Diuretic activity of some Smilax canariensis fractions

“…Thus a large amount of experimental data clearly demonstrated that plants in this genus have interesting anticancer, cytotoxic, anticonvulsant, antioxidant, antidiabetic, antimicrobial, antiviral, anti-inflammatory and antinociceptive properties, among others (Shu et al, 2006;Ooi et al, 2008;Ozsoy et al, 2008;Zhang et al, 2008;Jagessar et al, 2009;Khan et al, 2009;Laitonjam and Kongbrailatpam, 2010;Venkidesh et al, 2010;Wu et al, 2010;Xia et al, 2010;Anita et al, 2011;Ivanova et al, 2011;Vijayalakshmi et al, 2011). Other studies have shown that Smilax species contain mainly polar compounds such as flavonoids and steroidal saponins (Ivanova et al, 2009;Huang et al, 2009;Shao et al, 2009;Zhou et al, 2009).…”

Steroidal Saponins from the Genus Smilax and Their Biological Activities

“…Diosgenin-3- O - α - l -rhamnopyranoside ( 12 ) was the first diosgenin glycoside reported from the epigeal part of S. excelsa in 1975 [12]. Dioscin ( 13 ) was widely distributed among the Smilax species, including S. china [8], S. menispermoidea [13], S. lebrunii [14], S. nigrescens [15], S. stans [16], S. excels [17], S. microphylla [18], and S. bockii [19]. Parisyunnanosides C–E ( 18 – 20 ), with hydroxyl substitutions at C-7 or C-12, were isolated from the stems of S. riparia [20].…”