Steroidal estrogens of Prunus armeniaca seeds

Awad, Olfat

doi:10.1016/s0031-9422(00)91390-6

Cited by 17 publications

(3 citation statements)

References 10 publications

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“…Estrogenically active substances were subsequently isolated in crystalline form from palm kernels [72] and willow catkins [73]. Various authors later confirmed the presence of steroidal estrogens in many plant species including date palm, bean, pomegranate, and the species of the Prunus genus [53,56,74,75,76,77,78]. Although numerous authors have described the presence of steroidal estrogens as well as their biosynthetic pathway, some authors have, historically, disputed their presence in plants [79,80].…”

Section: Estrogensmentioning

confidence: 99%

Plants are Capable of Synthesizing Animal Steroid Hormones

Tarkowská

2019

Molecules

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As a result of the findings of scientists working on the biosynthesis and metabolism of steroids in the plant and animal kingdoms over the past five decades, it has become apparent that those compounds that naturally occur in animals can also be found as natural constituents of plants and vice versa, i.e., they have essentially the same fate in the majority of living organisms. This review summarizes the current state of knowledge on the occurrence of animal steroid hormones in the plant kingdom, particularly focusing on progesterone, testosterone, androstadienedione (boldione), androstenedione, and estrogens.

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Section: Estrogensmentioning

confidence: 99%

Plants are Capable of Synthesizing Animal Steroid Hormones

Tarkowská

2019

Molecules

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“…In addition to the above HAPs, plants produce several compounds typically thought of as vertebrate sex steroids, their metabolites, and the enzymes necessary to synthesize them (Hewitt, Hillman, & Knights, ; Janeczko & Skoczowski, ; Simersky, Novak, Morris, Pouzar, & Strnad, ). Estradiol and estrone have been detected in seeds or pollen of apples, date and doum palm, plums, and pomegranates (Amin, Awad, El Samad, & Iskander, ; Amin & Paleologou, ; Awad, ; Bennett, Ko, & Heftmann, ; Gawienowski & Gibbs, ; Heftmann, Ko, & Bennett, ) as well as quaking aspen catkins (Khaleel, Dillman, & Gretch, ), common beans (Kopcewicz, ), moghat roots (Amin et al., ), and waxyleaf nightshade (Milanesi, Monje, & Boland, ). Similarly, progesterone was found in extracts of loblolly pine, common foxglove, tobacco, and elecampane (Carson, Jenkins, Wilson, Howell, & Moore, ; Simersky et al., ); 17‐alpha‐hydroxyprogesterone and 16‐dehydro‐progesterone occurred at significant concentrations in foxglove ; and androstenedione was found in tobacco and elecampane (Simersky et al., ).…”

Section: Haps: What and Where They Arementioning

confidence: 99%

Hormonally active phytochemicals and vertebrate evolution

Lambert

Edwards

2017

Evolutionary Applications

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Living plants produce a diversity of chemicals that share structural and functional properties with vertebrate hormones. Wildlife species interact with these chemicals either through consumption of plant materials or aquatic exposure. Accumulating evidence shows that exposure to these hormonally active phytochemicals (HAPs) often has consequences for behavior, physiology, and fecundity. These fitness effects suggest there is potential for an evolutionary response by vertebrates to HAPs. Here, we explore the toxicological HAP–vertebrate relationship in an evolutionary framework and discuss the potential for vertebrates to adapt to or even co‐opt the effects of plant‐derived chemicals that influence fitness. We lay out several hypotheses about HAPs and provide a path forward to test whether plant‐derived chemicals influence vertebrate reproduction and evolution. Studies of phytochemicals with direct impacts on vertebrate reproduction provide an obvious and compelling system for studying evolutionary toxicology. Furthermore, an understanding of whether animal populations evolve in response to HAPs could provide insightful context for the study of rapid evolution and how animals cope with chemical agents in the environment.

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“…Prunus armeniaca L., a fragrant and flavorful apricot belonging to the Rosaceae family, has its origins in Central Asia and is widely distributed around the world [ 14 , 15 ]. According to published reports, many secondary metabolites, such as steroids, norisoprenoids, terpenoids, proanthocyanidins, and phenolic compounds, have been isolated and structurally elucidated in many parts of P. armeniaca [ 16 , 17 ]. Amygdalin (AD), a cyanogenic glycoside isolated from P. armeniaca , was reported to exhibit various pharmacological effects, such as anti-fibrosis, anti-inflammation, analgesia, auxiliary anticancer, immunoregulation, anti-atherosclerosis, anti-cardiac hypertrophy, anti-ulcer, hypoglycemia effects, anticholinesterase, and neuroprotective activities [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Effect on Osteoclast Differentiation and ER Stress Downregulation by Amygdalin and RANKL Binding Interaction

et al. 2022

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Bone diseases such as osteoporosis are the result of osteoclast over-activation. There are many therapeutic agents from natural compounds inhibiting the formation of osteoclast that have been reported and are continuously being interested. Amygdalin (AD) is isolated from seeds of Prunus armeniaca L. which has many pharmaceutical effects; however, the effect of AD on osteoclast formation and function remains unknown. Therefore, the underlying mechanism of AD on RANKL-induced osteoclast in RAW 264.7 cells was investigated. Molecular docking simulation revealed that AD can bind to the active sites of RANKL with negative binding affinities. Through TRAP activity, bone resorption, and migration, AD effectively inhibited osteoclast differentiation and function. Expression of transcription factors, such as NFATc1, c-fos, and osteospecific genes (including dcstamp, acp5, ATP6v0d2, and ctsk results) showed an osteoclast differentiated inhibitory effect by AD treatment. In addition, RANKL-induced activation of MAPK, ER stress, and ROS levels in RANKL-induced osteoclast was significantly inhibited while antioxidant enzymes were recovered in the presence of AD. These results suggest that AD may be a potential candidate derived from natural sources for the treatment of osteoclast bone-related diseases.

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Steroidal estrogens of Prunus armeniaca seeds

Cited by 17 publications

References 10 publications

Plants are Capable of Synthesizing Animal Steroid Hormones

Plants are Capable of Synthesizing Animal Steroid Hormones

Hormonally active phytochemicals and vertebrate evolution

Effect on Osteoclast Differentiation and ER Stress Downregulation by Amygdalin and RANKL Binding Interaction

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