Steroid use in idiopathic sudden sensorineural hearing loss

Moskowitz, Dan; Lee, K. J.; Smith, Howard W.

doi:10.1288/00005537-198405000-00016

Cited by 250 publications

(227 citation statements)

References 5 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…The concept that autoimmunity might damage the labyrinth resulting in bilateral, progressive sensorineural hearing loss (SNHL) was introduced in McCabe (1979). Autoimmunity has since been proposed as an etiology for Meniere's disease (Hughes et al, 1988), sudden SNHL (Moskowitz et al, 1984), and acute vertigo (Hughes et al, 1985). These and other data provide evidence that immune mechanisms and their associated inflammatory response can cause damage to sensitive auditory and/or vestibulary cells.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory signals increase Fas ligand expression by inner ear cells

Bodmer

Brors²,

Pak³

et al. 2002

Journal of Neuroimmunology

View full text Add to dashboard Cite

There is considerable evidence that hearing and vestibular function can be influenced by immune processes. The inner ear has evolved mechanisms, such as the blood-labyrinthine barrier that limit immune responses and autoimmune processes to reduce the potential for damage to cochlear cells. Recently, expression of Fas ligand (FasL) in some non-lymphoid tissue, as in the anterior chamber of the eye, has been hypothesized to play a role in protection of sensitive organs from activated T-cells. We show that under resting conditions, cochlear cells express little or no FasL. However, after exposure to interferon-gamma in vitro, FasL is induced in many neonatal cochlear cells. In addition, we show that FasL is upregulated in adult cochlear cells after induction of a sterile labyrinthitis in vivo. The induction of FasL by inflammation may serve to limit cochlear immune responses, and to protect sensorineural tissue from immune and autoimmune damage. AbstractThere is considerable evidence that hearing and vestibular function can be influenced by immune processes. The inner ear has evolved mechanisms, such as the blood -labyrinthine barrier that limit immune responses and autoimmune processes to reduce the potential for damage to cochlear cells. Recently, expression of Fas ligand (FasL) in some non-lymphoid tissue, as in the anterior chamber of the eye, has been hypothesized to play a role in protection of sensitive organs from activated T-cells. We show that under resting conditions, cochlear cells express little or no FasL. However, after exposure to interferon-g in vitro, FasL is induced in many neonatal cochlear cells. In addition, we show that FasL is upregulated in adult cochlear cells after induction of a sterile labyrinthitis in vivo. The induction of FasL by inflammation may serve to limit cochlear immune responses, and to protect sensorineural tissue from immune and autoimmune damage. D

show abstract

Section: Discussionmentioning

confidence: 99%

Inflammatory signals increase Fas ligand expression by inner ear cells

Bodmer

Brors²,

Pak³

et al. 2002

Journal of Neuroimmunology

View full text Add to dashboard Cite

show abstract

“…Drugs are commonly delivered systemically, with the hope that they will find their way to their intended inner ear targets in the form and concentration desired, and without serious side effects. Systemic corticosteroids, for example, are used in the otologic management of idiopathic sudden and immune-mediated sensorineural hearing losses (e.g., [51][52][53]). Their clinical usefulness, however, is limited by undesirable side effects arising from the high systemic doses required to achieve sufficient cochlear fluid levels of drug to produce the intended inner ear effects [54].…”

Section: Comparison To Other Delivery Methodsmentioning

confidence: 99%

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

Chen

Kujawa

McKenna

et al. 2005

Journal of Controlled Release

View full text Add to dashboard Cite

Rapid progress in understanding the molecular mechanisms associated with cochlear and auditory nerve degenerative processes offers hope for the development of gene-transfer and molecular approaches to treat these diseases in patients. For therapies based on these discoveries to become clinically useful, it will be necessary to develop safe and reliable mechanisms for the delivery of drugs into the inner ear, bypassing the blood-labyrinthine barrier. Toward the goal of developing an inner ear perfusion device for human use, a reciprocating microfluidic system that allows perfusion of drugs into the cochlear perilymph through a single inlet hole in scala tympani of the basal turn was developed. The performance of a prototype, extracorporeal reciprocating perfusion system in guinea pigs is described. Analysis of the cochlear distribution of compounds after perfusion took advantage of the place-dependent generation of responses to tones along the length of the cochlea. Perfusion with a control artificial perilymph solution had no effect. Two drugs with wellcharacterized effects on cochlear physiology, salicylate (5 mM) and DNQX (6,7-Dinitroquinoxaline-2,3-dione; 100 and 300 μM), reversibly altered responses. The magnitude of drug effect decreased with distance from the perfusion pipette for up to 10 mm, and increased with dose and length of application.

show abstract

“…A participação de auto-imunidade em doenças do ouvido interno como surdez neurossensorial progressiva (35) , vertigem aguda (36) e doença de Menière (37) foi previamente descrita. Em particular, reatividade contra Hsp de 70 kDa foi reportada em pacientes com surdez neurossensorial progressiva (38,39) .…”

Section: Anticorpos Anti-hsp E Auto-imunidadeunclassified

Anticorpos contra proteínas de choque térmico, autoimunidade e aterosclerose

Lottermann¹,

Ranzolin²,

Mühlen³

et al. 2003

Rev. Bras. Reumatol.

View full text Add to dashboard Cite

RESUMOAs proteínas de choque térmico (heat-shock proteins -Hsp) são estruturas ubíquas e conservadas na evolução das espécies. São sintetizadas por uma grande variedade de seres vivos. Enquanto algumas são constitutivas, outras são marcadores de estresse celular. Há considerável homologia molecular entre Hsp bacterianas e humanas. Este mimetismo antigênico pode induzir a sínte-se de anticorpos cruzados a partir de infecções. Anticorpos contra várias Hsp são detectáveis em doenças do tecido conjuntivo (DTC) e doenças auto-imunes do ouvido interno. O significado patogênico destes achados é ainda discutível. A Hsp de 65 kilodaltons (kDa) é componente da placa aterosclerótica. Em anos recentes, anticorpos anti-Hsp de 60/65 kDa foram associados ao deflagramento do processo aterosclerótico. Nesta revisão, discutimos os achados acerca destes anticorpos tanto em doenças autoimunes como na aterosclerose coronária e cerebral.

show abstract

Steroid use in idiopathic sudden sensorineural hearing loss

Cited by 250 publications

References 5 publications

Inflammatory signals increase Fas ligand expression by inner ear cells

Inflammatory signals increase Fas ligand expression by inner ear cells

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

Anticorpos contra proteínas de choque térmico, autoimunidade e aterosclerose

Contact Info

Product

Resources

About