Steroid Regulation of Vasoactive Intestinal Peptide (VIP)

Rostène, William; Mn, Montagne; Dussaillant, Monique; Gozes, Illana

doi:10.3109/10253899709014739

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…Interestingly, alcohol induces ligand-independent activation of the estrogen receptor alpha [61]. Estrogen regulates multiple genes, including the sexually dichotomous ADNP regulator, vasoactive intestinal peptide (VIP) [39,51,62,63]. The VIP gene has a cAMP/CREB responsive element [64], and in turn, increases cAMP production in the target cells [65], bringing another connection to the CREB regulatory protein and alcohol consumption [11].…”

Section: Discussionmentioning

confidence: 99%

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice

Ziv

Rahamim

Lezmy

et al. 2018

Neuropsychopharmacol

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Neuroadaptations in the brain reward system caused by excessive alcohol intake, lead to drinking escalation and alcohol use disorder phenotypes. Activity-dependent neuroprotective protein (ADNP) is crucial for brain development, and is implicated in neural plasticity in adulthood. Here, we discovered that alcohol exposure regulates Adnp expression in the mesolimbic system, and that Adnp keeps alcohol drinking in moderation, in a sex-dependent manner. Specifically, Sub-chronic alcohol treatment (2.5 g/kg/day for 7 days) increased Adnp mRNA levels in the dorsal hippocampus in both sexes, and in the nucleus accumbens of female mice, 24 h after the last alcohol injection. Long-term voluntary consumption of excessive alcohol quantities (~10-15 g/kg/24 h, 5 weeks) increased Adnp mRNA in the hippocampus of male mice immediately after an alcohol-drinking session, but the level returned to baseline after 24 h of withdrawal. In contrast, excessive alcohol consumption in females led to long-lasting reduction in hippocampal Adnp expression. We further tested the regulatory role of Adnp in alcohol consumption, using the Adnp haploinsufficient mouse model. We found that Adnp haploinsufficient female mice showed higher alcohol consumption and preference, compared to Adnp intact females, whereas no genotype difference was observed in males. Importantly, daily intranasal administration of the ADNP-snippet drug candidate NAP normalized alcohol consumption in Adnp haploinsufficient females. Finally, female Adnp haploinsufficient mice showed a sharp increase in alcohol intake after abstinence, suggesting that Adnp protects against relapse in females. The current data suggest that ADNP is a potential novel biomarker and negative regulator of alcohol-drinking behaviors.

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Section: Discussionmentioning

confidence: 99%

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice

Ziv

Rahamim

Lezmy

et al. 2018

Neuropsychopharmacol

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show abstract

“…As suggested above, VIP gene expression may be regulated by steroids (Gozes et al 1994b;Rostene et al 1997). VIP promoter sequences also demonstrated glucocorticoid response.…”

Section: Regulation Of Vip Expressionmentioning

confidence: 91%

VIP, From Gene to Behavior and Back: Summarizing my 25 Years of Research

Gozes

2008

J Mol Neurosci

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Vasoactive intestinal peptide (VIP) is an interesting example of a 28-amino acid neuropeptide that is abundantly expressed in discrete brain regions/neurons and hence may contribute to brain function. This short review summarizes my own point of view and encompasses 25 years of work and over 100 publications targeting the understanding of VIP production and biological activity. The review starts with our original cloning of the VIP gene, it then continues to discoveries of regulation of VIP synthesis and the establishment of the first VIP transgenic mice. The review ends with the identification of novel VIP analogs that helped decipher VIP's important role during development, in regulation of the biological clock(s) and diurnal rhythms, sexual activity, learning and memory as well as social behavior, and cancer. This review cites only articles that I have coauthored and gives my own perspective of this exciting ever-growing field.

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Potential clinical applications of vasoactive intestinal peptide: a selected update

Gozes

Furman

2004

Best Practice & Research Clinical Endocrinology & Metab

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Steroid Regulation of Vasoactive Intestinal Peptide (VIP)

Cited by 3 publications

References 64 publications

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice

VIP, From Gene to Behavior and Back: Summarizing my 25 Years of Research

Potential clinical applications of vasoactive intestinal peptide: a selected update

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