Potential clinical applications of vasoactive intestinal peptide: a selected update

Gozes, Illana; Furman, Sharon

doi:10.1016/j.beem.2004.08.006

Cited by 24 publications

(11 citation statements)

References 114 publications

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“…It was additionally proven that intraperitoneal injection of VIP prevented stress-induced gastric ulcer formation by inhibiting mast cell degranulation and preventing lipid peroxidation (Tuncel et al 1998). Due to its anti-inflammatory properties, VIP has been successfully applied as a therapeutic agent in multiple pathologies, such as heart failure, primary pulmonary hypertension, type 2 diabetes, and gastrointestinal motility disorders (Gozes and Furman 2003; Gozes and Furman 2004), and may be a candidate for treatment of various inflammatory processes. Our finding of increased expression of PACAP and VIP in the porcine vagal neurons as a consequence of aspirin-induced gastritis provides convincing evidence of the special role of both peptides in neuronal response to gastric pathology and confirms the pig as a good animal model for a PACAP/VIP anti-inflammatory preclinical study.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Acetylsalicylic-Acid-Supplementation-Induced Gastritis Affects the Chemical Coding of the Stomach Innervating Vagal Efferent Neurons in the Porcine Dorsal Motor Vagal Nucleus (DMX)

Gańko

Całka

2014

J Mol Neurosci

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The main goal of our research was to study the possible alterations of the chemical coding of the dorsal motor vagal nucleus (DMX) neurons projecting to the porcine stomach prepyloric region following prolonged acetylsalicylic acid supplementation. Fast Blue (FB) was injected into the studied area of the stomach. Since the seventh day following the FB injection, acetylsalicylic acid (ASA) was given orally to the experimental gilts. All animals were euthanized on the 28th day after FB injection. Medulla oblongata sections were then processed for double-labeling immunofluorescence for choline acetyltransferase (ChAT), pituitary adenylate cyclase-activating peptide (PACAP), vasoactive intestinal polypeptide (VIP), nitric oxide synthase (NOS), galanin (GAL), substance P (SP), leu enkephalin (LENK), and cocaine- and amphetamine-regulated transcript (CART). In the control DMX, only PACAP was observed in 30.08 ± 1.97 % of the FB-positive neurons, while VIP, NOS, GAL, SP, LENK, and CART were found exclusively in neuronal processes running between FB-labeled perikarya. In the ASA DMX, PACAP was revealed in 49.53 ± 5.73 % of traced vagal perikarya. Moreover, we found de novo expression of VIP in 40.32 ± 7.84 %, NOS in 25.02 ± 6.08 %, and GAL in 3.37 ± 0.85 % of the FB-labeled neurons. Our results suggest that neuronal PACAP, VIP, NOS, and GAL are mediators of neural response to aspirin-induced stomach inflammatory state.

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Section: Discussionmentioning

confidence: 99%

Prolonged Acetylsalicylic-Acid-Supplementation-Induced Gastritis Affects the Chemical Coding of the Stomach Innervating Vagal Efferent Neurons in the Porcine Dorsal Motor Vagal Nucleus (DMX)

Gańko

Całka

2014

J Mol Neurosci

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“…The VIPR family includes 2 subtypes: VIPR-1 and VIPR-2 (Gozes and Furman, 2004). Both are G protein-coupled receptors that can activate adenylate cyclase.…”

Section: Discussionmentioning

confidence: 99%

Vasoactive intestinal polypeptide suppresses proliferation of human cord blood-derived hematopoietic progenitor cells by increasing TNF-α and TGF-β production in the liver

Wang¹,

Xiao²,

Wang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The physiology of hepatic hematopoiesis is largely unknown, although studies have indicated that vasoactive intestinal polypeptide (VIP) is involved in this disease. To validate this hypothesis, we assessed the effects of VIP on human cord blood CD34 + cells. We also measured VIP levels and the capacity of vasoactive intestinal polypeptide receptor (VIPR) to bind to VIP in the rat liver during different developmental phases. VIP inhibited the proliferation of cord blood-derived CD34 + cells from concentrations of 10 -7 -10 -12M. The highest suppression was achieved with 10 -8 M VIP at day 10. + cells treated with VIP were increased by 50.70 and 43.46%, respectively. Variations in VIP levels in the rat fetal liver generally increased rapidly with the stage of fetal development. In addition, the affinity of VIPR for VIP increased from relatively low levels in the rat fetal liver and peaked at birth, after which it gradually decreased. VIP had a suppressive effect on the proliferation of human cord blood-derived CD34 + cells, partially by increasing the production of TNF-α and TGF-β. Low VIP levels in the fetal liver and gradually increasing levels after birth may in part be responsible for suppressing hematopoietic stem cell and progenitor proliferation in the liver.

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“…VIP exerts multiple actions tending to counteract some of the pathways of inflammation and apoptosis and, thus, to promote cell survival. VIP is the major neuropeptide with neurotrophic, neurotransmitter, neuromodulatory, antioxidant, antiinflammatory, and antiapoptotic properties (Said 1996;Said and Dickman 2000;Dogrukol-Ak et al 2004;Gozes and Furman 2004). The previous studies showed that VIP protects tissues from injury against several diseases including ischemia-reperfusion injury, sepsis, hemorrhage, colitis, asthma, rheumatoid arthritis, Parkinson disease, and Alzheimer's disease (Tikiz et al 1992;Said et al 1995;Erden et al 1998;Tunçel and Töre 1998;Tunçel et al 2000Tunçel et al , 2005Tore et al 2001;Can et al 2004;Szema et al 2006;Arranz et al 2008a, b).…”

Section: Introductionmentioning

confidence: 91%

The Effects of Vasoactive Intestinal Peptide on Dura Mater Nitric Oxide Levels and Vessel-Contraction Responses in Sympathectomized Rats

et al. 2009

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Nitric oxide (NO) and neurogenic inflammation in dura mater due to nociceptor activation has been implicated for pathophysiology of primary headache disorders. Development of migraine has also been observed in patients treated with ganglion blockage for sympathetic reflex dystrophy. Vasoactive intestinal peptide (VIP) is an antioxidant, anti-inflammatory, and neuroprotective neuropeptide. This study is intended to investigate the effects of VIP on dura mater NO levels and vessel-contraction responses in sympathectomized rats. In the experiments, 30 male rats in five groups were used. Group 1 sympathectomized: under anesthesia, superior cervical sympathetic ganglion was removed via incision at the center line in the neck area. Group 2 sympathectomized + VIP: postoperative VIP of 25 ng/kg/day (0.2 ml) intraperitoneally administered to the rats exposed to the same operations for 5 days. Group 3 sham: ganglia and nerves were exposed but not dissected. Group 4 control: no treatment was done. Group 5 VIP: only VIP was administered for 5 days. Sympathectomy induced a significant increase in dura mater NO levels and VIP decreased NO to control levels and increased the norepinephrine vessel-contraction responses of sympathectomized rats. VIP is an efficient NO modulator in superior cervical ganglionectomized rats.

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Potential clinical applications of vasoactive intestinal peptide: a selected update

Cited by 24 publications

References 114 publications

Prolonged Acetylsalicylic-Acid-Supplementation-Induced Gastritis Affects the Chemical Coding of the Stomach Innervating Vagal Efferent Neurons in the Porcine Dorsal Motor Vagal Nucleus (DMX)

Prolonged Acetylsalicylic-Acid-Supplementation-Induced Gastritis Affects the Chemical Coding of the Stomach Innervating Vagal Efferent Neurons in the Porcine Dorsal Motor Vagal Nucleus (DMX)

Vasoactive intestinal polypeptide suppresses proliferation of human cord blood-derived hematopoietic progenitor cells by increasing TNF-α and TGF-β production in the liver

The Effects of Vasoactive Intestinal Peptide on Dura Mater Nitric Oxide Levels and Vessel-Contraction Responses in Sympathectomized Rats

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