Steroid receptors and hormones in relation to cell proliferation and apoptosis in poorly differentiated epithelial ovarian tumors

Lindgren, Peter; Bäckström, Torbjörn; Mählck, Carl-Gustav; Ridderheim, Mona; Cajander, Stefan

doi:10.3892/ijo.19.1.31

Cited by 26 publications

(28 citation statements)

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“…The percentage of tumours with ER expression (65% in our study) and PR is similar to the data published in the literature [22,23]. In our study 74% of tumour samples show positivity for Gn-RHR, which is in accordance with previous studies where the expression of Gn-RHR type I is around 80% in human ovarian epithelial tumours [24,25].…”

Section: Discussionsupporting

confidence: 95%

“…Recently, Arias-Pulido et al found, in a series of 89 patients with ovarian cancer including both initial and advanced disease, a superior clinical outcome for tumours with ER(-) PR(+) expression [30]. The rationale for a worse prognosis for ER(+) tumours could be related to the increase in proliferation, reduction of apoptosis and modulation of activity of EGFR and HER2/neu that oestrogen stimulus produces at the molecular level [22,31]. There is evidence that oestrogens can be produced intratumour after an in situ aromatisation and its mitogenic activity could be independent from circulating oestrogen [32].…”

Section: Discussionmentioning

confidence: 95%

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Gonadotropin and steroid receptors as prognostic factors in advanced ovarian cancer: a retrospective study

et al. 2009

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Section: Discussionsupporting

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Gonadotropin and steroid receptors as prognostic factors in advanced ovarian cancer: a retrospective study

et al. 2009

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“…Münstedt et al found that ER alone, in contrast to PR alone, had no value (9), but by examining the combined ER/ PR expression, they found that in particular ER-negative/PRpositive (>10%) tumors were associated with an increased overall survival for the patients (9). Another study also reported PR expression to be related to improved survival, results that were explained by the mechanisms of the progesterone-mediated inhibition of cell proliferation and induced apoptosis (20). Although one study failed to demonstrate any prognostic value of the ER receptor, it reported that patients with PR expression >10% survived longer than patients with PR expression levels <10% (5).…”

Section: Discussionmentioning

confidence: 85%

Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: From the ‘MALOVA’ Ovarian Cancer Study

Høgdall

Christensen²,

Høgdall³

et al. 2007

Oncol Rep

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Abstract. Estrogen and progesterone are important hormones secreted by the ovary acting through specific receptors. Tumor tissue expression profiles of these have demonstrated prognostic value in malignancies such as breast, uterine and prostate cancer. In this study, including tissue samples from 773 Danish patients with an ovarian tumor, we evaluated whether estrogen receptor (ER) and progesterone receptor (PR) expression correlated with clinico-pathological parameters, and a possible prognostic impact on ovarian cancer (OC) patients was investigated. Using tissue array and immunohistochemistry, we analyzed the ER and PR expression levels in tissues from 582 women with OC and 191 women with low malignancy potential (LMP) ovarian tumors. Our results demonstrated that ER was expressed in 30 of the 191 LMP tumors (16%) and in 207 of the 582 OC (36%). PR was expressed in 38 LMP tumors (20%) and in 115 OC (20%). For both tumor types an excess of positive tumors was found in the serous compared to the mucinous subtype (p≤0.00001). The frequency of ER expressionpositive OC increased with increasing FIGO stage (p=0.0003), and the frequency of PR-positive tumors increased with increasing histological grade (p=0.0006). In a Cox survival analysis, a tissue ER and PR expression 10% or higher was found to imply an independent significant advantageous course of patient disease-specific survival (ER: hazard ratio (HR), 0.80; 95% confidence interval (CI), 0.63-0.99; PR: HR, 0.69; 95% CI, 0.51-0.94) together with FIGO stage, residual tumor after primary surgery, age at diagnosis and other histological types vs. serous adenocarcinoma. The histological grade of tumor was found to have no independent prognostic value. The prognostic value of ER and PR was found additive with a HR for patients with high ER and PR expression of 0.48 (95% CI, 0.31-0.74) compared to patients with <10% expression for both receptors. In conclusion, our results predict that an elevated expression of ER and PR, alone and in combination, point to a favorable outcome for patients with OC.

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“…26) In addition, recent studies have demonstrated in situ production of progesterone in human common epithelial ovarian carcinoma. 27) Progesterone has also been considered to directly mediate decreased tumor growth 28) through inhibition of cell proliferation and induction of apoptosis. 29,30) The above findings suggest that DAX-1 may inhibit progesterone hormone production in the tumor tissue through repressing multiple biochemical steps in the steroidogenic cascade.…”

Section: Discussionmentioning

confidence: 99%

Nuclear receptor DAX‐1 in human common epithelial ovarian carcinoma: An independent prognostic factor of clinical outcome

Abd-Elaziz¹,

Akahira²,

Moriya³

et al. 2003

Cancer Science

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DAX-1 is a member of the nuclear receptor superfamily and is thought to be involved in the regulation of steroidogenesis. Its expression has been detected primarily in endocrine neoplasms such as adrenocortical as well as pituitary tumors in human, but its biological roles have not been examined well in sex steroiddependent neoplasms. The aim of this study is to detect the expression of DAX-1 in common epithelial ovarian carcinomas in order to evaluate its possible biological significance. DAX-1 immunoreactivity was examined using immunohistochemistry. The correlation between the status of DAX-1 immunoreactivity and clinicopathological parameters and disease-free survival of the patients in a series of 60 cases of common epithelial ovarian carcinoma was examined. The status of DAX-1 immunoreactivity was evaluated using H score. DAX-1 immunoreactivity was widely detected in the nuclei of common epithelial ovarian carcinoma cells. There was a significant positive correlation between DAX-1 immunoreactivity and clinical staging (P = = = =0.0241), tumor grade (P = = = =0.0115), the residual size of the tumor (P = = = =0.0014) and Ki-67 labeling index (P = = = = < < < <0.0001). In univariate survival analysis, a significant association was detected between DAX-1 immunoreactivity and shortened patient survival (P = = = =0.0157). ommon epithelial ovarian carcinomas are characterized by a broad spectrum of biological behavior ranging from tumors associated with excellent prognosis and response to therapy to those with poor prognosis and a high mortality rate. This marked variety is related to the fact that many patients are diagnosed at an advanced clinical stage.

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Steroid receptors and hormones in relation to cell proliferation and apoptosis in poorly differentiated epithelial ovarian tumors

Cited by 26 publications

References 0 publications

Gonadotropin and steroid receptors as prognostic factors in advanced ovarian cancer: a retrospective study

Gonadotropin and steroid receptors as prognostic factors in advanced ovarian cancer: a retrospective study

Prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: From the ‘MALOVA’ Ovarian Cancer Study

Nuclear receptor DAX‐1 in human common epithelial ovarian carcinoma: An independent prognostic factor of clinical outcome

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