Steroid receptor phylogeny and vertebrate origins

Baker, Michael E.

doi:10.1016/s0303-7207(97)00207-4

Cited by 111 publications

(100 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus far, adrenal and sex steroid receptors have been found only in vertebrates (Baker, 2002a(Baker, , 2003. This is consistent with PCR analysis of DNA from phylogenetically diverse animals (Escriva et al 1997) and sequence analysis steroid receptors (Baker, 1997(Baker, , 2001b(Baker, , 2003Escriva et al, 2000), both of which conclude that adrenal and sex steroid receptors arose at the beginning of the vertebrate line.…”

Section: Adrenal and Sex Steroid Receptors Are A Vertebrate Innovationsupporting

confidence: 78%

“…Our model suggests that modern neurosteroids were ligands for the ancestral ER and PR. Binding of these steroids to the ancestral ER would be consistent with the ancestral ER having an important role in the evolution of a more complex brain, which occurred in amphioxus and jawless fish (Baker, 1997(Baker, , 2001b. In fact, the previously discussed estrogenic actions of 5-Adiol may be a relic of its earlier activity in the brain, suggesting that other 5 steroids derived from DHEA, pregnenolone or 17 -hydroxyprenenolone may be discovered that bind vertebrate adrenal and sex steroid receptors.…”

Section: Clues For Understanding Adrenarche and Neurosteroid Action?supporting

confidence: 54%

“…Phylogenetic analysis of the adrenal and sex steroid receptors indicates that they arose by a series of gene duplications (Baker, 1997(Baker, , 2001b(Baker, , 2002bEscriva et al, 1997Escriva et al, , 2000Thornton, 2001). Analysis of the evolution of the ligand-binding domain indicates that the ER is the most ancient of the adrenal and sex steroid receptors (Baker, 2001b(Baker, , 2002bThornton 2001).…”

Section: Evolution Of Adrenal and Sex Steroid Receptors Through A Sermentioning

confidence: 99%

“…BLAST searches of the genome of Ciona intestinalis with these mammalian and fish sequences reveals that Ciona lacks genes coding for adrenal and sex steroid receptors and many of the key enzymes necessary for steroid synthesis (Dehal et al 2002;Baker 2003). This suggests that the ancestral steroid receptor arose in a cephalochordate such as amphioxus (Baker, 1997(Baker, , 2001b.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors

Baker

2004

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Abstract. Receptors for the adrenal and sex steroids arose by a series of gene duplications from an ancestral nuclear receptor in a primitive vertebrate, at least 540 million years ago. Sequence analysis indicates many steroidogenic and steroid-inactivating enzymes, including cytochrome P450s and hydroxysteroid dehydrogenases, arose at the same time. The estrogen receptor (ER) appears to be the ancestral steroid receptor. Initially, the redundant duplicated ER had a low specificity for its new ligand. This raises the question: "How was specificity for responses to different steroids regulated early in the evolution of steroid receptors?" Selective expression of these steroid-metabolizing enzymes provided specificity for different steroid responses in primitive vertebrates. 17 -hydroxysteroid dehydrogenase-type 1 (17 -HSD-type 1) and 17 -HSD-type 2, which preferentially catalyze the reduction and oxidation at C17 of androgens and estrogens, respectively, provide an example of this mechanism. Selective expression of either 17 -HSD-type 1 or 17 -HSD-type 2 can regulate synthesis or inactivation of androgens or estrogens in specific cells.Steroids also were important in the evolution of land animals, which began about 400 million years ago.Steroidogenic and steroid-inactivating enzymes were recruited to regulate steroid-mediated responses as organ function became more complex. For example, in the kidney 11 -HSD-type 2 prevents binding of glucocorticoids to the mineralocorticoid receptor, which is crucial for aldosterone-mediated regulation of electrolyte transport in the distal tubule. We propose that 5 steroids, such as dehydroepiandrosterone and its metabolites, were the ligands for the ancestral ER. Understanding the actions of 5 steroids in amphioxus and lamprey may shed light on adrenarche and neurosteroid actions in humans.

show abstract

Section: Adrenal and Sex Steroid Receptors Are A Vertebrate Innovationsupporting

confidence: 78%

Section: Clues For Understanding Adrenarche and Neurosteroid Action?supporting

confidence: 54%

Section: Evolution Of Adrenal and Sex Steroid Receptors Through A Sermentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors

Baker

2004

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

show abstract

“…Phylogenetic analysis of vertebrate steroid receptors shows that the ER is separate from the AR, PR, GR and MR [4,6,7,9], which correlates with their steroid specificity.…”

mentioning

confidence: 99%

3D model of amphioxus steroid receptor complexed with estradiol

Baker

Chang

2009

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Estrogen receptor‐ and aromatase‐deficient mice provide insight into the roles of estrogen within the ovary and uterus*

Rosenfeld

Roberts

Lubahn

2001

Molecular Reproduction Devel

View full text Add to dashboard Cite

Estrogen receptor (ER)- (alpha, beta, and both alpha and beta) and aromatase (Ar) knockout (KO) mice have been created to assess the biological effects of estrogens. This review article discusses the ovarian and uterine phenotypes of these mice. The data obtained have confirmed some older inferences about how the steroid acts, but have also revealed some unexpected aspects of estrogen action. Mol. Reprod. Dev. 59:336-346, 2001.

show abstract

Steroid receptor phylogeny and vertebrate origins

Cited by 111 publications

References 34 publications

Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors

Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors

3D model of amphioxus steroid receptor complexed with estradiol

Estrogen receptor‐ and aromatase‐deficient mice provide insight into the roles of estrogen within the ovary and uterus*

Contact Info

Product

Resources

About