Steroid hormone signaling is involved in the age-dependent behavioral response to sex pheromone in the adult male moth Agrotis ipsilon

Duportets, Line; Maria, Annick; Vitecek, Simon; Gadenne, Christophe; Debernard, Stéphane

doi:10.1016/j.ygcen.2013.02.024

Cited by 24 publications

(39 citation statements)

References 62 publications

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“…DA injected in the moth hemocoel has previously been shown to result in increased brain levels of DA (Linn et al, 1994). For 20E and CurB, 5-day-old males received an injection of 2 μl of a 10 −5 M solution as described previously (Duportets et al, 2013). Control experiments were performed by injection of 2 μl Ringer solution or ethanol solutions diluted as for DA and CurB solutions.…”

Section: Methodsmentioning

confidence: 99%

“…Also in arthropods, both hormones and neuromodulators are involved in behavioral plasticity by mediating structural and physiological changes (Walikonis et al, 1991; Linn et al, 1992; Sigg et al, 1997; Lehman et al, 2000; Jarriault et al, 2009). 20-hydroxyecdysone (20E), the major insect steroid hormone, is mainly known to modulate developmental processes, adult physiology and sexual behavior by interacting with a nuclear complex composed of the ecdysone receptor (EcR) and its partner ultraspiracle (USP) and thus eliciting genomic actions (Bigot et al, 2012; Fahrbach et al, 2012; Duportets et al, 2013). On the other hand biogenic amines such as dopamine (DA), octopamine, serotonin or tyramine are well described to orchestrate a broad range of physiological functions when binding with a wide panel of membrane-coupled receptors (Roeder, 2005; Lange, 2009; Duportets et al, 2010; Van Swinderen and Andretic, 2011; McQuillan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…This increase in pheromone response with age is paralleled with an increase in the sensitivity of neurons in the primary olfactory center, the antennal lobe (AL; Anton and Gadenne, 1999). Hormones such as juvenile hormone (JH) and 20E, as well as catecholamines such as octopamine have been shown to be involved either alone or in interaction in this behavioral and central nervous olfactory plasticity (Anton and Gadenne, 1999; Jarriault et al, 2009; Duportets et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

“…Concerning ecdysteroids, recent data show that 20E injection in immature males can increase both EcR and USP expression, concomitantly with the behavioral sensitivity of males for the sex pheromone (Duportets et al, 2013). On the other hand, injection of cucurbitacin B (CurB), an antagonist of 20E able to interact with the EcR/USP complex, inhibited the behavioral pheromone response in A. ipsilon (Duportets et al, 2013). Although another catecholamine, octopamine, was found to be necessary to elicit sexual attraction behavior in A. ipsilon (Jarriault et al, 2009), nothing is known concerning the role of DA.…”

Section: Introductionmentioning

confidence: 99%

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The GPCR membrane receptor, DopEcR, mediates the actions of both dopamine and ecdysone to control sex pheromone perception in an insect

Abrieux

Duportets

Debernard

et al. 2014

Front. Behav. Neurosci.

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Olfactory information mediating sexual behavior is crucial for reproduction in many animals, including insects. In male moths, the macroglomerular complex (MGC) of the primary olfactory center, the antennal lobe (AL) is specialized in the treatment of information on the female-emitted sex pheromone. Evidence is accumulating that modulation of behavioral pheromone responses occurs through neuronal plasticity via the action of hormones and/or catecholamines. We recently showed that a G-protein-coupled receptor (GPCR), AipsDopEcR, with its homologue known in Drosophila for its double affinity to the main insect steroid hormone 20-hydroxyecdysone (20E), and dopamine (DA), present in the ALs, is involved in the behavioral response to pheromone in the moth, Agrotis ipsilon. Here we tested the role of AipsDopEcR as compared to nuclear 20E receptors in central pheromone processing combining receptor inhibition with intracellular recordings of AL neurons. We show that the sensitivity of AL neurons for the pheromone in males decreases strongly after AipsDopEcR-dsRNA injection but also after inhibition of nuclear 20E receptors. Moreover we tested the involvement of 20E and DA in the receptor-mediated behavioral modulation in wind tunnel experiments, using ligand applications and receptor inhibition treatments. We show that both ligands are necessary and act on AipsDopEcR-mediated behavior. Altogether these results indicate that the GPCR membrane receptor, AipsDopEcR, controls sex pheromone perception through the action of both 20E and DA in the central nervous system, probably in concert with 20E action through nuclear receptors.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The GPCR membrane receptor, DopEcR, mediates the actions of both dopamine and ecdysone to control sex pheromone perception in an insect

Abrieux

Duportets

Debernard

et al. 2014

Front. Behav. Neurosci.

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“…An age-dependent response to a sexual pheromone is common in many arthropods (e.g. Klein et al 2012) and can be caused by a variety of factors like age-related variation in the pheromone emission and composition (Coppee et al 2011;Kuo et al 2012;Wang et al 2015) or hormone-triggered behavioural plasticity (Duportets et al 2013;Jarriault et al 2009). Mating of A. tumida follows a fixed order of behaviours which is often interrupted by aggressive females.…”

Section: Discussionmentioning

confidence: 99%

Age and aggregation trigger mating behaviour in the small hive beetle, Aethina tumida (Nitidulidae)

Mustafa

Spooner-Hart

Duncan

et al. 2015

Sci Nat

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This study aimed to investigate the poorly documented reproductive behaviour of the small hive beetle, Aethina tumida (Nitidulidae), a honey bee (Apis mellifera) parasite. We described the mating behaviour in detail and tested the hypothesis that beetle aggregation plays a vital role in mating in this species. Gender preference was examined in the context of age-dependency and possible chemical communication. Beetles started mating at a high frequency 18 days after emergence from the soil but only if they were aggregated (p < 0.001); mating was infrequent when beetles were paired. Males in aggregation also tried to copulate with males and only copulated more frequently with females at 18 days after emergence from soil (p < 0.001) in contrast to newly emerged, 7-day-old and 60-day-old beetles. Males and females spent more time in social contact with the opposite sex (p < 0.01) when they were 18 days old in contrast to 7-day-old beetles. Filter papers which had been in contact with 21-day-old beetles were highly attractive to similar-aged beetles of the opposite sex (p < 0.01). This suggests that chemical substances produced by the beetles themselves play a role in mating. Mating behaviour was characterised by a short pre-copulation courtship and female aggression towards other females and copulating couples. Both behaviours may be indicative of cryptic female choice. Delayed onset of reproductive behaviour is typical of many polygamous species, whilst the indispensability of aggregation for onset of sexual behaviour seems to be a feature unique to A. tumida. Both strategies support mass reproduction in this parasitic species, enabling A. tumida to overcome its honey bee host colony, and are probably triggered by chemotactic cues..

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Ecdysteroid signalling in insects—From biosynthesis to gene expression regulation

Yamanaka

2021

Advances in Insect Physiology

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Steroid hormone signaling is involved in the age-dependent behavioral response to sex pheromone in the adult male moth Agrotis ipsilon

Cited by 24 publications

References 62 publications

The GPCR membrane receptor, DopEcR, mediates the actions of both dopamine and ecdysone to control sex pheromone perception in an insect

The GPCR membrane receptor, DopEcR, mediates the actions of both dopamine and ecdysone to control sex pheromone perception in an insect

Age and aggregation trigger mating behaviour in the small hive beetle, Aethina tumida (Nitidulidae)

Ecdysteroid signalling in insects—From biosynthesis to gene expression regulation

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