Steroid Constituents from the Soft Coral <i>Sinularia nanolobata</i>

Abstract

Six steroids (1-6), including the two new compounds 3β,4α-dihydroxyergosta-5,24(28)-diene (1) and 24(S),28-epoxyergost-5-ene-3β,4α-diol (2), were isolated from the methanol extract of the Vietnamese soft coral Sinularia nanolobata. Their structures were elucidated by spectroscopic methods including one and two dimensional (1D-and 2D)

Cytotoxic Steroids from the Vietnamese Soft Coral <i>Sinularia leptoclados</i>

“…1) were isolated from a methanol extract of the soft coral S. leptoclados. The known compounds, 7-oxogorgosterol (3), 6) crassumsterol (4), 9) 7β-hydroxygorgosterol (5), 10) sarcophytosterol (6), 11) 3β-hydroxyergosta-5-ene-7-one (7), 12) ergost-5-en-3β,7β-diol (8), 13) ergost-5-en-3β,7α-diol (9), 14,15) ergosta-5,24(28)-diene-3β-ol (10), 16) 3β-hydroxyergost a-5,24(28)-diene-7-one (11), 17,18) ergosta-5,22,24(28)-trien-3β-ol (12), 19) 3β,7β-dihydroxyergosta-5,24(28)-diene (13), 20) 3β,7α-di hydroxyergosta-5,24(28)-diene (14), 20) and 3β,4α-dihydroxyergosta-5,24(28)-diene (15), 7) were identified by detailed analysis of their one and two dimensional (1-and 2D)-NMR and MS data as well as comparison of them with those reported in the literatures. Pos.…”

“…1,2) Sinularia soft corals are a rich source of steroids and terpenoids. [2][3][4][5] As a part of our ongoing investigations on cytotoxic steroids from Vietnamese Sinularia soft corals, [6][7][8] this paper addressed the isolation, structure elucidation, and cytotoxic evaluation of fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), from the soft coral S. leptoclados.…”

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn 2013‐2017

“…Hợp chất 105 thể hiện hoạt tính gây độc tế bào ung thư ở mức độ trung bình trên dòng HL-60 (IC 50 = 33,53±4,25 M) và yếu trên dòng HepG2 (IC 50 = 64,35±7,00 M) và SW480 (IC 50 = 71,02±4,00 M). [35] Hợp chất mới crassumsterol (107) cùng với (22R,23R,24R)-5 ,8epidioxy-22,23-methylene-24-methylcholest-6-en-3 -ol (108), ergosterol peroxide (109) và 3hydroxyandrost-5-en-17-one (110) được phân lập từ loài san hô mềm Lobophytum crassum. Các hợp chất, 108 và 109 thể hiện hoạt tính ức chế sự hoạt hóa NF-B với giá trị IC 50 tương ứng 3,90 và 7,05 µM và ức chế sự biểu hiện mRNA của COX-2 và iNOS.…”

Structure Elucidation of Four Steroids From the Soft Coral Sinularia Nanolobata

“…The Sinularia soft corals are a rich source of hydroxylated steroids having cytotoxic effects [2 -8]. Within the frame of our recent investigations on chemical constituents and biological activities of Vietnamese Sinularia soft corals [9,10], we have recently reported six steroids from the soft coral Sinularia nanolobata and evaluation of their cytotoxic activity [11]. The current paper deals with detailed structure elucidation of four steroids from this species.…”