Sternal Marrow in Banti’s Syndrome and Other Splenomegalic States: The Effect of Splenectomy

Granulocyte changes in infectious mononucleosis

“…Secondly, granulocyte precursors in the bone marrow are probably not significantly reduced. Most authors describe a leucoblastic hyperplasia with a shift to the left (Limarzi, Paul, and Poncher, 1946;Custer and Smith, 1948;Campbell, 1948) and the five bone marrow biopsies examined in the present investigation showed no features suggesting depressed granulocytopoiesis or defective release of cells. Considerations of this kind raise the possibility of excessive peripheral destruction, brought about either by the exaggerated activity of the normal destructive processes or by abnormal immune mechanisms.…”

The Anemia of Liver Disease: Observations on Its Mechanism 1

“…The hypothesis that this anemia is metabolically similar to pernicious anemia and that it arises from defective storage of the subsequently identified Vitamin Bl2 (1)(2)(3) has been generally rejected for several reasons, namely: The morphologic dissimilarities of the two types of anemia (4,5); the failure of typical cases to respond to preparations containing Vitamin B,2 (6); the demonstration of anti-pernicious anemia activity in the liver of cirrhotic patients with macrocytic anemia (7); and the inability of liver extract to prevent anemia during experimental liver injury (8). More recently it has been suggested that another, unrelated metabolic defect exists (6), possibly exaggerated in some cases 1 This investigation was supported in part by research by hemodilution (9).…”

Hematologic Observations in Patients With Chronic Hepatic Insufficiency

“…In spite of these inconsistencies, the prevailing hypothesis still classes the macrocytic anemia of chronic liver disease with the erythrocyte maturation factor deficiency anemias. This is true even though the only report on bone marrow morphology 1 Presented in part before the American Society for Clinical Investigation, Atlantic City, N. J., May 3, 1948. 2This work has been supported by grants from the Robert Gould Research Foundation, Merck failed to demonstrate megaloblastic maturation arrest (7). The data presented in this paper stress the normoblastic rather than megaloblastic type of bone marrow morphology found in the majority of patients with cirrhosis and macrocytic anemia.…”