Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease

Landeck, Natalie; Mazza, Melissa Conti; Duffy, Megan F.; Bishop, Christopher; Sortwell, Caryl E.; Cookson, Mark

doi:10.3791/62128

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Tissue/cell-specific Mutation For Dissecting Host-microbe In...1

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2024

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“…In situ injection involves directly injecting gene delivery system into the target tissue of interest, such as brain ( Landeck et al, 2021 ), muscles ( Kenjo et al, 2021 ), and myocardium ( Gabisonia et al, 2019 ). This method restricts dissemination of the vehicle to the local area, minimizing its impact on other tissues and organs.…”

Section: Tissue/cell-specific Mutation For Dissecting Host-microbe In...mentioning

confidence: 99%

Recent advances in host-focused molecular tools for investigating host-gut microbiome interactions

Wang,

Gong,

Xiao

et al. 2024

Front. Microbiol.

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Microbial communities in the human gut play a significant role in regulating host gene expression, influencing a variety of biological processes. To understand the molecular mechanisms underlying host-microbe interactions, tools that can dissect signaling networks are required. In this review, we discuss recent advances in molecular tools used to study this interplay, with a focus on those that explore how the microbiome regulates host gene expression. These tools include CRISPR-based whole-body genetic tools for deciphering host-specific genes involved in the interaction process, Cre-loxP based tissue/cell-specific gene editing approaches, and in vitro models of host-derived organoids. Overall, the application of these molecular tools is revolutionizing our understanding of how host-microbiome interactions contribute to health and disease, paving the way for improved therapies and interventions that target microbial influences on the host.

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Section: Tissue/cell-specific Mutation For Dissecting Host-microbe In...mentioning

confidence: 99%

Recent advances in host-focused molecular tools for investigating host-gut microbiome interactions

Wang,

Gong,

Xiao

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease

Cited by 1 publication

References 27 publications

Recent advances in host-focused molecular tools for investigating host-gut microbiome interactions

Recent advances in host-focused molecular tools for investigating host-gut microbiome interactions

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