Stereotactic radiosurgery in patients with multiple intracranial meningiomas

Samblás, J.; Guerra, J.L. Lopez; Bustos, J.C.; Gutierrez, JP; Peraza, Carmen; Azinovic, I.; Sallabanda, Kita

doi:10.1016/j.rpor.2013.03.560

Cited by 3 publications

(6 citation statements)

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“…Our results are in accordance with other reports in the literature, which show that the mean age of presentation with multiple meningiomas is in the 6th decade of life and is the same as for patients with single tumors. 6,8,28,29 Multiple meningiomas are more common in women, and the female predilection is significantly higher at 3.5:1 than that for single meningiomas. 6,8,29 In our series, the higher female ratio was also observed in the radiation-induced cases, although the sex difference was less distinct and similar to that for radiation-induced single meningiomas.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, in a study specific to multiple meningiomas treated with SRS, the complication rate was 10%. 28 In our opinion, patient-and tumor-specific factors should be considered, and there are several advantages to an expectant management approach for radiologically stable incidental meningiomas.…”

Section: Management Of Multiple Meningiomasmentioning

confidence: 98%

“…Our longterm results were very good and comparable with those reported in similar studies. 28 Radiosurgery seems to be an attractive therapeutic option for multiple meningiomas up to 3 cm in diameter, but more research is needed to establish its effectiveness and safety for this disease.…”

Section: Management Of Multiple Meningiomasmentioning

confidence: 99%

“…However, to our knowledge, this study is the largest of its type, allowing for more powerful statistical analysis and generalizable results, and providing a comprehensive management strategy with details on epidemiology, decision making, and treatment options. 8,16,28,41…”

Section: Limitations Of the Studymentioning

confidence: 99%

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Management of multiple meningiomas

Tsermoulas¹,

Turel²,

Wilcox³

et al. 2018

Journal of Neurosurgery

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OBJECTIVE Multiple meningiomas account for 1%-10% of meningiomas. This study describes epidemiological aspects of the disease and its management, which is more challenging than for single tumors. METHODS A consecutive series of adult patients with ≥ 2 spatially separated meningiomas was reviewed. Patients with neurofibromatosis Type 2 were excluded. The authors collected clinical, imaging, histological, and treatment data to obtain information on epidemiology, management options, and outcomes of active treatment and surveillance. RESULTS A total of 133 consecutive patients were included over 25 years, with a total of 395 synchronous and 53 metachronous meningiomas, and a median of 2 tumors per patient. One hundred six patients had sporadic disease, 26 had radiation-induced disease, and 1 had familial meningiomatosis. At presentation, half of the patients were asymptomatic. In terms of their maximum cross-sectional diameter, the tumors were small (≤ 2 cm) in 67% and large (> 4 cm) in 11% of the meningiomas. Fifty-four patients had upfront treatment, and 31 had delayed treatment after an observation period (mean 4 years). One in 4 patients had ≥ 2 meningiomas treated. Overall, 64% of patients had treatment for 142 tumors-67 with surgery and 18 with radiotherapy alone. The mean follow-up was 7 years, with 13% of treated patients receiving salvage therapy. Approximately 1 in 4 patients who underwent surgery had ≥ 1 WHO Grade II or III meningioma. Meningiomas of different histological subtypes and grades in the same patient were not uncommon. CONCLUSIONS Multiple meningiomas are often asymptomatic, probably because the majority are small and a significant proportion are induced by radiation. Approximately two-thirds of patients with multiple meningiomas require therapy, but only one-third of all meningiomas need active treatment. The authors recommend surveillance for stable and asymptomatic meningiomas and therapy for those that are symptomatic or growing.

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Section: Discussionmentioning

confidence: 99%

Section: Management Of Multiple Meningiomasmentioning

confidence: 98%

Section: Management Of Multiple Meningiomasmentioning

confidence: 99%

Section: Limitations Of the Studymentioning

confidence: 99%

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Management of multiple meningiomas

Tsermoulas¹,

Turel²,

Wilcox³

et al. 2018

Journal of Neurosurgery

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“…Through a division of the lesion into three side-by-side dose matrices and applying a marginal and maximal SRS dose of 12 Gy and 24 Gy, respectively, the patient has experienced tumor regression and has been recurrence-free over a 5-year period. Reporting on a cohort of 73 patients with multiple SMs (primary or recurrent, 221 total lesions) managed with linear accelerator-based SRS, Samblas and colleagues have demonstrated a 90% tumor control rate over a median follow-up of 5.3 years [ 46 ]. While these advances are encouraging, they apply to SMs and represent individual studies only.…”

Section: Selecting the Optimal Management Modalitymentioning

confidence: 99%

The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions

Mansouri

Badhiwala

Mansouri

et al. 2014

BioMed Research International

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Meningiomas are among the most common primary adult brain tumors, which arise either spontaneously or secondary to environmental factors such as ionizing radiation. The latter are referred to as radiation-induced meningiomas (RIMs) which, while much less common than their spontaneous counterparts, are challenging from a management point of view. Similar to spontaneous meningiomas, the optimal management of RIMs is complete surgical resection. However, given their high grade, multiplicity, tendency to invade bone and venous sinuses, and high recurrence rate, this cannot always be accomplished safely. Therefore, other therapeutic modalities, such as stereotactic radiosurgery, have emerged. In the current review, we provide an overview of the historical outcomes achieved for RIMs through radiosurgery and microsurgical resection. Furthermore, we provide a discussion of clinical and radiological parameters that affect the decision-making process with regard to the management of RIMs. We also provide an outline of recent changes in our understanding of RIMs, based on molecular and genetic markers, and how these will change our management perspective. We conclude the review by summarizing some of the current obstacles in the management of RIMs with SRS and how current and future research can address these challenges.

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Clinical and Surgical Aspects of Meningothelial Meningioma in Practice and the Implications of Brain-It Summer School

Săceleanu

Țeposu

Joarză

et al. 2021

Acta Medica Transilvanica

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Mrs. F.M, a 77-year-old woman with prior diagnosis of Alzheimer disease, temporal lobe epilepsy, conversion disorder and essential familial hypercholesterolemia, presented for 2 months diffuse headache and vertigo, and in the past week, left brachial monoparesis and episodic amnesia become apparent, with progressive worsening and no improvement with medication therapy. The CT/MRI findings constituted a real challenge even for experienced practitioners. This article is hereby designed to meet the needs and necessities of young doctors within BrainIT international summer school.

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Stereotactic radiosurgery in patients with multiple intracranial meningiomas

Cited by 3 publications

References 0 publications

Management of multiple meningiomas

Management of multiple meningiomas

The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions

Clinical and Surgical Aspects of Meningothelial Meningioma in Practice and the Implications of Brain-It Summer School

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