Stereotactic Radiation Therapy of Intracranial Lesions Methodologic Aspects

Greitz, T.; Lax, Ingmar; Bergström, Mats; Arndt, J; Berggren, Britt-Marie; Blomgren, Henric; Boëthius, J.; Lindqvist, M.; Ribbe, T.; Steiner, Ladislau

doi:10.3109/02841868609136383

Cited by 43 publications

(12 citation statements)

References 17 publications

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“…This method gives a target dose uniform to within 10% but a relatively slow fall‐off outside the target volume. Greitz et al 16 reported that with an isocentric six‐beam technique, the distance between the 95% and 65% isodoses was 2 to 5 mm. Our method with the static beam is superior and more reliable than the moving beam therapy from the dosimetric perspective of sparing critical organs and calculating the target dose.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic radiotherapy for locally recurrent nasopharyngeal carcinoma

et al. 1999

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Objective: To determine the efficacy of stereotactic radiotherapy (SRT) in the treatment of recurrent nasopharyngeal carcinoma. Study Design: A retrospective review of the outcome of SRT for patients with recurrent nasopharyngeal carcinomas following definitive conventional radiation therapy. Methods: Five patients were treated with daily static multiportal irradiation. Two Gy was administered with eight isocentric portals in a single plane 5 days a week, and the plane was changed for every 20 to 30 Gy. Of these patients, three had poorly differentiated squamous cell carcinoma. Tumor sizes ranged from 1 to 15 cm3, with a median size 3.2 cm3. Median follow‐up time from SRT was 34 months (range, 4–61 mo). Results: Four of five recurrent tumors responded well and achieved complete regression. Three patients have survived without evidence of local recurrence with a median follow‐up time of 34 months. Marginal recurrence was observed at the posterosuperior wall in a patient with adenoid cystic carcinoma at 30 months after SRT. One patient who received SRT after the two complete courses of radiation therapy died 6 months after SRT as a result of rupture of a branch of the left carotid artery, but autopsy revealed no local residual tumor. Conclusions: Stereotactic radiotherapy with isocentric multiportals in one plane, which is changed at every 20 to 30 Gy, can provide local control with acceptable toxicity in patients with recurrent nasopharyngeal carcinoma, but increased clinical experience and longer follow‐up will be necessary to evaluate the overall role of this technique in nasopharyngeal carcinoma.

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Section: Discussionmentioning

confidence: 99%

Stereotactic radiotherapy for locally recurrent nasopharyngeal carcinoma

et al. 1999

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“…Therefore, the first limitation of radiosurgery is the irradiated volume of healthy tissue. This becomes a critical point when treating AVMs >25-30 mm in diameter [17][18][19] or when a safety margin needs to be added to the size of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Fractionated brain stereotactic irradiation using a relocatable frame. technique and preliminary results

Delannes¹,

Daly-Schveitzer²,

Sabatier³

et al. 1993

International Journal of Radiation Oncology*Biology*Physics

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“…The Department of Neuro radiology at the Karolinska Hospital has played an important role in developing applications of the stereotactic technique in combination with the standard equipment used in diagnostic radiology (9,10,45,67). Previously, stereotactic localization was done with rather primitive equipment.…”

Section: Methodsmentioning

confidence: 99%