Stereotactic heavy-ion Bragg peak radiosurgery for intra-cranial vascular disorders: method for treatment of deep arteriovenous malformations

Clinical trials using accelerated heavy charged-particle beams for treating cancer and other diseases have been performed for nearly four decades. Recently there have been worldwide efforts to construct hospital-based medically dedicated proton or light-ion accelerator facilities. To make such accelerated heavy charged-particle beams clinically useful, specialized instruments must be developed to modify the physical characteristics of the particle beams in order to optimize their biological and clinical effects. This article reviews the beam modifying devices and associated dosimetric equipment developed specifically for controlling and monitoring the clinical beams.

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“…83 Mter 1987, the LBL helium-ion programs have been continued at the Bevatron. 84 More than 2200 patients have been treated using helium ions.…”

Section: Ibl On-going Proton and Helium-ion Trialsmentioning

confidence: 99%

Instrumentation for treatment of cancer using proton and light-ion beams

Chu

Ludewigt

Renner

1993

Review of Scientific Instruments

283

186

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“…Leksell, in Sweden, reported on the use of the Uppsala research beam for intracranial SRS in the late 1950s and Kjellberg used the Harvard Cyclotron Laboratory research machine for similar purposes in the 1960s, as did Fabrikant on the West coast. 8,19,25,52 The Harvard experience continued for several years and that group accumulated a large patient database. Some of these early attempts made in the era before modern 3D imaging were limited to treatment of intracranial structures that could be well localized without benefit of such imaging; pituitary adenomas were notable examples.…”

Section: Historical Perspectives Of Stereotactic Radiationmentioning

confidence: 99%

Surgery and radiotherapy: complementary tools in the management of benign intracranial tumors

Johnson

Loredo

Slater

2008

FOC

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✓ Historically, radiation therapy has been used extensively in the treatment of malignant and aggressive intracranial tumors, and the importance of its role has been repeatedly verified by prolonged patient survival rates and increased tumor control. As more modern capabilities are employed in surgery and radiotherapy, attention is being directed to the utility of radiation as either primary or secondary treatment of benign tumors. Specifically, primary treatment encompasses irradiation of small benign tumors without biopsy confirmation of tumor type; secondary treatment involves postoperative radiation therapy, with the possibility that less-aggressive tumor resection may be performed in areas that have a higher probability of resultant neurological deficit. Current literature suggests that this is not only a possible treatment strategy, but that it may be superior to more radical resection in some cases, for example, in vestibular schwannomas and meningiomas. This article provides an overview of factors to consider in the use of radiation therapy and reviews the relationships between radiation and surgery, notably the unique complementary role each plays in the treatment of benign intracranial tumors.

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“…There has bee11 a recent surge in interest in stereotactic radiosurgery of intracranial lesions, such as arteriovenous malformations (AVMs), tumors and isolated metastases [3,4,6,7,9,11,12,13]. Much experience has been gained at a number of medical centers around the world in the past three decades [1,4,6,8,12,13].…”

Section: In:troductionmentioning

confidence: 99%

“…Much experience has been gained at a number of medical centers around the world in the past three decades [1,4,6,8,12,13]. The successful treatment of tumors and AVMs that were surgically-inaccessible has spawned the dissemination of stereotactic radiosurgical techniques at a number of different institutions.…”

Section: In:troductionmentioning

confidence: 99%