Comparison of different radiation types and irradiation geometries in stereotactic radiosurgery

Phillips, Mark H.; Frankel, Kenneth A.; Lyman, John; Fabrikant, Jacob I.; Levy, Richard P.

doi:10.1016/0360-3016(90)90286-s

Cited by 78 publications

(33 citation statements)

References 12 publications

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“…Such a difference is more relevant under the 60% dose level regardless of the target features [14]. Moreover, the larger the target volume the greater the difference [12,14,15], which peaks for regular shaped targets larger than 24-26 cc, even though it can be relevant even for smaller and irregular targets (about 6 cc) [14,15].…”

Section: Dosimetrical Featuresmentioning

confidence: 97%

“…The stereotactic delivering modalities and techniques have been compared in several plan comparison studies [12][13][14][15]. The corresponding efficacy has been investigated also on the basis of the normal tissue complication probability (NTCP) and tumour control probability (TCP) models in the attempt to set the results also on a biological basis [14,16].…”

Section: Dosimetrical Featuresmentioning

confidence: 99%

“…In general, the differences among photon-based techniques (GK, multi-non-coplanar arcs or shaped beams linac treatment) are negligible [12][13][14][15]. Conversely, the modality (photons or protons) can be what is more important.…”

Section: Dosimetrical Featuresmentioning

confidence: 99%

“…Based on the normal brain dose, the dosimetrical advantage of charged particles relative to photons is evident in all types of targets [12,14,15]. Such a difference is more relevant under the 60% dose level regardless of the target features [14].…”

Section: Dosimetrical Featuresmentioning

confidence: 99%

See 3 more Smart Citations

Radiosurgery and Hypofractionated Stereotactic Irradiation with Photons or Protons for Tumours of the Skull Base

Amelio¹,

Cianchetti²,

Rombi³

et al. 2013

Cancer Treatment - Conventional and Innovative Approaches

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Section: Dosimetrical Featuresmentioning

confidence: 97%

Section: Dosimetrical Featuresmentioning

confidence: 99%

Section: Dosimetrical Featuresmentioning

confidence: 99%

Section: Dosimetrical Featuresmentioning

confidence: 99%

See 2 more Smart Citations

Radiosurgery and Hypofractionated Stereotactic Irradiation with Photons or Protons for Tumours of the Skull Base

Amelio¹,

Cianchetti²,

Rombi³

et al. 2013

Cancer Treatment - Conventional and Innovative Approaches

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“…At the University of California at Berkeley -Lawrence Berkeley Laboratory (UCB-LBL) we have. developed stereotactic heavy-charged-particle Bragg peak radiosurgery for treatment of symptomatic surgicallyinaccessible intracranial arteriovenous malformations (AVMs) [1][2][3][4][5][6][7][8][9][10]. Narrow beams of accelerated helium ions are directed stereotactically to defined intracranial targets.…”

Section: Introductionmentioning

confidence: 99%

Heavy-Charged-Particle Radiosurgery for Intracranial Arteriovenous Malformations

Fabrikant

Levy²,

Steinberg³

et al. 1991

Stereotact Funct Neurosurg

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We have treated over 400 patients with symptomatic inoperable intracranial arteriovenous malformations (AVMs) with stereotactic heavy-charged-particle Bragg peak radiosurgery at the University of California at Berkeley in a collaborative program with Stanford University Medical Center and the University of California Medical Center, San Francisco. A long-term dose-searching clinical trial protocol has been developed and we have followed more than 250 patients for more than 2 years. Initially, radiation doses ranged from 45 to 35 GyE, and now doses of 25, 20, 15 and, under special circumstances, 10 GyE, depending on a number of factors, are being evaluated. The characteristics of charged-particle beams provide a relatively homogeneous dose distribution with the 90% isodose contour to the periphery of the lesion. When the entire arterial phase of the AVM core is included in the treatment field, the rates for complete obliteration 3 years after treatment are: 90–95% for volumes ≤4 cm³; 90–95% for volumes > 4 and ≤14 cm³; and 60–70% for volumes > 14 cm³. The total obliteration rate for all volumes up to 70 cm³ is approximately 80–85%. For complete radiation-induced obliteration there is a relationship of dose and volume primarily, and location secondarily. Results on relationships between dose, AVM obliteration, and complications and sequelae of the radiosurgical procedure are presented and discussed.

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Dosimetry and characterization of a 25‐MeV proton beam line for preclinical radiobiology research

et al. 2019

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Purpose With the increase in proton therapy centers, there is a growing need to make progress in preclinical proton radiation biology to give accessible data to medical physicists and practicing radiation oncologists. Methods A cyclotron usually producing radioisotopes with a proton beam at an energy of about 25 MeV after acceleration, was used for radiobiology studies. Depleted silicon surface barrier detectors were used for the beam energy measurement. A complementary metal oxide semiconductor (CMOS) sensor and a plastic scintillator detector were used for fluence measurement, and compared to Geant4 and an in‐house analytical dose modeling developed for this purpose. Also, from the energy measurement of each attenuated beam, the dose‐averaged linear energy transfer (LETd) was calculated with Geant4. Results The measured proton beam energy was 24.85 ± 0.14 MeV with an energy straggling of 127 ± 22 keV before scattering and extraction in air. The measured flatness was within ± 2.1% over 9 mm in diameter. A wide range of LETd is achievable: constant between the entrance and the exit of the cancer cell sample ranging from 2.2 to 8 keV/μm, beyond 20 keV/μm, and an average of 2–5 keV/μm in a scattering spread‐out Bragg peak calculated for an example of a 6‐mm‐thick xenograft tumor. Conclusion The dosimetry and the characterization of a 25‐MeV proton beam line for preclinical radiobiology research was performed by measurements and modeling, demonstrating the feasibility of delivering a proton beam for preclinical in vivo and in vitro studies with LETd of clinical interest.

show abstract

Comparison of different radiation types and irradiation geometries in stereotactic radiosurgery

Cited by 78 publications

References 12 publications

Radiosurgery and Hypofractionated Stereotactic Irradiation with Photons or Protons for Tumours of the Skull Base

Radiosurgery and Hypofractionated Stereotactic Irradiation with Photons or Protons for Tumours of the Skull Base

Heavy-Charged-Particle Radiosurgery for Intracranial Arteriovenous Malformations

Dosimetry and characterization of a 25‐MeV proton beam line for preclinical radiobiology research

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