Stereotactic body radiotherapy for low-risk prostate cancer: Five-year outcomes.

Abstract

Purpose: Hypofractionated, stereotactic body radiotherapy (SBRT) is an emerging treatment approach for prostate cancer. We present the outcomes for low-risk prostate cancer patients with a median follow-up of 5 years after SBRT. Results: At a median follow-up of 5 years, the biochemical progression-free survival was 93% (95% CI = 84.7% to 100%). Acute side effects resolved within 1-3 months of treatment completion. There were no grade 4 toxicities. No late grade 3 rectal toxicity occurred, and only one late grade 3 genitourinary toxicity occurred following repeated urologic instrumentation. Conclusion: Five-year results of SBRT for localized prostate cancer demonstrate the efficacy and safety of shorter courses of high dose per fraction radiation delivered with SBRT technique. Ongoing clinical trials are underway to further explore this treatment approach. Method and

Image-guided hypofractionated proton beam therapy for low-risk prostate cancer: Analysis of quality of life and toxicity, PCG GU 002

“…3,[20][21][22][23][24][25]27,28 Similarly, no AEs of grade 3 or higher were found in our study. Overall EPIC bowel scores were high during follow-up.…”

“…3,[20][21][22]24,30 In our present study, AUA scores and EPIC urinary scores had no significant change over time. Most symptoms were related to weak urinary stream that improved with medications, as reflected by an almost flat AUA score over time.…”

“…18 Clinical results for hypofractionated photon prostate cancer treatments have also been favorable. 3,[19][20][21][22][23][24][25][26][27][28][29][30][31] Many different fractionations, from 6.75 Gy in 5 treatments to 10 Gy in 5 treatments, have been used. Our design was based on data published with high-dose-rate brachytherapy for prostate cancer and the published normal tissue ˛/ř atio.…”

Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams

“…However, for a hypofractionated regimen with a dose per fraction of 7 Gy [21] and the same a/b values, the maximum modeled RBE value at the distal edge was <1.2. Consequently, the model predicted that a dose per fraction of 7 Gy could limit biological dose elevation at the beam distal edge to 10%, compared to 20% for the standard fractionation scheme.…”

Retrospective Analysis Of Patients And Treatment Characteristics: Istanbul Cyberknife Coalition Data

“…Rarely, SBRT of liver, pancreas and prostate cancer are also applicable [31][32][33][34][35]. A prospective study about prostate cancer treatment gave good local control and low toxicity rates after five fractions SBRT [35].…”