Stereospecificity of ginsenoside Rg2 epimers in the protective response against UV-B radiation-induced oxidative stress in human epidermal keratinocytes

Kang, Hyunji; Huang, Yuhua; Lim, Hye‐Won; Shin, Dae-Hyun; Jang, Kyounghee; Lee, Yoonjin; Kim, Kyunghoon; Lim, Chang‐Jin

doi:10.1016/j.jphotobiol.2016.10.034

Cited by 25 publications

(17 citation statements)

References 35 publications

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“…These results suggested that BDB has a protective effect on human keratinocytes against UVB radiation. UVB light stimulates the production of ROS to induce oxidative stress [ 21 , 22 ]. In our previous time-course experiment, we found that the maximal ROS levels induced by UVB exposure appeared at 24 h [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

The Red Algae Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Human Keratinocytes on Oxidative Stress-Related Molecules and Pathways Activated by UVB Irradiation

et al. 2017

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Skin exposure to ultraviolet B (UVB) irradiation leads to the generation of reactive oxygen species (ROS). Excessive ROS cause aging of the skin via basement membrane/extracellular matrix degradation by matrix metalloproteinases (MMPs). We recently demonstrated that 3-bromo-4,5-dihydroxybenzaldehyde (BDB), a natural compound of red algae, had a photo-protective effect against UVB-induced oxidative stress in human keratinocytes. The present study focused on the effect of BDB on UVB-irradiated photo-aging in HaCaT keratinocytes and the underlying mechanism. BDB significantly impeded MMP-1 activation and expression, and abrogated the activation of mitogen-activated protein kinases and intracellular Ca2+ level in UVB-irradiated HaCaT cells. Moreover, BDB decreased the expression levels of c-Fos and phospho-c-Jun and the binding of activator protein-1 to the MMP-1 promoter induced by UVB irradiation. These results offer evidence that BDB is potentially useful for the prevention of UVB-irradiated skin damage.

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Section: Resultsmentioning

confidence: 99%

The Red Algae Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Human Keratinocytes on Oxidative Stress-Related Molecules and Pathways Activated by UVB Irradiation

et al. 2017

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“…Ginsenoside Rg2 could reduce oxidative stress injury and improve myocardial ischemia and hypoxia by regulating the activities of serum creatine kinase (CK), lactate dehydrogenase (LDH), lipid peroxides (LPOs), superoxide dismutase (SOD), and glutathione peroxidase (GPX) in rats [ 51 ]. Ginsenoside Rg2 was also shown to reduce oxidative stress in human epidermal keratinocytes [ 52 ].…”

Section: Application Of Antioxidant Natural Drugs For Cardiovasculmentioning

confidence: 99%

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Chang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) refers to the physiological imbalance between oxidative and antioxidative processes leading to increased oxidation, which then results in the inflammatory infiltration of neutrophils, increased protease secretion, and the production of a large number of oxidative intermediates. Oxidative stress is considered an important factor in the pathogenesis of cardiovascular disease (CVD). At present, active components of Chinese herbal medicines (CHMs) have been widely used for the treatment of CVD, including coronary heart disease and hypertension. Since the discovery of artemisinin for the treatment of malaria by Nobel laureate Youyou Tu, the therapeutic effects of active components of CHM on various diseases have been widely investigated by the medical community. It has been found that various active CHM components can regulate oxidative stress and the circulatory system, including ginsenoside, astragaloside, and resveratrol. This paper reviews advances in the use of active CHM components that modulate oxidative stress, suggesting potential drugs for the treatment of various CVDs.

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“…It also protected dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced toxicity and brain damage from sepsis by inhibiting cerebral inflammation and neuron loss in the hippocampus [80][81][82][83]. Ginsenoside Rg 2 had a protective effect against glutamate-induced neuronal injury and the formation of Ab in PC12 cells, protected memory functions against impairment induced by cerebral ischemia-reperfusion and the neuronal apoptosis, and attenuated the UV-B-induced promatrix metalloproteinase-2 gelatinolytic activity and protein level [84][85][86]. Ginsenoside Rh 1 inhibited the infiltration of inflammatory cells into skin lesions and MMP-1 transcriptional activity and decreased the concentrations of IgE and IL-6 in serum, expression and stability of Ap-1 dimer, c-Fos, and c-Jun by inhibiting the activation of JNK and ERK 1/2 in HepG2 cells [87,88].…”

Section: Improved Health Functionality Through Bioconversionmentioning

confidence: 99%

Bioconversion, health benefits, and application of ginseng and red ginseng in dairy products

Jung

Lee

Paik

2017

Food Sci Biotechnol

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Ginseng and red ginseng are popular as functional foods in Asian countries such as Korea, Japan, and China. They possess various pharmacologic effects, including antioxidant, anti-inflammatory, anti-cancer, anti-obesity, and anti-viral activities. Ginsenosides are a class of pharmacologically active components in ginseng and red ginseng. Major ginsenosides are converted to minor ginsenosides, which have better bioavailability and cellular uptake, by microorganisms and enzymes. Studies have shown that ginseng and red ginseng can affect the physicochemical and sensory properties, ginsenosides content, and functional properties of dairy products. In addition, lactic acid bacteria in dairy products can convert into minor ginsenosides and ginseng and red ginseng improve functionality of products. This review will discuss the characteristics of ginseng and red ginseng, and their bioconversion, functionality, and application in dairy products.

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Stereospecificity of ginsenoside Rg2 epimers in the protective response against UV-B radiation-induced oxidative stress in human epidermal keratinocytes

Cited by 25 publications

References 35 publications

The Red Algae Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Human Keratinocytes on Oxidative Stress-Related Molecules and Pathways Activated by UVB Irradiation

The Red Algae Compound 3-Bromo-4,5-dihydroxybenzaldehyde Protects Human Keratinocytes on Oxidative Stress-Related Molecules and Pathways Activated by UVB Irradiation

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Bioconversion, health benefits, and application of ginseng and red ginseng in dairy products

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