Stereoselective One-Pot, Three-Component Synthesis of 4-Aryltetrahydropyran via Prins−Friedel−Crafts Reaction

Abstract

A diastereoselective one-pot, three-component Prins-Friedel-Crafts reaction was developed for the synthesis of 4-aryltetrahydropyran derivatives from the reaction of carbonyl compounds with homoallylic alcohol in the presence of arene promoted by boron trifluoride etherate.

An Efficient Method for the Synthesis of 10‐Aminoartemisinin Derivative

“…In our recent work we have generated oxocarbenium ion and then trapped by nucleophiles such as arene [11]. Our initial attempt to generate oxocarbenium ion from DHA using BF 3 ·Et 2 O and then trap by nucleophiles such as acetonitrile and arene failed (Scheme ).…”

Multicomponent Reactions for the Synthesis of Heterocycles

“…Eleven examples were investigated under mild conditions; atom efficiency and good substrate scope was seen to show moderate to good yields. [65] Condensation of 3-aminocoumarin with 4-nitrobenzaldehyde afforded 2-azadienes, which were then reacted with various electron-rich alkenes (10 examples [68] Aromatic aldehydes containing electron-withdrawing groups and simple benzaldehyde afforded better yields relative to electron-donating groups. Saturated aliphatic aldehydes are found to be better substrates Scheme than the conjugated aliphatic aldehydes.…”

One‐Pot Synthesis of 2′‐Aminobenzothiazolo‐Arylmethyl‐2‐Naphthols Catalyzed by NBS under Solvent‐Free Conditions

“…Green chemistry approaches are significant due to the reduction in byproducts, reduction in produced waste, and reduction of energy cost. The possibility of performing multicomponent reactions under solvent-free conditions with a heterogeneous catalyst could enhance their efficiency from an economic as well as an ecological point of view [1–5]. …”