Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines

Abstract

Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines to the preparation of other heterocycles are discussed emphasizing the stereoselectivity of the reactions.

Extraction and stability of pigments obtained from pitaya bark flour (Hylocereus costaricensis)

“…However, betacyanins can also degrade and regenerate continually during storage, because the reaction is reversible, thus maintaining pigment concentrations (Gandía-Herrero et al, 2013;Silva et al, 2019). The process of pigment regeneration (Figure 1A) following refrigerated storage is based on hydrolytic products of betaine.…”

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

“…Synthetic organic chemists can take advantage of regio- and stereoselective ring openings to easily convert epoxides into diols, amino alcohols, ethers, etc. [6]. Therefore, the formation of enantiomerically pure epoxides is an essential step in the asymmetric synthesis of organic chiral compounds.…”

Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition

“…This Special Issue is aimed at offering an opportunity to all the contributors to make their results and techniques more visible, and to present the most recent findings. This Special Issue has received remarkably positive feedback, with many contributions submitted by numerous geographically diverse scientists, resulting in a collection of 19 publications, including six exhaustive review articles [2][3][4][5][6][7], and thirteen original articles [8][9][10][11][12][13][14][15][16][17][18][19][20]. Among the contributing authors, we can find countries of origin such as Algeria, Australia, Brazil, Canada, China, Croatia, Czech Republic, Egypt, India, Italy, Japan, Portugal, Romania, Russia, and Taiwan.…”

“…Multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. An exhaustive review about the recent advances in MCRs discuss the synthesis and applications of epoxides and aziridines to prepare other heterocycles, emphasizing the stereoselectivity of the reactions [7]. Synthesis of chiral derivatives of xanthones, an important class of bioactive compounds, as well the enantioselectivity in their biological activities, was also exhaustively revised [3].…”