Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition

Abstract

Chirality is a geometric property associated with the asymmetry of tridimensional features that accompanies our daily life at macroscopic as well as microscopic molecular levels [...]

Spatial Organization of Immobilized Multienzyme Systems Improves the Deracemization of Alkyl Glyceryl Ethers

“…Enzymatic deracemization usually is performed in a two-stage cascade starting from a racemate; (1) the transformation of one or both enantiomers into a prochiral intermediate and (2) transformation back into the stereocomplementary substrate molecule, now optically pure . This process achieves 100% yield of one enantiomer, in contrast to the 50% obtained in kinetic resolutions when starting from a racemic mixture .…”

Chiral Capillary Electrokinetic Chromatography: Principle and Applications, Detection and Identification, Design of Experiment, and Exploration of Chiral Recognition Using Molecular Modeling

“…Chirality plays a crucial role in life with a multidisciplinary interest—including, but not limited to, chemistry, biochemistry, food chemistry, agrochemistry, drug discovery, pharmacology, engineering, physics, and material science. Stemming from the chirality of natural amino acids, stereospecificity is a characteristic of many physiological reactions and pharmacological processes for all living systems [ 1 , 2 , 3 , 4 ].…”

Metal‐Organic Frameworks as a New Platform for Enantioselective Separations

“…These have been further used in various analytical and preparative techniques like high-performance liquid chromatography (HPLC), gas chromatography (GC), capillary electrochromatography (CEC), thin layer chromatography (TLC), stimulated moving bed (SMB) and supercritical fluid chromatography (SFC). [3,7] However, liquid chromatography (LC) and gas chromatography are the widely exploited analytical techniques for enatioseparation. [8] Despite such myriad techniques available for enantiomeric resolution, the separation of the enantiomeric pairs with high efficacy is challenging due to high cost, low versatility, poor recovery and moderate efficiencies.…”

“…[2] Molecular chirality is often followed by enantiomerism; whereby the non-superimposable mirror images of chiral molecules form pairs of enantiomers with identical physical properties but different orientation/arrangement of the atoms. [3] This trivial alteration in the arrangement of atoms changes the biological properties of the molecule and plays a vital role in various pharmaceutical, agrochemical and food industries. [4] The action of drugs on human body is dependent on chirality matching with the target molecules.…”