Stereological evaluation of the volume and volume fraction of newborns’ brain compartment and brain in magnetic resonance images

Abstract

This study presents the basic data for studies relative to newborn's brain volume fractions according to two methods. Stereological (point-counting) estimation may be accepted a beneficial and new tool for neurological evaluation in vivo research of the brain. Based on these techniques we introduce here, the clinician may evaluate the growth of the brain in a more efficient and precise manner.

Perinatal Factors and Regional Brain Volume Abnormalities at Term in a Cohort of Extremely Low Birth Weight Infants

“…Our age corrected global and structural measurements for term controls closely match post-mortem volume measurements reported by Nisari et al [38] and in vivo MRI measurements by Clouchoux and colleagues [39] but are smaller than those reported by Thompson et al [7] in neonates. These discrepancies may relate to study differences in subject race, image acquisition, or post-processing methods utilized.…”

Recent developments and the importance of the volume estimation in biomedical sciences

“…the quantitative evaluation of brain atrophy because their superior contrast resolution facilitates discrimination of the grey and white matter 31 . The in vivo comparative morphological research collects data from the newborn's total brain, cerebrum, cerebellum and bulbus/pons to try to explain the origin of neurodevelopmental mental disorders 30 . The volume of the brain, cerebellum and brain stem was also observed in the young subjects 33 .…”

Estimation of spleen volume and surface area of the newborns’ cadaveric spleen using stereological methods

“…Those studies have used Cavalieri's principle, a stereological method for organ volume measurement [1,2,9]. The volumes of organs such as heart [27], liver [33], prostate [3], ventricle [22], brain [24], and also the volume of foetus [29], have been measured using MR imaging and Cavalieri's principle.…”