Stereological Evaluation of Altered Hepatocellular Foci in Control Wistar Rats

Walsh, Kathleen M.; Razmpour, Ahmad

doi:10.1177/019262339202000104

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…With respect to foci of cellular alteration, basophilic foci were the most common in females (71.7%) and eosinophilic foci were the most common in males (51.1%). This was similar to that reported in Wistar rats by Walsh and Razmpour (1992) although the incidence is notably higher in the current study; the reason for this is unclear. Bile duct hyperplasia (21.7% in males and 43.3% in females) was similar to that reported in RCCHan:WIST rats by Weber et al (2011; 28.2% in males and 35.8% in females).…”

Section: Resultssupporting

confidence: 91%

Findings in Historical Control Harlan RCCHan™

et al. 2016

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Vehicle control Harlan RCCHan™:WIST rats were examined to provide control data for subsequent studies. The rats (180 male and 180 female) were dosed daily via oral gavage with reverse osmosis water for up to 104 weeks. At necropsy, body weights and macroscopic findings were recorded and tissues were collected for histopathology. The mean body weight at terminal sacrifice was 687 g for males and 466 g for females. The overall survival rate was 62% for males and 59% for females. The most common cause of death for males and females found dead or examined following unscheduled euthanasia was pituitary neoplasia with an incidence of 13.9% for males and 18.9% for females. Macroscopic and neoplastic and nonneoplastic microscopic findings are presented by body system.

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Section: Resultssupporting

confidence: 91%

Findings in Historical Control Harlan RCCHan™

et al. 2016

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“…Since the incidence of spontaneous hepatocellular tumors is still low even in rats maintained for their entire lifetime 14 , it is considered that most spontaneous foci do not progress to neoplasia in rats. Classification of hepatic foci by phenotype indicates that the spontaneous incidence of tigroid basophilic foci is high in rats, whereas diffusely basophilic and amphophilic foci are very rare [13][14][15][16] . However, these diffusely basophilic and amphophilic foci have been shown to increase significantly in rats treated with various genotoxic hepatocarcinogens 17,18 .…”

Section: Focus Of Cellular Alterationmentioning

confidence: 99%

A Review of Nomenclature and Diagnostic Criteria for Proliferative Lesions in the Liver of Rats by a Working Group of the Japanese Society of Toxicologic Pathology.

et al. 2003

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Abstract:The final version of the international harmonized nomenclature for proliferative lesions in rats was issued on June 21, 2000. The recommended nomenclature for proliferative lesions in the liver includes focus of cellular alteration, regenerative hepatocellular hyperplasia, cholangiofibrosis, cholangiofibroma, oval cell hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, bile duct hyperplasia, cholangioma, cholangiocarcinoma, hepatocholangiocellular adenoma, and hepatocholangiocellular carcinoma. Foci of cellular alteration are further classified into the following phenotypes: amphophilic, diffusely basophilic, tigroid basophilic, clear cell, eosinophilic, and mixed (basophilic/eosinophilic). Hepatocellular carcinomas are divided into 3 types based on their growth patterns: acinar, solid, and trabecular. In consideration of this international harmonized nomenclature, the current classification, terminology, and diagnostic criteria for prolifrative lesions in the liver of rats recommended by the Japanese Society of Toxicologic Pathology (JSTP) were reviewed by a Working Group of the JSTP. The hepatic proliferative lesions reviewed by the present Working Group included lesions of hepatocellular, cholangiocellular, mixed hepatocholangiocellular, sinusoidal, and hemangioendothelial origins. Any comments and questions on these lesions were discussed among pathologists in the Working Group and the results of discussions were presented at the 1st seminar on the continuing education program

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Stereological Evaluation of Altered Hepatocellular Foci in Control Wistar Rats

Cited by 2 publications

References 19 publications

Findings in Historical Control Harlan RCCHan™

Findings in Historical Control Harlan RCCHan™

A Review of Nomenclature and Diagnostic Criteria for Proliferative Lesions in the Liver of Rats by a Working Group of the Japanese Society of Toxicologic Pathology.

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