Findings in Historical Control Harlan RCCHan™

Blankenship, Brad; Eighmy, Johnnie J.; Hoffmann, G; Schroeder, Melanie; Sharma, Alok; Sorden, Steven D.

doi:10.1177/0192623316660768

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…The cause of death was attributed to various tumors that were responsible for the cause of death in the studies evaluated; however, the most common tumor leading to death were pituitary neoplasms (44.7% in males and 58.1% in females) which is similar in many rat oncogenicity studies of different rat strains. 2,12 The other common neoplasms (>1%) were mammary neoplasm in females (24.6%), skin neoplasms (5.7% in males and 1.1% in females), hematolymphoid neoplasms (2.5% in males, 0.7% in females), and neoplasms in brain (1.5% in males and 0.5% in females). Mammary gland neoplasm, considered a major cause of unscheduled euthanasia and death, 13 was the second most common neoplasm recorded in females.…”

Section: Resultsmentioning

confidence: 99%

“…Fibroadenoma and mammary carcinoma are the most common mammary neoplasms noted in other studies in rats of different strains. 6,2,12 Other mammary tumors of low incidence included adenolipoma, anaplastic carcinoma, carcinosarcoma, and fibroma (Table 10; Figures 18 and 19). Carcinosarcoma contains both epithelial and mesenchymal cell components which are malignant.…”

Section: Mammary Glandmentioning

confidence: 99%

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Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies

Kumar,

Bockenstedt,

Laast

et al. 2023

Toxicol Pathol

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Data collected from approximately 1800 male and 1800 female Sprague-Dawley (SD) rats used in 104-week carcinogenicity studies were archived in a historical control database at Labcorp Early Development, Inc, and the neoplastic microscopic observation data from these rats were retrospectively evaluated. Historical control data can provide useful information on the range and incidence of spontaneously occurring background neoplasms in the species and strain of the test animal used in different types of toxicity studies, including studies of differing lengths, delivery of test article, and test animal. Some of the most common malignant findings noted included fibrosarcoma of skin/subcutis and thyroid C-cell carcinoma in males (2.1% each) while mammary gland carcinoma and pituitary carcinoma (25% and 2.6%) were most common in females. Pituitary adenoma of pars distalis was found to be the most prevalent benign neoplasm in both males and females (56.4% and 77.1%). Fibroadenoma of mammary gland (35.6%) and thyroid C-cell adenoma (8.5%) were the second and third most common benign tumors in female SD rats. In males, the thyroid C-cell adenoma (10.9%) and benign pheochromocytoma (8.9%) were the second and third most common tumors.

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Section: Resultsmentioning

confidence: 99%

Section: Mammary Glandmentioning

confidence: 99%

Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies

Kumar,

Bockenstedt,

Laast

et al. 2023

Toxicol Pathol

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“…Otherwise, degenerate and inflammatory aortic changes have not been reported in adults of strains of rats and mice commonly used in nonclinical safety studies. 13,14 We are not aware of reports of spontaneous aortic aneurysm in nonrodent species used in toxicity testing.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat

et al. 2021

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Aneurysms of the ascending aorta, unrelated to xenobiotic administration, are described in 5 rats and 2 mice in nonclinical safety studies conducted at Charles River Laboratories (CRL) sites over the past 10 years. The most prominent microscopic finding was focal dilation with disruption of the wall of the ascending aorta with chronic adventitial inflammation or fibroplasia. The pathogenesis of this finding is unknown. There were no associated macroscopic findings, clinical abnormalities, or vascular lesions elsewhere. The results of a search of historical control data from toxicology studies of 1 day to 72 weeks’ duration performed at CRL for aortic findings from 5900 mice and 23,662 rats are also reported. Aortic lesions are uncommon in mice and rats used in nonclinical safety studies, but toxicologic pathologists should be aware that aneurysms of the ascending aorta with fibroplasia and inflammation in the aortic wall and adventitia may occur spontaneously or iatrogenically, as they have the potential to impact interpretation in toxicology studies.

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“…However, few reports have been published so far discussing a comprehensive analysis of spontaneous lesions in aged rats of this strain, especially non-neoplastic lesions. Only Blankenship et al reported microscopic findings of various lesions seen in routine toxicological studies 6 . The present study highlights our experience with naturally occurring neoplastic and non-neoplastic lesions in 39 male RccHan:WIST rats at 2 years of age.…”

mentioning

confidence: 99%

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats

et al. 2020

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Histopathological information about spontaneous lesions in aged Hannover Wistar rats is limited. In this study, we describe spontaneous lesions found in 39 male RccHan:WIST rats used as a control in a carcinogenicity study. Neoplastic lesions were frequently seen in the endocrine system, such as pituitary adenomas in the pars distalis. This strain exhibited a high incidence of thymoma (10.3%), compared to other strains. We encountered an oligodendroglioma, a pituitary adenoma of the pars intermedia, and a prostate adenocarcinoma, which are comparatively rare in rats. While the variety and incidence of non-neoplastic lesions were similar to those in other strains, several interesting lesions occurred with relatively high incidence, including "harderianization" of the extraorbital lacrimal gland, common bile duct ectasia, and hyperplasia of pulmonary endocrine cells in the lung. Furthermore, comparative analyses demonstrated that the severity of chronic progressive nephropathy and murine progressive cardiomyopathy in RccHan:WIST rats was less than that in F344 rats. (

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Findings in Historical Control Harlan RCCHan™

Cited by 11 publications

References 19 publications

Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies

Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies

Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats

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