Stereolithography based 3D-printed microfluidic device with integrated electrochemical detection

Costa, Brenda Maria de Castro; Griveau, Sophie; Bédioui, Féthi; Orlye, Fanny d’; Silva, José Alberto F. da; Varenne, Anne

doi:10.1016/j.electacta.2022.139888

Cited by 17 publications

(12 citation statements)

References 39 publications

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“…However, electrode performance is only demonstrated using outer-sphere molecules and more research needs to be carried out to know the potential of this technology in real settings. 110 Ion-selective membranes have been also fabricated using SLA and showed the versatility of being tuned for different analyte detection such as potassium, bilirubin, and benzalkonium. 111…”

Section: Real-time Electrochemical Sensing: An Enriching Complement T...mentioning

confidence: 99%

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

et al. 2022

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Section: Real-time Electrochemical Sensing: An Enriching Complement T...mentioning

confidence: 99%

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

et al. 2022

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“…In another recent study, Costa et al developed a microfluidic device with electrochemical detection. 13 In their work, SLA 3D printing was combined with a modified resin, which consisted of mixing graphite powder into the Formlabs Clear V4 resin to develop a microfluidic device with integrated electrodes for a simpler and more accessible gel electrophoresis device. Furthermore, Esparza et al developed a capillary circuit microfluidic device to study the effects of microfeatures on cell structure and orientation-specific organization.…”

Section: Introductionmentioning

confidence: 99%

“…They found that sterilization of the resins with ethanol and UV light was sufficient, and autoclave sterilization was not needed for these studies. In another recent study, Costa et al developed a microfluidic device with electrochemical detection . In their work, SLA 3D printing was combined with a modified resin, which consisted of mixing graphite powder into the Formlabs Clear V4 resin to develop a microfluidic device with integrated electrodes for a simpler and more accessible gel electrophoresis device.…”

Section: Introductionmentioning

confidence: 99%

Materials Characterization of Stereolithography 3D Printed Polymer to Develop a Self-Driven Microfluidic Device for Bioanalytical Applications

Stark,

Gamboa,

Esparza

et al. 2024

ACS Appl. Bio Mater.

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Stereolithography (SLA) 3D printing is a rapid prototyping technique and reproducible manufacturing platform, which makes it a useful tool to develop advanced microfluidic devices for bioanalytical applications. However, limited information exists regarding the physical, chemical, and biological properties of the photocured polymers printed with SLA. This study demonstrates the characterization of a commercially available SLA 3D printed polymer to evaluate the potential presence of any time-dependent changes in material properties that may affect its ability to produce functional, capillary-action microfluidic devices. The printed polymer was analyzed with Fourier transform infrared–attenuated total reflectance, contact angle measurements, tensile test, impact test, scanning electron microscopy, and fluid flow analysis. Polymer biocompatibility was assessed with propidium iodide flow cytometry and an MTT assay for cell viability. The material characterization and biocompatibility results were then implemented to design and fabricate a self-driven capillary action microfluidic device for future use as a bioanalytical assay. This study demonstrates temporally stable mechanical properties and biocompatibility of the SLA polymer. However, surface characterization through contact angle measurements shows the polymer’s wettability changes over time which indicates there is a limited postprinting period when the polymer can be used for capillary-based fluid flow. Overall, this study demonstrates the feasibility of implementing SLA as a high-throughput manufacturing method for capillary action microfluidic devices.

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“…Using 3D printing, highlycomplex prototypes and small-series microfluidic chips can be fabricated in a single step based on digital computerassisted design (CAD) information and in short amounts of time. Various 3D printing methods including fused deposition modeling (FDM) [23][24][25][26], inkjet printing [27,28] and stereolithography (SLA) [29,30] have been reported for the fabrication of microfluidic devices. Several groups reviewed these methods in terms of resolution, costs, and time [13,[31][32][33].…”

Section: Introductionmentioning

confidence: 99%

On‐Chip Chemical Synthesis Using One‐Step 3D Printed Polyperfluoropolyether

Goralczyk

Mayoussi

Sanjaya

et al. 2022

Chemie Ingenieur Technik

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Three-dimensional (3D) printing has already shown its high relevance for the fabrication of microfluidic devices in terms of precision manufacturing cycles and a wider range of materials. 3D-printable transparent fluoropolymers are highly sought after due to their high chemical and thermal resistance. Here, we present a simple one-step fabrication process via stereolithography of perfluoropolyether dimethacrylate. We demonstrate successfully printed microfluidic mixers with 800 mm circular channels for chemistry-on-chip applications. The printed chips show chemical, mechanical, and thermal resistance up to 200 °C, as well as high optical transparency. Aqueous and organic reactions are presented to demonstrate the wide potential of perfluoropolyether dimethacrylate for chemical synthesis.

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Stereolithography based 3D-printed microfluidic device with integrated electrochemical detection

Cited by 17 publications

References 39 publications

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

Materials Characterization of Stereolithography 3D Printed Polymer to Develop a Self-Driven Microfluidic Device for Bioanalytical Applications

On‐Chip Chemical Synthesis Using One‐Step 3D Printed Polyperfluoropolyether

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