Stenotrophomonas maltophilia bacteraemia in cancer patients: report on 31 cases

Krčméry, V.; Pichňa, P.; Oravcova, E.; Lacka, J.; Kukuckova, E.; Studena, M.; Grausova, S.; Stopkova, K.; Krupova, I.

doi:10.1016/s0195-6701(96)90129-2

Cited by 26 publications

(15 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were consistent with what has been reported in the literature, namely that bacteremia is a common manifestation of S. maltophilia infection and that the infection, which appears to be increasing in frequency, 3,4 is commonly associated with CR-BSI. [1][2][3][4][5][6][7][8] For example, in 1990 Elting and Bodey 4 found that at our institution CVCs were most likely the leading source of S. maltophilia and nonaeruginosa Pseudomonas species bacteremia. The results of the current study also found differences in the clinical profiles and presentations of secondary S. maltophilia BSIs and CR S. maltophilia bacteremias.…”

Section: Discussionsupporting

confidence: 92%

“…1,2 This organism presents a therapeutic challenge and in cancer patients is associated with high morbidity and mortality rates. 3,4 Infection with this pathogen commonly manifests as bacteremia, [1][2][3][4][5][6][7][8][9][10] although it can cause a wide spectrum of other infections as well. [11][12][13][14][15][16][17][18][19][20][21] Several studies have identified major risk factors for the infection, including neutropenia, prolonged hospitalization, previous antibiotic use, steroid use, mechanical ventilator support, and the use of medical devices such as prosthetic heart valves, urinary catheters, and indwelling central venous catheters (CVCs).…”

mentioning

confidence: 99%

“…[11][12][13][14][15][16][17][18][19][20][21] Several studies have identified major risk factors for the infection, including neutropenia, prolonged hospitalization, previous antibiotic use, steroid use, mechanical ventilator support, and the use of medical devices such as prosthetic heart valves, urinary catheters, and indwelling central venous catheters (CVCs). [1][2][3][4][5][6][7][8][9][10]17,18 However, to our knowledge very little information is available regarding how often CVCs are the source of the bacteremia. 22 In recent years, S. maltophilia has been found to adhere to abiotic surfaces such as intravenous cannulae, polyvinyl chloride, glass, and Teflon.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients

Boktour

Hanna

Ansari

et al. 2006

Cancer

View full text Add to dashboard Cite

There is no instrument to measure severity of sickle cell disease (SCD) in pediatric patients that is generally accepted. The aim of this study was to develop and validate a severity index for SCD in children. We developed an index consisting of 12 items and tested its validity of the index using data from 92 children. We tested whether different scores were obtained for patients classified by severity both subjectively and objectively by a partially validated existing index. Furthermore, we tested whether the index could differentiate patients classified according to genotype or the number of α‐gene deletions and evaluated whether the score on the index was correlated with the average number and days of hospitalizations/year, age and a risk of death score. We explored the effect of three different weighting systems (Score A, B, and C) to summarize these items. All weightings demonstrated a significant difference between the scores of mild, moderate, and severely affected patients, as classified by a subjective rating or with an existing index (P < 0.01). The index clearly differentiated patients by genotype (P < 0.01) or α‐gene deletions (P < 0.01). The correlation with hospitalization was moderate. Age and the risk of death score were weakly associated with the pediatric severity index for SCD. This is the first pediatric SCD severity index that was developed and validated using modern clinimetric methodology. The validity and reliability of this index should be further evaluated in a prospective study including a larger cohort, preferably diagnosed at birth. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients

Boktour

Hanna

Ansari

et al. 2006

Cancer

View full text Add to dashboard Cite

show abstract

“…Recognized risk factors for S. maltophilia bacteremia in oncology patients have included severe and prolonged neutropenia, intravascular devices, prolonged hospital stay, aggressive chemotherapy treatment, and increased antibiotic pressure. 2,[6][7][8]23,24 Severe mucositis was recently identified as a significant risk factor for S. maltophilia bacteremia in the investigation of an outbreak among patients receiving bone marrow transplants. 8 Our study confirmed the association of severe mucositis with S. maltophilia bacteremia in oncology patients.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors ForStenotrophomonas MaltophiliaBacteremia In Oncology Patients: A Case–Control Study

Apisarnthanarak¹,

Mayfield

Garison

et al. 2003

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

Objective:To characterize risk factors for Stenotrophomonas maltophilia bloodstream infection in oncology patients.Design:A 3:1 case–control study.Setting:Stem Cell Transplant and Leukemic Center at Barnes–Jewish Hospital (St. Louis), a 1,442-bed, tertiary-care teaching hospital with a 26-bed transplantation ward.Method:From June 1999 to April 2001,13 patients with S. maltophilia bacteremia were compared with 39 control-patients who were on the transplantation unit on the same day as the case-patients' positive blood cultures. Information collected included patient demographics, medical history, history of transplantation, transplantation type, graft versus host disease, neutropenia, antibiotic use, chemotherapy, mucositis, diarrhea, the presence of central venous catheter(s), cultures, and concomitant infections.Results:Significant risk factors for S. maltophilia bacteremia included severe mucositis (7 [53.8%] of 13 vs 8 [20.5%] of 39; P = .034), diarrhea (7 [53.8%] of 13 vs 8 [20%] of 39; P = .034), and the use of metronidazole (9 [69.2%] of 13 vs 8 [20.5%] of 39; P = .002). In addition, the number of antibiotics used (median, 9 vs 5; P < .001), duration of mucositis (median, 29 vs 15 days; P = .032), and length of hospital stay (median, 34 vs 22 days; P = .017) were significantly different between case- and control-patients. Nine S. maltophilia isolates tested by pulsed-field gel electrophoresis were found to be distinctly different.Conclusion:Interventions to ameliorate the severity of mucositis, reduce antibiotic pressure, prevent diarrhea, and promote meticulous central venous catheter care may help prevent S. maltophilia bloodstream infection in oncology patients. The role of gastrointestinal tract colonization as a potential source of S. maltophilia bacteremia in oncology patients deserves further investigation.

show abstract

“…Stenotrophomonas maltophilia (S. maltophilia) is a Gram-negative aerobic bacillus (1) that is increasingly recognized as an important cause of nosocomial infection, especially in debilitated and immunocompromised hosts (2)(3)(4)(5)(6). It is associated with significant morbidity and mortality rates.…”

Section: Introductionmentioning

confidence: 99%

Two Episodes of Stenotrophomonas maltophilia Endocarditis of Prosthetic Mitral Valve: Report of a Case and Review of the Literature

Kim

Kang

et al. 2002

J Korean Med Sci

View full text Add to dashboard Cite

Stenotrophomonas maltophilia (previously named Xanthomonas maltophilia) is an aerobic, non-fermentive, Gram-negative bacillus that is wide spread in the environment. It was considered to be an organism with limited pathogenic potential, which was rarely capable of causing diseases in human other than those who were in debilitated or immunocompromised state. More recent studies have established that Stenotrophomonas maltophilia can behave as a true pathogen. Endocarditis due to this organism is rare, and only 24 cases of Stenotrophomonas maltophilia endocarditis have been reported in the medical literature. Most cases were associated with risk factors, including intravenous drug abuse, dental treatment, infected intravenous devices, and previous cardiac surgery. We present a case with two episodes of Stenotrophomonas maltophilia endocarditis after mitral valve prosthesis implantation, which was treated with antibiotics initially, and a combination of antibiotics and surgery later. To our knowledge, this is the first case of repetitive endocarditis due to Stenotrophomonas maltophilia.

show abstract

Stenotrophomonas maltophilia bacteraemia in cancer patients: report on 31 cases

Cited by 26 publications

References 5 publications

Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients

Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients

Risk Factors ForStenotrophomonas MaltophiliaBacteremia In Oncology Patients: A Case–Control Study

Two Episodes of Stenotrophomonas maltophilia Endocarditis of Prosthetic Mitral Valve: Report of a Case and Review of the Literature

Contact Info

Product

Resources

About