Stem cells in psoriasis

Hou, Ruixia; Li, Junqin; Niu, Xuping; Liu, Ruifeng; Chang, Wenjuan; Zhao, Xincheng; Wang, Qiang; Li, Xinhua; Yin, Guohua; Zhang, Kaiming

doi:10.1016/j.jdermsci.2016.11.006

Cited by 23 publications

(23 citation statements)

References 54 publications

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“…Under selective inflammatory stimulus, MSCs isolated from skin can modify their phenotype and anti-inflammatory intrinsic properties, becoming a source of several proinflammatory cytokines on their own, thus promoting and sustaining the inflammatory status in the tissue from which they were isolated. 25,26 It is reasonable that the early inflammatory status in HS could promote the upstream milieu of T H 1 to T H 17 cytokines, activating MSCs from a quiescent toward an inflammatory status, as assessed in other inflammatory diseases of the skin. [16][17][18]27,28 In this regard, MSCs could be more than a passive spectator in the inflammatory process of HS, becoming an active source of several mediators able to amplify the inflammatory disintegration of infundibular keratinocytes and sebaceous gland homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa

et al. 2018

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“…The pathogenic factors of psoriasis such as genetic background, viral infection, metabolic syndromes, oxidative stress and immune responses have been reported. 17 However, despite extensive studies on the pathogenesis of psoriasis, the detailed mechanism of psoriasis remains elusive.…”

Section: Discussionmentioning

confidence: 99%

The Amelioration Effect of the Ethanolic Extract of Cnidium officinale in Mice with Imiquimod-induced Psoriasis-like Skin Lesion

et al. 2018

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− Psoriasis is an auto-immune skin disease, which is characterized by the excessive generation of plaques on the skin with typically a long-lasting red, itchy and scaly symptoms. Imiquimod, which has been used for the treatment of external genital warts, actinic keratosis, and superficial basal cell carcinoma, induced of psoriasis-like skin disorders with skin erythema and thickness in mice. In the present study, we tried to find the bioactive herbal extract against imiquimod-induced psoriasis-like skin disorder in mice. During the searching of the herbal extract with anti-psoriatic effect, the ethanolic extract of Cnidium officinale ameliorated imiquimodinduced psoriasis-like skin disorder in mice. The morphological evaluation, H&E staining and Psoriasis Area and Severity Index (PASI) score showed that ear and back thickness, and erythema induced by imiquimod were significantly reversed after the treatment of the cream of the ethanolic extract of C. officinale. The overexpressed myeloperoxidase (MPO) and keratin 6A levels were decreased by the treatment of C. officinale cream. Also, IFN-γ, c-fos and IκB-α mRNA levels, which are related to the progression of psoriasis, were reduced by C. officinale cream. Thus, the ethanolic extract of C. officinale ameliorated psoriasis-like skin disorder induced by imiquimod and might be the therapeutic agent for psoriasis.

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“…The role of epidermal stem cells (ESC) in disorders associated to psoriasis is currently not fully clarified, studies regarding this aspect require specific attention due to the fact that ESC are precursors of skin cells and structures involved in the development of psoriasis like keratinocytes. Considering the studies collected to date, several kinds of stem cells/progenitor cells appear to be involved in a multisystem disease like cutaneous psoriasis [34].…”

Section: Psoriasismentioning

confidence: 99%

Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration

Ahmadi-Ashtiani

Bishe

Baldisserotto

et al. 2020

IJMS

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Cutaneous stem cells, gained great attention in the field of regenerative medicine as a potential therapeutic target for the treatment of skin and hair disorders and various types of skin cancers. Cutaneous stem cells play a key role in several processes like the renovation of skin structures in the condition of homeostasis and after injuries, the hair follicle growth and the reconstruction and production of melanocytes. Thus, gaining effective access to skin stem cells for therapeutic interventions that often involve active molecules with non-favorable characteristics for skin absorption is a valuable achievement. The topical route with high patient compliance and several other benefits is gaining increasing importance in basic and applied research. However, the major obstacle for topical drug delivery is the effective barrier provided by skin against penetration of the vast majority of exogenous molecules. The research in this field is focusing more and more on new strategies to circumvent and pass this barrier effectively. In this article the existing approaches are discussed considering physical and chemical methods along with utilization of novel drug delivery systems to enhance penetration of drugs to the skin. In particular, attention has been paid to studies finalized to the delivery of molecules to cutaneous stem cells with the aim of transferring signals, modulating their metabolic program, inducing physiological modifications and stem cell gene therapy.

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Stem cells in psoriasis

Cited by 23 publications

References 54 publications

Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa

Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa

The Amelioration Effect of the Ethanolic Extract of Cnidium officinale in Mice with Imiquimod-induced Psoriasis-like Skin Lesion

Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration

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