Context: In this article we are going to clarify the importance and practical role of liposomes in cosmetics. Evidence Acquisition: In pharmaceutics, we have a vast area for designing different dosage forms in order to deliver the active pharmaceutical ingredient to its site of action. However, in cosmetics, since skin is the first defensive barrier against external factors and prevents many substances from entering the underlying layers or systemic circulation, there are some limitations to deliver the active ingredient to the target site. Results: Therefore, we investigated the role of liposomes in cosmetics, and reviewed references in which the properties and applications of liposomes in cosmetics have been studied. Conclusions: This article explains the constituents of liposomes, how they have been discovered and entered the cosmetic field, as well as their definition. Subsequently, it introduces different types of cosmetic liposomes that can be utilized in various cosmetic formulations depending on their specific properties and finally, the benefits of application of liposomes in cosmetics are taken into consideration. By using liposomes, we are able to overcome some restrictions such as low penetration, solubility, stability, duration of effect and high side effects or costs, and improve some other characteristics.

Cutaneous stem cells, gained great attention in the field of regenerative medicine as a potential therapeutic target for the treatment of skin and hair disorders and various types of skin cancers. Cutaneous stem cells play a key role in several processes like the renovation of skin structures in the condition of homeostasis and after injuries, the hair follicle growth and the reconstruction and production of melanocytes. Thus, gaining effective access to skin stem cells for therapeutic interventions that often involve active molecules with non-favorable characteristics for skin absorption is a valuable achievement. The topical route with high patient compliance and several other benefits is gaining increasing importance in basic and applied research. However, the major obstacle for topical drug delivery is the effective barrier provided by skin against penetration of the vast majority of exogenous molecules. The research in this field is focusing more and more on new strategies to circumvent and pass this barrier effectively. In this article the existing approaches are discussed considering physical and chemical methods along with utilization of novel drug delivery systems to enhance penetration of drugs to the skin. In particular, attention has been paid to studies finalized to the delivery of molecules to cutaneous stem cells with the aim of transferring signals, modulating their metabolic program, inducing physiological modifications and stem cell gene therapy.