Stem cell transplantation for induction of remission in medically refractory Crohn’s disease

El‐Nakeep, Sarah; Shawky, Ahmed M.; Abbas, Sara F; Latif, Osama Abdel

doi:10.1002/14651858.cd013070.pub2

Cited by 6 publications

(2 citation statements)

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“…The increase in Fe in the leaves has a role in the important cytochromes formation in the photosynthesis and respiration processes, and it enters as an enzyme in the chlorophyll molecule [18]. Foliar application of nutrients, organic materials, amino acids, and auxins contributes to their easy entry into the leaves and their participation in metabolic processes, which causes improvement in plant growth indicators in general, hence the accumulation of carbohydrates ,N, P, K, Fe and Mn [19]. The presence of auxins in foliar fertilizer contributes to cell division and increases its carbohydrate content.…”

Section: Resultsmentioning

confidence: 99%

Impact of Foliar Application with Amino Alexin and a Mixture of Marvel Fertilizer with Growth Regulator (Floratone) in Physio-Biochemical Parameters of Bitter Orange Saplings (Citrus aurantium L.)

Hashem,

Abdulkadhim

2024

IOP Conf. Ser.: Earth Environ. Sci.

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This experiment was implemented during 202l -2022 season as a factoria1 experiment (4×3) relying on (R.C.B.D.). Two factors were tested in this experiment: first factor is: Foliar application at 4 levels: (0, l, 2, 3) ml L-1 from a mixture of MARVEL fertilizer with plant growth regulator (FLORATONE (6 g L-1). Second factor is Foliar application at three levels of Amino Alexin fertilizer (0, l.5, 3) ml L-1. Results were summarized that foliar application for a combination of (MARVEL + FLORATONE) at (3 m1 L-1) had a positive impact in physio-Biochemical Parameters (leaf area, chlorophyll, carbohydrates, N, P) that recorded (42.24 cm2, 24.93 Spad, 33.43, 1.36%, 0.57%) respectively. Concentration (2 m1 L-1 (caused a noticeable increase in (K, Fe, Mn) that recorded(1.48%, 167.2 mg g-1, 36.98 mg g-1) On the relay by analogy with control. Amino Alexin (3 m1 L-1) had a positive impact in physio-Biochemical Parameters (leaf area, chlorophyll, carbohydrates, N, P, K, C/N ratio, Fe, Mn) witch recorded (41.71, 26.42, 34.65, 1.40, 0.60, 1.53, 24.67, 164.2, 34.95) respectively compared to control. Double interaction effect between the two factors was significant in all physio-Biochemical Parameters compared to control.

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Section: Resultsmentioning

confidence: 99%

Impact of Foliar Application with Amino Alexin and a Mixture of Marvel Fertilizer with Growth Regulator (Floratone) in Physio-Biochemical Parameters of Bitter Orange Saplings (Citrus aurantium L.)

Hashem,

Abdulkadhim

2024

IOP Conf. Ser.: Earth Environ. Sci.

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“…Currently, there are still many non-traditional therapies being discovered for patients with CD. Stem cell transplantation has been proven to be effective in treating CD, but it is difficult to operate and expensive [51,52]. FMT is also an emerging treatment [53,54], but it depends on stool banks and certain medical technologies [55].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease

Li,

Sun,

Lai

et al. 2024

J Transl Med

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Background Dysbiosis of the gut microbiota is pivotal in Crohn’s disease (CD) and modulated by host physiological conditions. Hyperbaric oxygen therapy (HBOT) is a promising treatment for CD that can regulate gut microbiota. The relationship between HBOT and the gut microbiota in CD remains unknown. Methods CD patients were divided into an HBOT group (n = 10) and a control group (n = 10) in this open-label prospective interventional study. The fecal samples before and after HBOT were used for 16 S rRNA gene sequencing and fecal microbiota transplantation (FMT). A colitis mouse model was constructed using dextran sulfate sodium, and intestinal and systematic inflammation was evaluated. The safety and long-term effect of HBOT were observed. Results HBOT significantly reduced the level of C-reactive protein (CRP) (80.79 ± 42.05 mg/L vs. 33.32 ± 18.31 mg/L, P = 0.004) and the Crohn’s Disease Activity Index (CDAI) (274.87 ± 65.54 vs. 221.54 ± 41.89, P = 0.044). HBOT elevated the declined microbial diversity and ameliorated the altered composition of gut microbiota in patients with CD. The relative abundance of Escherichia decreased, and that of Bifidobacterium and Clostridium XIVa increased after HBOT. Mice receiving FMT from donors after HBOT had significantly less intestinal inflammation and serum CRP than the group before HBOT. HBOT was safe and well-tolerated by patients with CD. Combined with ustekinumab, more patients treated with HBOT achieved clinical response (30%vs.70%, P = 0.089) and remission (20%vs.50%, P = 0.160) at week 4. Conclusions HBOT modulates the dysbiosis of gut microbiota in CD and ameliorates intestinal and systematic inflammation. HBOT is a safe option for CD and exhibits a promising auxiliary effect to ustekinumab. Trial registration Chinese Clinical Trial Registry, ChiCTR2200061193. Registered 15 June 2022, https://www.chictr.org.cn/showproj.html?proj=171605.

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