Stem Cell Therapy for Diabetic Foot Ulcers: Theory and Practice

Abstract

Diabetic foot ulcers are associated with increases in limb amputation, morbidity, and mortality. Recently, a stem cell application is emerging as promising adjuvant therapy. We presented available remedies by conducting a literature review on the application, safety, and efficacy of stem cell therapy. Relevant literature, including randomized control trials and article journals, was obtained from reputable search engines (PubMed, Scopus, and Web of Science). We analyzed five credible cohorts, with variable sources of stem cells, in a total of 216 participants, 151 males and 65 females, age ( mean ± SD ) of 64.5 ± 9.6 years. With an average success of 86.41% in all Wagner-II lesions, mesenchymal SCA (stem cell application) is safe and effective, hence can significantly prevent limb amputation.

Mesenchymal stem cell therapy in diabetic foot ulcer: An updated comprehensive review

“…It can also promote ulcer healing and is thought to be a vital approach in the management of DFU. 16,61,62 TCC is proven to be significantly superior to common dressing changes and other offloading ways of boosting ulcer healing and minimizing infection. 63,64 HBOT is a promising approach to overcome local hypoxia.…”

“…When compared to specifically made footwear, it can reduce the load by itself, and it mechanically aids in lowering and redistributing the stresses on the DFU. It can also promote ulcer healing and is thought to be a vital approach in the management of DFU 16,61,62 . TCC is proven to be significantly superior to common dressing changes and other offloading ways of boosting ulcer healing and minimizing infection 63,64 …”

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

“…The several ways to relieve foot load include orthopedic walking aids and modified shoes used in DFU treatment ( 40 ). Compared with the modified shoes, the total contact casting bracing can reduce the load on the sole, mechanically help to reduce and redistribute the pressure of the DFU, and contribute to the repair of ulcers, and is considered an important means for the treatment of DFU ( 41 , 42 ). However, the production of total contact casting bracing requires personalization for different patients.…”