Cerium oxide nanoparticles in diabetic foot ulcer management: Advances, limitations, and future directions

Xu, Haotian; Li, Shiqi; Ma, Xiaoxuan; Xue, Tingting; Shen, Fang; Ru, Yi; Jiang, Jingsi; Kuai, Le; Li, Bin; Zhao, Hang; Ma, Xin

doi:10.1016/j.colsurfb.2023.113535

Cited by 4 publications

(2 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…Diabetic foot (DF) is one of the most prevalent consequences of diabetes mellitus, and patients with DF who are not effectively managed are prone to wound worsening, increasing the risk of sepsis and amputation. 1 It is estimated that up to 20% of diabetic patients are hospitalized for DF and that the risk of death within 5 years is 2.5 times higher in patients affected by DF than in individuals with diabetes alone. 2 , 3 However, current interventions or vascular bypass surgery are not sufficient to fundamentally address the pathological basis of extensive vasoconstriction and obstruction and nerve and tissue damage in DF.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of stem cell therapy for diabetic foot: Clinical evidence from meta‐analyses

Zhang,

Li,

Liu

2023

International Wound Journal

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To assess the clinical data on the effectiveness of stem cell therapy for diabetic foot (DF) based on recent systematic reviews and meta‐analyses (SRs/MAs). SRs/MAs that evaluate the clinical evidence on the efficacy of stem cell therapy for DF were identified through a systematic search in public databases. The methodological quality and evidence quality of the included SRs/MAs were assessed separately by two researchers. Eight SRs/MAs were included in this analysis. Since there were no registered protocol or exclusion criteria for the included SRs/MAs, the methodological quality was rated as critically low. There was no high‐quality evidence available for the outcomes, and the evidence quality ranged from critically low to moderate. Evidence degradation was most commonly caused by the risk of bias, followed by imprecision, publication bias and inconsistency. In conclusion, stem cell therapy may be effective for DF. However, this conclusion should be approached with caution, considering the quality of the supporting SRs/MAs.

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Section: Introductionmentioning

confidence: 99%