Stem cell therapies in ocular repair, regeneration, and diseases

Taher, Eman E.; El‐Alfy, Mohamed; Elsawah, Kareem

doi:10.1016/b978-0-12-819713-4.00004-9

Cited by 1 publication

(1 citation statement)

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“…It presents typical characteristics of soft biological materials: incompressibility, non-linear elastic behavior, and viscoelasticity [ 3 ]. Histologically, the cornea is divided into five layers: the epithelium, Bowman’s layer, Stroma, Descemet’s membrane, and endothelium [ 4 , 5 , 6 ]. The corneal stroma comprises 90% of the total corneal thickness and consists of keratocytes, collagenous lamellae, and proteoglycan ground substance.…”

Section: Introductionmentioning

confidence: 99%

Layer-by-Layer Investigation of Ultrastructures and Biomechanics of Human Cornea

Rates

Almeida

Costa

et al. 2022

IJMS

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The cornea is an avascular, innervated, and transparent tissue composed of five layers: the epithelium, Bowman’s layer, stroma, Descemet’s membrane, and endothelium. It is located in the outermost fraction of the eyeball and is responsible for the refraction of two-thirds of light and protection from external mechanical damage. Although several studies have been done on the cornea on the macroscopic scale, there is a lack of studies on the micro-nanoscopic scale, especially an analysis evaluating the cornea layer by layer. In this study, atomic force microscopy (AFM) was employed to assess four layers that form the cornea, analyzing: adhesion, stiffness, and roughness. The results showed microvilli in the epithelial and endothelial layers, pores in the basement membrane, and collagen fibers in the Stroma. These data increase the knowledge about the human cornea layers’ ultrastructures and adds new information about its biophysical properties.

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