Stem Cell Proliferation Pathways Comparison between Human Exfoliated Deciduous Teeth and Dental Pulp Stem Cells by Gene Expression Profile from Promising Dental Pulp

Recent Advances in Pulp Capping Materials: An Overview

“…In addition, gene expression profile of DSPCs and SHED were analyzed by using DNA microarray. They concluded that SHED has got significantly higher proliferation rate than that of DSPCs and BMMSCs and this could be a desirable option as a cell source for therapeutic applications [30].…”

Induced in vitro differentiation of neural-like cells from human exfoliated deciduous teeth-derived stem cells

“…Therefore, there are many interests in banking person-specific tooth-derived stem cells (Arora et al, 2009;Perry et al, 2008). The proliferation rate of SHED is significantly higher than that of DPSCs and BM-MSCs (Nakamura et al, 2009;Takeda et al, 2008). It is interesting to note that DPSC isolation is possible for at least five days after tooth extraction, which implies that immediate processing after extraction may not be necessary for successful DPSC banking.…”

Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration?

“…SHED have been shown to express the MSC-related cell surface markers, CD13, CD29, CD44, CD73, CD90, CD105, CD146, CD166, and STRO-1 [37][38][39]. SHED expressed high levels of the growth factors, basic fibroblast growth factor (bFGF), connective tissue growth factor (CTGF), transforming growth factor (TGF)-β2, and TGF-β3, compared with DPSC [40]. These growth factors and known to regulate the biological activities of many types of cells, and thus, may be secreted from SHED and function in an autocrine manner to stimulate their proliferation.…”