Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients

Täubert, Helge; Würl, Peter; Greither, Thomas; Kappler, Matthias; Bache, Matthias; Bartel, Frank; Kehlen, Astrid; Lautenschläger, Christine; Lc, Harris; Kaushal, Deepak; Füssel, S.; Meye, Axel; Böhnke, Anja; Schmidt, Hannelore; Hj, Holzhausen; Hauptmann, Steffen

doi:10.1038/sj.onc.1210530

Cited by 48 publications

(49 citation statements)

References 19 publications

(30 reference statements)

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“…Because of the primitive appearance of these neoplasms, we investigated expression of several markers that characterize stem cells, including survivin, CD117, CD105, and nestin [22][23][24]. Survivin, a member of the inhibitors of apoptosis gene family, is highly expressed in embryonal tissues and is a marker of aggressive clinical behavior in sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literature

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literature

et al. 2009

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“…4). It would be of interest if genes associated with (cancer) stem cell self-renewal, which also have prognostic impact for cancer patients (28), play a role in disseminated tumor cell/circulating tumor cell dormancy. Meng and colleagues (29) showed that uPAR and ERBB2/HER-2 gene status in breast cancer cells from blood and tumor tissue are concordant.…”

Section: Discussionmentioning

confidence: 99%

Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Renal Cell Carcinoma Correlates with Prognosis

Bluemke

Bilkenroth

Meye

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Purpose: The aim of this study was to evaluate the clinical relevance of the presence of disseminated tumor cells in peripheral blood (so-called circulating tumor cells) for renal cell carcinoma patients. Methods: Two hundred thirty-three peripheral blood samples from 154 renal cell carcinoma patients were investigated for the presence of disseminated tumor cells by autoMACS technique and immunocytochemical staining of cytokeratin. The frequency of circulating tumor cells was analyzed statistically for correlation with relevant clinical data. Results: Two kinds of tumor cells were detected: those with expression of cytokeratin 8/18 (CK+) and cells without a detectable cytokeratin expression, which we called large blue-stained cells with a tumorlike morphology. After following the CD45 autoMACS depletion protocol, we identified circulating tumor cells in 96 (41%) of 233 peripheral blood samples, which originated from 81 (53%) of 154 renal cell carcinoma patients.A significant correlation between the detection of circulating tumor cells and positive lymph node status (P < 0.001; χ 2 test) and the presence of synchronous metastases at the time of primary tumor resection (P = 0.014; χ 2 test) was found. In a multivariate Cox's regression hazard model, presence of CK+ circulating tumor cells was significantly correlated with poor overall survival for renal cell carcinoma patients (relative risk, 2.3; P = 0.048). Conclusions:The presence of circulating tumor cells correlated to lymph node status and presence of synchronous metastases in renal cell carcinoma. It is important to evaluate CK+ and blue-stained tumor cells together to determine the role of circulating tumor cells in tumor behavior and disease progression. Detection of CK+ circulating tumor cells in peripheral blood is a significant and independent prognostic factor for renal cell carcinoma. (Cancer Epidemiol Biomarkers Prev 2009;18(8):2190-4)

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“…Overexpression of Piwi,theDrosophilahomologue,resultsinanincreaseboth inthenumberofgermlinestemcellsandtherateoftheir divisions [25].ElevatedexpressionofMili,oneof3mouse Piwi homologues, inhibits apoptosis and stimulates proliferation [26].ExpressionofHiwihasbeenreportedinseminomas, gastric carcinomas, and soft-tissue sarcoma (STS) [25,27,28]. There was an association between altered expression of Hiwi mRNA and a poor prognosis for STS patients [29].…”

Section: Introductionmentioning

confidence: 99%

Expression of PSCA, PIWIL1, and TBX2 in Endometrial Adenocarcinoma

Liu

Xiangyang²,

Zhang³

2010

Onkologie

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Background: Endometrial cancer is the 4th most common gynecological cancer. The expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1), and T-box 2 (TBX2) in endometrial cancer remains to be elucidated. Material and Methods: The expression of PSCA, PIWIL1, and TBX2 was examined using the streptavidin-peroxidase method in 64 endometrial endometrioid adenocarcinoma (EAC) and paired normal endometrium (NE) samples from the Shaanxi Province in China. Results: Positive expression rates of PSCA, PIWIL1, and TBX2 were 75% (48/64), 25% (16/64), and 56% (36/64), respectively in EACs, but 5% (3/64), 6% (4/64), and 2% (1/64), respectively in NEs. The difference was statistically significant (p < 0.05). PSCA was positively correlated with TBX2 (p = 0.003) but not PIWIL1 (p = 0.188). PIWIL1 was positively correlated with TBX2 (p = 0.003). PSCA was positively correlated with age, tumor grade, and lymph node metastasis (p < 0.05). TBX2 had an association with lymph node metastasis (p = 0.014). PIWIL1 was not associated with clinicopathological features (p > 0.05). Conclusions: We report the first analysis of PSCA, PIWIL1, and TBX2 expression in EAC. Our findings suggest that PSCA and TBX2 might be candidate targets for cancer therapy, and have helped us further understand the carcinogenesis of endometrial cancer.

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Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients

Cited by 48 publications

References 19 publications

Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literature

Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literature

Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Renal Cell Carcinoma Correlates with Prognosis

Expression of PSCA, PIWIL1, and TBX2 in Endometrial Adenocarcinoma

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