Expression of PSCA, PIWIL1, and TBX2 in Endometrial Adenocarcinoma

Abstract

Background: Endometrial cancer is the 4th most common gynecological cancer. The expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1), and T-box 2 (TBX2) in endometrial cancer remains to be elucidated. Material and Methods: The expression of PSCA, PIWIL1, and TBX2 was examined using the streptavidin-peroxidase method in 64 endometrial endometrioid adenocarcinoma (EAC) and paired normal endometrium (NE) samples from the Shaanxi Province in China. Results: Positive expression rates of PSCA, PIWIL1, and TBX2 were 75% (48/64), 25% (16/64), and 56% (36/64), respectively in EACs, but 5% (3/64), 6% (4/64), and 2% (1/64), respectively in NEs. The difference was statistically significant (p < 0.05). PSCA was positively correlated with TBX2 (p = 0.003) but not PIWIL1 (p = 0.188). PIWIL1 was positively correlated with TBX2 (p = 0.003). PSCA was positively correlated with age, tumor grade, and lymph node metastasis (p < 0.05). TBX2 had an association with lymph node metastasis (p = 0.014). PIWIL1 was not associated with clinicopathological features (p > 0.05). Conclusions: We report the first analysis of PSCA, PIWIL1, and TBX2 expression in EAC. Our findings suggest that PSCA and TBX2 might be candidate targets for cancer therapy, and have helped us further understand the carcinogenesis of endometrial cancer.

Multiple genetic variants are associated with colorectal cancer risk in the Han Chinese population

“…As suggested by the name, it was first described as an overexpressed marker in prostate cancer (Reiter et al, 1998). Overexpression of PSCA has been thought be limited to several solid cancers in humans, including bladder, endometrium, kidney, pancreas, ovary, central nervous system, and lung cancers (Cao et al, 2005;Elsamman et al, 2006;Kawaguchi et al, 2010;Liu et al, 2010;Geiger et al, 2011). Variations in PSCA expression have been implicated in upper gastrointestinal carcinogenesis, with loss of PSCA expression reported in gastric and esophageal cancers (Bahrenberg et al, 2000;Sakamoto et al, 2008;Saeki et al, 2010;Ono et al, 2012).…”

Emerging roles for PIWI proteins in cancer

“…Besides its use as a single marker, HIWI could increase the detection accuracy (∼80%) in colon adenocarcinoma when used in combination with synuclein-γ (SNCG), phosphatase of regenerating liver-3 (PRL-3), and arrest-defective protein 1 (ARD1) homolog A [35]. In contrast, in endometrioid adenocarcinoma, PIWIL1 was not associated with its clinicopathological features [37].…”

Epigenetic changes as prognostic predictors in endometrial carcinomas

“…These results are in agreement with findings in the literature. In work by Liu et al, 15 positive expression of TBX2 was noted in 56% of endometrioid endometrial carcinoma, but only in 2% of normal endometrial tissue. Expression of the TBX2 gene also had a significant association with lymph node metastasis.…”