Stellenwert und Indikation der SLIT im Vergleich zur SCIT

Abstract

Appropriate specific immunotherapy depends on the correct diagnosis, identification of the clinically relevant allergens and consideration of risks. Standardized high-quality allergen extracts preferably of known major allergen content and with clear-cut proven efficacy in randomized controlled studies should be used for both SCIT and SLIT. The various SCIT and SLIT extracts differ considerably, so an allergen and product specific evaluation is recommended for the respective choice and indication. The German allergy society's comparison of SLIT to SCIT is much less favorable than that of the European society. In the absence of high-quality direct comparisons between the two therapies, a high-quality SCIT should be preferred to SLIT because long-term and preventive effects (development of asthma and new sensitizations) have been demonstrated more satisfactorily for SCIT. If SCIT is out of the question (refusal of injections, systemic side effects of SCIT) a high-quality SLIT may be indicated in adults with rhinoconjunctivitis.

Efficacy of Sublingual Immunotherapy versus Subcutaneous Injection Immunotherapy in Allergic Patients

“…A review of the literature reveals only a few articles that directly address this issue [4–10]. In five of these reports [5–9] SCIT and SLIT are found to be equally effective.…”

“…In five of these reports [5–9] SCIT and SLIT are found to be equally effective. In one report [4] SCIT is found to have better results, and one report [10] finds both equally effective for AR patients but SCIT more effective for asthmatic patients. In our own experience, SLIT and SCIT appear to be of similar efficacy [11] In this report the efficacy of one will be compared against the other.…”