Stellate Ganglion Blockade Provides Relief from Menopausal Hot Flashes: A Case Report Series

Lipov, Eugene; Lipov, Sergei; Stark, Jamie Tyler

doi:10.1089/jwh.2005.14.737

Cited by 37 publications

(24 citation statements)

References 17 publications

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“…The trend seen in this present study, for hot flashes to become more prominent after an initial reduction, has been seen in previous studies done by Lipov et al In their reports, many of the patients received a second block 2–10 weeks after the first [19]. This use of two blocks led to reported benefit lasting for many months [16, 19, 20]. Therefore, it is possible that more than one stellate ganglion block would provide added benefit.…”

Section: Discussionsupporting

confidence: 87%

“…However, there are limited data on the use of stellate ganglion blocks to treat hot flashes, with the only known published manuscripts on this subject, to date, coming from Lipov et al; these investigators have reported a significant decrease in hot flashes in patients who undergo this therapy [16, 19]. In addition, a recent abstract from a different group of investigators reported similar benefits [14].…”

Section: Discussionmentioning

confidence: 99%

“…In 2005, Lipov et al published a case series report involving six women, none of whom had breast cancer, but all of whom had trouble with hot flashes [16]. In a 2008 issue of Lancet Oncology , they reported on a prospective pilot trial ( n =13) looking at stellate ganglion blockade as a means for alleviating hot flashes in patients with a prior history of breast cancer [19].…”

Section: Introductionmentioning

confidence: 99%

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Pilot evaluation of a stellate ganglion block for the treatment of hot flashes

Pachman

Barton

Carns

et al. 2010

Support Care Cancer

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Purpose Hot flashes are a significant problem in breast cancer patients, especially because the most effective therapy, estrogen, is often contraindicated. Based on recent pilot data from a single group supporting the use of a stellate ganglion block for the treatment of hot flashes, the present pilot trial was done to further evaluate the hypothesis that a stellate ganglion block may be a safe and effective therapy for hot flashes. Methods In women with breast cancer who had hot flashes, a stellate ganglion block was performed after 1 week of baseline hot flash data collection. The main efficacy measures were the changes from baseline in hot flash frequency and hot flash score during the 6th week. Results Ten patients were enrolled between 4/23/2009 and 7/10/2009; eight patients were evaluable. After the stellate ganglion block, the mean hot flash frequency and score decreased from baseline values by over 60% during some of the post-treatment weeks. The mean hot flash frequency and score at week 6 decreased from baseline values by 44% and 45%, respectively. There were no significant adverse events clearly attributed to the stellate ganglion blocks. Conclusions The results of this pilot trial support that stellate ganglion blocks may be a helpful therapy for hot flashes. A prospective placebo-controlled clinical trial should be done to more definitively determine this contention.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pilot evaluation of a stellate ganglion block for the treatment of hot flashes

Pachman

Barton

Carns

et al. 2010

Support Care Cancer

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“…Previously, we reported our use of SGB to alleviate severe hot flashes (1). Based on evidence that the stellate ganglion has links with CNS nuclei that modulate body temperature-in particular, those of the insular cortex (2)-we proposed that E.G.…”

Section: To the Editormentioning

confidence: 99%

Cervical Sympathetic Blockade in a Patient with Post-Traumatic Stress Disorder: A Case Report

Lipov¹,

Joshi²,

Lipov³

et al. 2008

Annals of Clinical Psychiatry

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“…Potential treatments include hypnosis, 62 paced breathing/yoga and stellate ganglion block. 63–66 Most of these have shown promise in pilot studies in women, but have not been studied in men with ADT-associated hot flashes. More information and evidence examining use of these methods of therapy will hopefully become available over the next several years.…”

Section: Other Non-pharmacological Treatmentsmentioning

confidence: 99%

Androgen deprivation therapy-associated vasomotor symptoms

Jones¹,

Kohli²,

Loprinzi³

2012

Asian J Androl

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Androgen deprivation therapy (ADT) is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer. While efficacious, ADT is associated with multiple side effects, including decreased libido, erectile dysfunction, diabetes, loss of muscle tone and altered body composition, osteoporosis, lipid changes, memory loss, gynecomastia and hot flashes. The breadth of literature for the treatment of hot flashes is much smaller in men than that in women. While hormonal therapy of hot flashes has been shown to be effective, multiple non-hormonal medications and treatment methods have also been developed. This article reviews current options for the treatment of hot flashes in patients taking ADT.

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Stellate Ganglion Blockade Provides Relief from Menopausal Hot Flashes: A Case Report Series

Abstract: Successful SGB appears to be related to relief of hot flashes. Repeat SGB results in efficacious multiple week relief of severe hot flashes associated with menopause.

Cited by 37 publications

References 17 publications

Pilot evaluation of a stellate ganglion block for the treatment of hot flashes

Pilot evaluation of a stellate ganglion block for the treatment of hot flashes

Cervical Sympathetic Blockade in a Patient with Post-Traumatic Stress Disorder: A Case Report

Androgen deprivation therapy-associated vasomotor symptoms

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