Steatohepatitis in obese individuals

Youssef, Wael; McCullough, Arthur J.

doi:10.1053/bega.2002.0334

Cited by 79 publications

(69 citation statements)

References 119 publications

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“…So we postulated that adiponectin might play an important role in this condition as a protective factor through stimulating fatty acid oxidation, decreasing plasma TG, and improving glucose metabolism by increasing insulin sensitivity. The fact that pro-inflammatory and anti-inflammatory cytokines take part in this condition may be the reason that NAFLD might progress even after weight loss [27]. We also found serum adiponectin levels were positively associated with HDL-C levels, which have been reported to be lower in NALFD [28], but the precise relationship of adiponectin to HDL-C is unclear.…”

Section: Discussionmentioning

confidence: 52%

Serum Adiponectin, Resistin Levels and Non-alcoholic Fatty Liver Disease in Obese Children

et al. 2005

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Abstract. The objective is to investigate the relation between the levels of two serum adipocytokines (adiponectin and resistin) and non-alcoholic fatty liver disease (NAFLD) in obese children. In this study, 113 obese children were enrolled and divided into 3 groups. Obese group 1 was defined as obese children without any liver abnormality. Obese group 2 was defined as obese children just with fatty infiltration of the liver in ultrasonic appearance and obese group 3 was defined as obese children with liver function abnormality. The controls consisted of 37 nonobese children without endocrine, metabolic or kidney disease. The levels of serum adiponectin and resistin were measured by ELISA method. Insulin resistance by homeostasis model (HOMA-IR), area under curve of glucose (AUCG), serum total cholesterol, triglyceride, alanine aminotransferase, uric acid, HDL-cholesterol, LDL-cholesterol and body mass index (BMI) were measured as well. In obese children, NAFLD were found in 63 cases (55.75%). Serum adiponectin levels of obese children were significantly lower than that of controls (3.63 vs 5.79 mg/mL, P<0.001) while serum resistin levels were not different (P = 0.876). Moreover, serum adiponectin levels in obese group 1 were significantly higher than that of group 2 and 3 (4.24 vs 3.37 and 3.12 mg/mL, all P<0.05) and no difference was found between obese group 2 and obese group 3 (P>0.05). Serum resistin levels among the three obese groups were 4.37 ng/mL, 3.72 ng/mL and 4.24 ng/mL without significant difference (P = 0.592). NAFLD, BMI, gender and HDL-cholesterol were independent determinants of serum adiponectin levels in children analyzed by multiple regression analysis, which explained 33% of the variance. Serum adiponectin levels were inversely associated with BMI, gender and NAFLD (all P<0.05) and were positively associated with HDL-cholesterol levels (P = 0.033). These results suggest that adiponectin might be a protective factor in NAFLD occurrence in obese children, and that the measurement of adiponectin should be part of the standard evaluation of the obese child and may help to evaluate the occurrence of NAFLD.

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Section: Discussionmentioning

confidence: 52%

Serum Adiponectin, Resistin Levels and Non-alcoholic Fatty Liver Disease in Obese Children

et al. 2005

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“…Moreover, the prevalence of NAFLD also has been correlated to body mass index. These results are relevant when we considered that obesity is associated to increased visceral adiposity, free fatty acids and hyperinsulinemia, which are involved in the pathogenesis of NAFLD [19,20] .…”

Section: Discussionmentioning

confidence: 89%

Fatty liver disease in severe obese patients: Diagnostic value of abdominal ultrasound

Almeida

Cotrim²,

Barbosa³

et al. 2008

WJG

102

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“…These include Dio1 [encoding deiodinase, a selenoprotein that is downregulated in hypothyroidism, a phenotype that has been reported in patients with NASH ( 8,36 )] and Bzrp [encoding the peripheral-type benzodiazepine receptor that has been associated with hepatic en- Fig. 7.…”

Section: Dysregulated Genes In Isolated Hepatocytes Correlated With Tmentioning

confidence: 99%

A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats

Buqué

Martı́nez

Cano

et al. 2010

Journal of Lipid Research

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Steatohepatitis in obese individuals

Cited by 79 publications

References 119 publications

Serum Adiponectin, Resistin Levels and Non-alcoholic Fatty Liver Disease in Obese Children

Serum Adiponectin, Resistin Levels and Non-alcoholic Fatty Liver Disease in Obese Children

Fatty liver disease in severe obese patients: Diagnostic value of abdominal ultrasound

A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats

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