Steam-Dried Ginseng Berry Fermented with Lactobacillus plantarum Controls the Increase of Blood Glucose and Body Weight in Type 2 Obese Diabetic<i>db</i>/<i>db</i>Mice

Kim, Seung Tae; Kim, Hae Bok; Lee, Kyu Ho; Choi, Young R.; Kim, Hee Jung; Shin, Il Shik; Gyoung, Young Soo; Joo, Seong Soo

doi:10.1021/jf300460g

Cited by 24 publications

(14 citation statements)

References 36 publications

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“…FSGB improved insulin and glucose tolerance levels. It also enhanced immune activities by increasing immune cell population and glucose transporter 1 (GLUT1) mRNA expression in L6 cells was up-regulated, showing that FSGB may increase glucose activity transport to target cells.[68] Lactobacillus acidophilus La5Probiotic yogurt consumption caused a 4.54% decrease in total cholesterol and a 7.45% decrease in LDL-C compared with the control group. Total cholesterol level (HDL-C ratio and LDL-C:HDL-C ratio) significantly decreased in the probiotic group compared to the control[69] Bifidobacterium lactis Bb12 Bifidobacterium animalis subsp.…”

Section: Probiotic Lab and Type-2 Diabetes Treatmentmentioning

confidence: 99%

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Evivie

Gui-cheng

Igene

et al. 2017

Food & Nutrition Research

139

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Several mechanism and non-mechanism-based studies supporting the claim that lactic acid bacteria (LAB) strains confer health benefits and play immune-modulatory roles were examined in this review. Probiotic applications of LAB on global burdens such as obesity and type-2 diabetes were discussed as well as the use of yoghurt and ice cream as important vehicles to convey several beneficial LAB strains. Probiotic and symbiotic dairy products may be used in the nearest future to treat a variety of health disorders. Current studies suggest that lactic acid bacteria possess anti-obesity and anti-diabetic propensities on their hosts and thus can play a crucial role in human health care. Research in the rheological and physicochemical properties of ice cream as well as its applications are also on the increase. These applications face certain hurdles including technological (for less developed countries), consumer acceptability of new functional foods may be influenced by culture, ethics or religion. There is need for more studies on the genetic basis for probiotic properties which will give further understanding regarding novel manipulation skills and applicability in nutrition and health sectors. More studies confirming the direct effects of probiotic LABs in lowering the spread of food-borne and other pathogens are also anticipated.

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Section: Probiotic Lab and Type-2 Diabetes Treatmentmentioning

confidence: 99%

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Evivie

Gui-cheng

Igene

et al. 2017

Food & Nutrition Research

139

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“…One other study was excluded as it reported the same outcomes published previously in line with other new but irrelevant results [38]. Six other studies were excluded as they evaluated the effects of synbiotics [39][40][41][42][43] or prebiotics [44]. Three animal reports that were published in languages other than English were excluded as well [45][46][47].…”

Section: Probiotics and Diabetesmentioning

confidence: 99%

Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Razmpoosh

Javadi

Ejtahed

et al. 2015

Diabetes Metabolism Res

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Probiotics have been suggested to play an important role in the management of diabetes. We conducted a systematic review on the role of probiotics in modulating parameters related to diabetes in animal and human experiments. We searched Pubmed, Scopus and Cochrane central until June 2014, concerning the effects of probiotics on hyperglycemia, hyperinsulinemia and their anti-diabetic efficacies by modulating the activities of proinflammatory and antioxidant factors. Our initial search retrieved 1120 reports. After screening titles and abstracts, 72 full-text articles were reviewed for eligibility. Ultimately, 33 articles met our inclusion criteria consisting of five human and twenty eight animal reports. Lactobacillus strains were, in particular, used in all studies with or without other strains. We found that probiotics have beneficial effects on glycemic controls, as all human studies showed significant reductions in at least one of the primary outcome endpoints which were the levels of fasting plasma glucose, postprandial blood glucose, glycated haemoglobin, insulin, insulin resistance and onset of diabetes; similarly, all the animal reports, except for two, documented significant changes in these parameters. Regarding secondary outcome measures, that is, lipid profiles, pro-inflammatory and anti-oxidant factors, only one human and one animal study failed to show any significant changes in any of these parameters. This systematic review generally demonstrated beneficial effects of the probiotic administration, especially Lactobacillus sub-strains, on the management of diabetes-related blood parameters, although, more evidence, especially from human trials, is needed to confirm these effects and also to conduct a meta-analysis. Copyright © 2015 John Wiley & Sons, Ltd.

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“…Similar results were also observed in db/db mice treated with ginseng extracts. 0.5 g/kg fermented steam-dried ginseng berry (FSGB) [45] significantly decreased body weight and blood glucose in db/db mice during a 35-day treatment; furthermore, the plasma insulin in the FSGB treated group (17.05 ± 0.49 ng/mL) significantly increased almost double compared to the untreated db/db group (8.21 ± 0.60 ng/mL). GLUT1 mRNA expression was up-regulated by FSGB in the L6 skeletal muscle cells.…”

Section: Potential Mechanisms Of the Anti-diabetic Effect Of Ginsengmentioning

confidence: 99%

Review of Ginseng Anti-Diabetic Studies

2019

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Ginseng is one of the most valuable and commonly used Chinese medicines not only in ancient China but also worldwide. Ginsenosides, also known as saponins or triterpenoids, are thought to be responsible for the beneficial effects of ginseng. In this review, we summarize recent publications on anti-diabetic studies of ginseng extracts and ginsenosides in cells, animals, and humans. It seems that the anti-diabetic effect of ginseng is positive for type 2 diabetic patients but has no significant impact on prediabetes or healthy adults. Regulation of insulin secretion, glucose uptake, anti-oxidative stress, and anti-inflammatory pathways may be the mechanisms involved with ginseng’s anti-diabetic effects. Taken together, this summary provides evidence for the anti-diabetes effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their impact on diabetes.

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Steam-Dried Ginseng Berry Fermented with Lactobacillus plantarum Controls the Increase of Blood Glucose and Body Weight in Type 2 Obese Diabeticdb/dbMice

Cited by 24 publications

References 36 publications

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Review of Ginseng Anti-Diabetic Studies

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