Status of the Louisiana accelerator center

Deoli, Naresh; Vera, Armin B. De; Coutee, Kyle L.; Dias, Jay D.; Udeogu, Henry E.; Banerjee, Sanjana; Klerks, Paul L.; Hollerman, William A.; Hasenstein, Karl H.

doi:10.1063/1.5127685

Cited by 7 publications

(5 citation statements)

References 21 publications

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Section: Methodsmentioning

confidence: 99%

“…We utilized the nuclear microscopy setup at the Louisiana Accelerator Center to probe the concentrations of calcium in our samples using particle-induced X-ray emission (PIXE) spectrometry. 24 The samples were placed in a lowpressure environment (≤1 × 10 −6 mbar) on an electrically conductive nonporous carbon tape attached to the sample holder. A focused (10 × 10 μm) 2 MeV proton beam, with a beam current in the range of 10−20 pA, raster scanned the sample region (1 × 1 mm) for about 1 h. A silicon drift detector was placed at 135°in front of the sample to detect the characteristic X-rays excited by energetic protons.…”

Section: Elemental Analysis Of Npsmentioning

confidence: 99%

See 1 more Smart Citation

Injectable Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing

Balaji

Short

Belgodere

et al. 2023

ACS Appl. Mater. Interfaces

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The application of engineered biomaterials for wound healing has been pursued since the beginning of tissue engineering. Here, we attempt to apply functionalized lignin to confer antioxidation to the extracellular microenvironments of wounds and to deliver oxygen from the dissociation of calcium peroxide for enhanced vascularization and healing responses without eliciting inflammatory responses. Elemental analysis showed 17 times higher quantity of calcium in the oxygen-releasing nanoparticles. Lignin composites including the oxygen-generating nanoparticles released around 700 ppm oxygen per day at least for 7 days. By modulating the concentration of the methacrylated gelatin, we were able to maintain the injectability of lignin composite precursors and the stiffness of lignin composites suitable for wound healing after photo-cross-linking. In situ formation of lignin composites with the oxygen-releasing nanoparticles enhanced the rate of tissue granulation, the formation of blood vessels, and the infiltration of α-smooth muscle actin+ fibroblasts into the wounds over 7 days. At 28 days after surgery, the lignin composite with oxygen-generating nanoparticles remodeled the collagen architecture, resembling the basket-weave pattern of unwounded collagen with minimal scar formation. Thus, our study shows the potential of functionalized lignin for wound-healing applications requiring balanced antioxidation and controlled release of oxygen for enhanced tissue granulation, vascularization, and maturation of collagen.

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Section: Methodsmentioning

confidence: 99%

Section: Elemental Analysis Of Npsmentioning

confidence: 99%

Injectable Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing

Balaji

Short

Belgodere

et al. 2023

ACS Appl. Mater. Interfaces

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“…The μ‐PIXE imaging was conducted over areas of 500 μm × 500 μm with 2 MeV protons in the imaging ion microprobe connected to the 1.7 MV Pelletron Accelerator at the Louisiana Accelerator Center. [ 13 ] The proton beam was focused (spot size of 12 μm × 12 μm) and rastered over the sample using a standard Oxford quadrupole lens configuration from Oxford Microbeam Ltd. Characteristic X‐rays were detected using an Amptek Silicon Drift Detector (XR‐100SDD) with active area of 70 mm 2 and 125 eV FWHM resolution at 5–9 keV.…”

Section: Methodsmentioning

confidence: 99%

Heavy Elements Revealed in Jejunum of Simian Immunodeficiency Virus Infected Monkeys by Microparticle Induced X‐Ray Emission

Whitlow

Deoli

Vera

et al. 2020

Physica Status Solidi (a)

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Archived jejunum tissue block specimens from control and simian immunodeficiency virus‐infected rhesus macaques are characterized using particle‐induced X‐ray emission (PIXE) in a MeV ion microprobe with 2 MeV protons. The results show considerable variance in the concentration of some elements (Ti, Mn, and Fe) between viremic and control tissue. Ti, Mn, and Fe are present at levels 50‐fold lower in samples from viremic versus control monkeys, a difference markedly higher than previously reported for infections. Pb and Ti are observed particularly in the crypts of both viremic and control jejunum samples. This is likely to be caused by ingestion of paint fragments picked from the cages used to house the animals.

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“…We utilized the nuclear microscopy setup at the Louisiana Accelerator Center to probe the concentrations of calcium in our samples using particle-induced x-ray emission (PIXE) spectrometry [36]. The samples were placed in a low-pressure environment (≤1×10 −6 mbar) on electrically conductive non-porous carbon tape attached to the sample holder.…”

Section: Elemental Analysis Of Npsmentioning

confidence: 99%

Engineering Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing

Balaji

Short

Farouk

et al. 2022

Preprint

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The application of engineered biomaterials for wound healing has been pursued since the beginning of tissue engineering. Here, we attempt to apply functionalized lignosulfonates to confer antioxidation to tissue microenvironments and to deliver oxygen to accelerate vascularization and healing responses without causing inflammatory responses. The results from fibrosis array shows that thiolated lignosulfonate in methacrylated gelatin can effectively attenuate fibrotic responses of human dermal fibroblasts. Elemental analysis of oxygen releasing nanoparticles shows the positive incorporation of calcium peroxide. Composites including nanoparticles of lignosulfonate and calcium peroxide release around 0.05% oxygen per day at least for 7 days. Stiffness can be precisely modulated to avoid adverse inflammatory responses. Injection of lignin composites with oxygen generation nanoparticles enhanced the formation of blood vessels and promoted infiltration of alpha-smooth muscle actin+ fibroblasts over 7 days. At 30 days after surgery, the lignin composite with oxygen generating nanoparticles remodels the collagen architecture resembling to the reticular pattern of normal collagen and leave minimal scars. Thus, our study shows the potential of functionalized lignosulfonate for wound healing applications requiring balanced antioxidation and controlled release of oxygen.

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Status of the Louisiana accelerator center

Cited by 7 publications

References 21 publications

Injectable Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing

Injectable Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing

Heavy Elements Revealed in Jejunum of Simian Immunodeficiency Virus Infected Monkeys by Microparticle Induced X‐Ray Emission

Engineering Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing

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